The Clinopathological Profile of Pediatric Patients with Pancytopenia In Vadodara
Keywords:
Pediatric patients, Pancytopenia, Analysis, Clinopathological, Vadodara, Tertiary care hospital
Abstract
Introduction: Pancytopenia is a key clinico-hematological thing comes across in day-to-day meidcal practice. It is a situation dealing with decrease in red blood cells (RBCs), white blood cells (WBCs) and platelets and usually suspected medically with finding of unsolved pallor. Careful check-up of a blood is important if cause for the pancytopenia does not seem from the medical history. If blood examination will not reveal cause then bone marrow aspiration and trephine are of use. Materials and methods: Present study was retrospective in nature and was carried out at Dhiraj General Hospital, Sumandeep Vidyapeeth, Vadodara from January 2014 to December 2015 for period of 2 years. All pediatric patients who came to hospital were became part of present study and undergone necessary investigations like complete blood count (CBC), peripheral smear (PS) examination, bone marrow aspiration and bone marrow trephine biopsy etc. Results: Among 200 pediatric patients, most common age group was ranged from 1 month to 6 years. Megaloblastic anemia (29%) followed by Aplastic anemia (15.0%) found to be reason for pancytopenia whereas 21.5% of pediatric patients showed leukemia as a reason for pancytopenia. Pallor was found to be most common symptoms in about 170 (85%) patients and fever was in 123 (61.5%) patients. Conclusion: Megaloblastic anemia followed by acute leukemia and aplastic anemia are routine causes encountered for pancytopenia in our study.References
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2. Khunger JM, Arulselvi S, Sharma U, Ranga S, Talib VH. Pancytopenia – A clinico haematological study of 200 cases. Indian J Pathol Microbiol., 2002; 45: 375-9.
3. Lewis SM, Bain BJ, Bates I, Dacie JV. Dacie and Lewis Practical Haematology. Philadelphia: Churchill Livingstone/Elsevier; 2006, p. 615.
4. Manzoor F, Karandikar MN, Nimbargi RC. Pancytopenia: A clinicohematological study. Med J Dr. D.Y. Patil Univ., 2014; 7: 27.
5. Kumar R, Kalra SP, Kumar H, Anand AC, Madan M. Pancytopenia-A six year study. J Assoc Physicians India, 2001; 49: 1079–81.
6. Savage DG, Allen RH, Gangaidzo IT, Levy LM, Gwanzura C, Moyo A, et al. Pancytopenia in Zimbabwe. Am J Med Sci., 1999; 317: 22-32.
7. Ameileena C, Vipan C, Anubhava P, Harish C. Clinicoaetiological profile of pancytopenia in pediatric practice. JIACM, 2012; 13(4): 282-5.
8. Goel RG, Bhan MK, Azany S. A study of severe anemia in hospitalized children in Afghanistan. Indian Pediatr., 1981; 18: 643-646.
9. Chandra J, Jain V, Narayan S, Sharma S, Singh V,Kapoor AK, Batra S. Folate & cobalamin deficiency in megaloblastic anemia in children. Indian Pediatr., 2002; 39: 453–57.
10. Gomber S, Kela K, Dhingra N. Clinico-hematologicalprofile of megaloblastic anemia. Indian Pediatr., 1998; 35: 55–58.
11. Sarode R, Garewal G, Marwaha N, Marwaha RK, Varma S, Mohanty D, Das KC. Trop Geogr Med., 1989; 41: 331–36.
12. Mukhbi JM, Makumbi FA, Gwanzura C. Megaloblastic anemia in Zimbabwe: Spectrum of clinical & hematologic manifestations. East Afr Med J, 1992; 69: 83–7.
13. Whitehead MV, Rosenblatt DS, Cooper BA. Megaloblastic Anemia. In: Nathan DG and Orkin SH. (eds), Nathan And Oski’s Hematology of Infancy and Childhood. 5th edition, WB Saunders, Philadelphia,1989; 385–422
14. Memon S, Shaikh S, Nizamani MA. Etiological spectrum of pancytopenia based on bone marrow examination in children. J Coll Physicians Surg Pak., 2008; 18: 163-7.
15. Khair SR, Kaddu S, Visalakshi S, Rao AM. Bleeding manifestations in megaloblastic anemia. Indian Pediatr., 1975; 12: 171-3.
16. Bhatnagar SK, Chandra J, Narayan S, et al. Pancytopenia in children: Etiological profile. J of Trop Pediatr., 2005; 51: 236-9.
17. Jaroonvesama NV. Intravascular coagulation in falciparum malaria. Lancet, 1972; 1: 221–23.
18. World Health Organisation Malaria Action Programme. Severe and complicated malaria. Trans Roy Soc Trop Med Hyg., 1986; 80: 185–88.
19. Perrin LH, Mackey LJ, Miescher PA. The hematology of malaria in man. Semin Hematol., 1982; 19: 70–82.
20. Hemophagocytic syndrome induced by Plasmodium falciparum malaria infection. Int J Hematol., 1996; 64: 263–66.
21. Jaff MS, Mckenna D, McCann SR. Platelet phagocytosis: a probable mechanism of thrombocytopenia in Plasmodium falciparum infection. J Clin Pathol., 1985; 38: 1318–19.
22. Abdalla S, Weatherall DJ, Wickramasinghe SN, Hughes M. The anemia of P. Falciparum malaria. Br J Hematol., 1980; 46: 171–83.
23. Chandra J, Anand V, Patwari AK, Mandal RN, Aneja S, Sharma D. Kala-azar: Experience from non endemic area in India. J Trop Pediatr., 1995; 41: 298-300.
24. Khodke K, Mariah S, Buxi G, Yadav RB, Chaturvedi NK. Bone marrow examination in cases of pancytopenia. J Indian Acad Clin Med., 2001; 2: 55-9.
25. Rathod GB, Alwani M, Patel H, Jain A. Clinico-hematological analysis of Pancytopenia in Pediatric patients of tertiary care hospital. IAIM, 2015; 2(11): 15-19.
Published
2018-12-17
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