Cytomorphological Study of Choroid Plexus Neoplasms and its Correlation with Histopathology
Keywords:
Squash cytology, Histopathology, Choroid plexus neoplasms
Abstract
Background: Choroid plexus neoplasms are uncommon and constitute 0.3 to 0.6% of all brain tumors and 2 to 4% of brain tumors in children below 15 years. Choroid plexus neoplasms pose considerable treatment challenges. CNS Squash cytology (CSC) helps neurosurgeons immensely in the management of choroid plexus neoplasms. The present study aimed at cytomorphological examination of choroid plexus neoplasms on squash smears and to differentiate them from other papillary neoplasms in that location and to correlate with histopathological details. Methods: Intraoperative squash smears of twelve cases of SOLs (Space Occupying Lesions) of ventricles and cerebellopontine angle were included in the present study. Cytological diagnoses were correlated with MRI diagnosis and histopathological evaluation. Result: The study group included 9 (75%) cases of choroid plexus papilloma (CPP), 03 (25%) cases of choroid plexus carcinoma (CPC). Age range was 3 months to 58 years (mean=20.5 yrs) and had equal sex distribution. The tumors were distributed as follows: lateral ventricle (1; 8.33%), fourth ventricle and fourth ventricle with cerebellopontine angle extension (10; 83.34%), and third ventricle (1; 8.33%). Conclusion: Histopathological examination is gold standard in differentiating choroid plexus neoplasms from other papillary neoplasms like Ependymoma and Metastatic adenocarcinoma.References
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2. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, eds. Chapter 5: Choroid plexus tumors. WHO Classification of Tumours of the Central Nervous System. Rev 4th ed. Lyon, France: IARC Press;2006:123-9.
3. Kishore S, Negi G, Meena H, Anuradha K, Pathak PV, Bansal K. Choroid plexus carcinoma in an adult. J Neurosci Rural Pract. 2012;3:71-3.
4. Jeibmann A, Wrede B, Peters O, Wolff JE, Paulus W, Hasselblatt M. Malignant progression in choroid plexus papillomas. J Neurosurg. 2007;107:199-202.
5. Tena-Suck ML, Gomez-Amador JL, Ortiz-Plata A, Salina-Lara C, Rembao-Bojorquez D, Vega-Orozco R. Rhabdoid choroid plexus carcinoma: A rare histological type. Arq Neuropsiquiatr. 2007;65:705–9.
6. Berger C, Thiesse P, Lellouch-Tubiana A, Kalifa C, Pierre-Kahn A, Bouffet E. Choroid plexus carcinomas in childhood: Clinical features and prognostic factors. Neurosurgery. 1998;42:470–5.
7. Wang L, Cornford ME. Coincident choroid plexus carcinoma and adrenocortical carcinoma with elevated p53 expression. A case report of an 18-month-old boy with no family history of cancer. Arch Pathol Lab Med. 2001;126:70–2.
8. Buchino JJ, Mason KG. Choroid plexus papilloma. Report of a case with cytologic differential diagnosis. Acta cytol. 1992;36:95-7.
9. Savage NM, Crosby JH, Reid Nicholson MD. The cytologic findings in choroid plexus carcinoma: Report of a case with differential diagnosis. Diagn cytopathol. 2012;40:1-6.
10. Bucerius J, Meyka S, Michael B, Biersack HJ, Eter N. Papillary thyroid carcinoma with an uncommon spread of hematogenous metastases to the choroid and the skin. J Natl Med Assoc. 2008;100:104–7.
11. Gopal P, Parker JR, Debski R, Parker JC. Choroid plexus carcinoma. Arch Pathol Lab Med. 2008;132:1350–4.
Published
2018-07-26
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