Synovial Sarcoma: a Clinicopathological Study with Emphasis on Rare Sites
Keywords:
Clinico-pathological study, Heart, Kidney, Lung, Synovial Sarcoma.
Abstract
Background: Synovial sarcoma is an infrequently diagnosed soft tissue sarcoma of the younger population with a male preponderance. Although the disease tends to home itself in the extremities particularly around the joints in the vast majority of cases, it can also occur in other surprising locations which warrant careful and meticulous histopathological examination accompanied by a judicious use of the immunohistochemical panel. Methods: Search of the pathology database was done to identify cases of synovial sarcomas in rare sites. Result: seven cases of synovial sarcoma were identified, three of which were at extremely uncommon sites rendering the diagnosis challenging and intriguing. Conclusion: Differential diagnosis of synovial sarcoma should always be kept in mind in a young patient with a mass lesion of short duration, not only at the extremities but also involving other rarer locations like the lungs, heart and kidney.References
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18. Boulmay B, Cooper G, Reith JD, Marsh R. Primary cardiac synovial sarcoma: A case report and brief review of the literature. Sarcoma. 2007;2007:10–3.
19. Dassi V, Das K, Singh BP, Swain SK. Primary synovial sarcoma of kidney: A rare tumor with an atypical presentation. Indian J Urol . 2009;25(2):269–71.
20. Modi G, Madabhavi I, Panchal H, Anand A, Patel A, Parikh S, et al. Primary synovial sarcoma of kidney: a rare differential diagnosis of renomegaly. Case Rep Pathol. 2014;2014(Figure 1):657497.
2. Chandrashekhar A. Sohoni. Synovial sarcoma. Appl Radiol. 2013;42(11):42–4.
3. Arun PS, Saravanan VAS, Aishwarya S. Synovial Sarcoma- A Review. IJCMR. 2017;4(6):1344–6.
4. Ruggiero A. Synovial sarcoma. Orphanet Encycl. 2004 Mar;1–5.
5. Cadman NL, Soule EH, Kelly PJ. Synovial sarcoma. An Analysis of 134 Tumors. Cancer. 1965 May 1;18(5):613–27.
6. Rekhi B, Basak R, Desai SB, Jambhekar NA. Immunohistochemical validation of TLE1, a novel marker for synovial sarcomas. Indian J Med Res. 2012 Nov;136(5):766–75.
7. Terry J, Saito T, Subramanian S, Ruttan C, Antonescu CR, Goldblum JR, et al. TLE1 as a Diagnostic Immunohistochemical Marker for Synovial Sarcoma Emerging From Gene Expression Profiling Studies. Am J Surg Pathol. 2007 Feb;31(2):240–6.
8. Ferrari A, Gronchi A, Casanova M, Meazza C, Gandola L, Collini P, et al. Synovial sarcoma: A retrospective analysis of 271 patients of all ages treated at a single institution. Cancer. 2004;101(3):627–34.
9. Skytting B. Synovial sarcoma. A Scandinavian Sarcoma Group project. Acta Orthop Scand Suppl. 2000;291(August):1–28.
10. Kim CH, Dancer JY, Coffee D, Zhai QJ, Reardon M, Ayala AG, et al. Clinicopathologic study of 24 patients with primary cardiac sarcomas: a 10-year single institution experience. Hum Pathol. 2008;39(6):933–938.
11. Mankin HJ, Hornicek FJ. Diagnosis, classification, and management of soft tissue sarcomas. Cancer Control. 2005;12:5–21.
12. Goldblum JR. An approach to pleomorphic sarcomas: can we subclassify, and does it matter? Mod Pathol. 2014 Jan 1;27:39–46.
13. Thway K, Fisher C. Synovial sarcoma: Defining features and diagnostic evolution. Ann Diagn Pathol. 2014 Dec;18(6):369–80.
14. Ladanyi M. Fusions of the SYT and SSX genes in synovial sarcoma. Oncogene. 2001 Sep 10;20(40):5755–62.
15. Limon J, Mrozek K, Mandahl N, Nedoszytko B, Verhest A, Rys J, et al. Cytogenetics of synovial sarcoma: presentation of ten new cases and review of the literature. Genes Chromosomes Cancer. 1991 Sep;3(5):338–45.
16. Cabuk D, Ustuner B, Akgul AG, Acikgoz O, Yaprak B, Uygun K, et al. Primary synovial sarcoma of lung. Korean J Thorac Cardiovasc Surg. 2014;47(3):306–9.
17. Report C. Primary Synovial Sarcoma of the Lung. Radiol Case Reports . 2006;2(4):679–83.
18. Boulmay B, Cooper G, Reith JD, Marsh R. Primary cardiac synovial sarcoma: A case report and brief review of the literature. Sarcoma. 2007;2007:10–3.
19. Dassi V, Das K, Singh BP, Swain SK. Primary synovial sarcoma of kidney: A rare tumor with an atypical presentation. Indian J Urol . 2009;25(2):269–71.
20. Modi G, Madabhavi I, Panchal H, Anand A, Patel A, Parikh S, et al. Primary synovial sarcoma of kidney: a rare differential diagnosis of renomegaly. Case Rep Pathol. 2014;2014(Figure 1):657497.
Published
2018-11-24
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