Role of P53 Expression in Pterygium in Natives from Hilly Area
Keywords:
P53, PTERYGIUM, HILLY
Abstract
BACKGROUND: Pterygium has been considered an ocular degenerative fibrovascular neoformation for long but abnormal p53 expression reinforces the theory that it is a proliferative condition like a tumor. The present study was aimed to describe the pattern of p53 immunoexpression in pterygium. MATERIAL AND METHODS: We included 50 excised pterygium and 10 normal conjunctival control specimens, processed for histopathology and immunostaining for p53. Cut-off value of p53 expression was taken as 5% epithelial cell positivity. RESULTS: We found higher incidence of pterygium in females and statistically significant positive p53 expression in 38 cases (76%) as compared to control group. No significant association between variations in clinical grade or histological features and abnormal p53 expression in cases and control groups was found. CONCLUSION: p53 overexpression in pterygium suggests that pterygium is a proliferative tissue disorder.References
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19. Ljubojević V, Gajanin R, Amidžić L, Vujković Z. The expression and significance of p53 protein and Ki-67 protein in pterygium. Vojnosanit Pregl 2016;73(1):16–20.
20. Reisman D, McFadden JW, Lu G. Loss of heterozygosity and p53 expression in Pterygium. Cancer Lett 2004;206:77-83.
21. Tsai YY, Chang KC, Lin CL, Lee H, Tsai FJ, Cheng YW. P53 expression in pterygium by immunohistochemical analysis: a series report of 127 cases and review of literature. Cornea 2005:24(5):583-6.
2. Zhang LW, Chen BH, Xi XH, Han QQ, Tang LS. Survivin and p53 expression in primary and recurrent pterygium in Chinese patients. Int J Opthalmol 2011;4(4):388-392.
3. Pelit A, Bal1 N, Akova YA, Demirhan B. P53 expression in pterygium in two climatic regions in Turkey. Indian Journal of Ophthalmology 2009;57(3):203-6.
4. Lu P, Chen X, Kang Y, Ke L, Wei X, Zhang W. Pterygium in Tibetans: a population-based study in China. Clin Experiment Opthalmol 2007;35(9):828-33.
5. Lu J, Wang Z, Lu P, Chen X, Zhang W, Shi K et al. Pterygium in an aged Mongolian population: a population-based study in China. Eye 2009;23:421-7.
6. Zhou W, Zhu Y, Zhang B, Qiu W, Yao Y. The role of ultraviolet radiation in the pathogenesis of pterygia (Review). Molecular Medicine Reports 2016;14(1):3-15.
7. Wu KL, He MG, Xu JJ, Li SZ. The epidemiological characteristic of pterygium in middle aged and the elderly in Doumen County. J Clin Ophthalmol 1999;7(1):17-18.
8. Liu H, Yang J,Zhong L. Prevalence survey on pterygium in two counties of Hainan Province. Chin J Ophthalmol 2001;37:21-3.
9. Cameron M. Geographic distribution of pterygia. Am J Ophthalmol 1964;57:880-3.
10. McCarty CA, Fu CL, Taylor HR. Epidemiology of pterygium in Victoria, Australia. Br J Ophthalmol 2000;84:289-92.
11. Luthra R, Nemesure BB, Wu SY, Xie SH, Leske MC.Barbados Eye Studies Group. Frequency and risk factors for pterygium in the Barbados Eye Study. Arch Ophthalmol 2001;119:1827-32.
12. Dzunic B, Jovanovic P, Zlatanovic G, Veselinovic D, Petrovic A, Stefanovic I. Comparative analysis of histopathological and clinical characteristics of pterygium. Vojnosanit Pregl 2010;67(2):159-65.
13. Nuhoglu F, Turna F, Uyar M, Ozdemir FE, Eltutar K. Is there a relation between histopathologic characteristics of pterygium and recurrence rates? Eur J Ophthalmol 2013;23(3):303-8.
14. Raizada IN, Bhatnagar NK. Pinguecula and pterygium (a histopathological study). Indian J Ophthalmol 1976;24:16-18.
15. Vojnikovic B, Njiric S, Zamolo G, Toth I, Spanjol J, Coklo M. Histopathology of the pterygium in population on Croatian Island Rab. Coll Antropolo 2007;31(1):39-41.
16. Chui J, Coroneo MT, Tat LT, Crouch R, Wakefield D, Di Girolamo N. Ophthalmic pterygium A stem cell disorder with premalignant features. Am J Pathol 2011;178(2):817-27.
17. Sun LL, Warrier S, Beckingsale P. Pterygium and rate of dysplasia in surgical specimens. J Clinic Experiment Ophthalmol 2011;2:166.
18. Weinstein O, Rosenthal G, Zirkin H, Monos T, Lifshitz T, Argov S. Overexpression of p53 tumor suppressor gene in pterygia. Eye 2002;16:619-21.
19. Ljubojević V, Gajanin R, Amidžić L, Vujković Z. The expression and significance of p53 protein and Ki-67 protein in pterygium. Vojnosanit Pregl 2016;73(1):16–20.
20. Reisman D, McFadden JW, Lu G. Loss of heterozygosity and p53 expression in Pterygium. Cancer Lett 2004;206:77-83.
21. Tsai YY, Chang KC, Lin CL, Lee H, Tsai FJ, Cheng YW. P53 expression in pterygium by immunohistochemical analysis: a series report of 127 cases and review of literature. Cornea 2005:24(5):583-6.
Published
2018-10-26
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Section
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