Predictor Accuracy of Absolute Neutrophil Count in Early Onset Sepsis
Keywords:
Early Onset Sepsis, Absolute Neutrophil Count
Abstract
Background: The most important causes of mortality in infants are sepsis, prematurity, low birth weight, birth trauma and neonatal asphyxia. Absolute neutrophil count is faster, easier, cheaper and simpler laboratory parameter to be used for prediction of early onset sepsis. This study is aimed to measure the influence of change in the absolute neutrophil count on babies born to mothers having risk factors for infection. Methods: Design of the study was cohort prospective model. Total 123 patients were included in the study after considering appropriate inclusion criteria. The patients were divided into 3groups: ANC (Absolute neutrophil count) < 1800/cmm, ANC 1800-5399/cmm and ANC > 5400/cmm. Results were analysed by GraphpadInstat Demo. Results: New born to mothers having risk factors for sepsis with high ANC (>5400/cmm) and normal ANC (1800-5399/cmm) shows a significant difference with p=0.000 (p<0.05); Odds ratio 9.35, sensitivity 82.8%, specificity 65.9%, positive predictive value79.4% and negative predictive value 70.7%. Conclusion: Incidence of early onset sepsis is 9.35 times higher in new borns born to mothers with risk factors for sepsis having higher ANC (particularly >10000/cmm) than those having ANC level within normal limits.References
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3. Lahariya C, Paul VK. Burden, differentials and causes of child deaths in India. Indian J Pediatr, 2010, 77(11), 1312-1321.
4. Burgner D, Strunk T. Genetic Susceptibility to Neonatal Infection. Department of Neonatal
Paediatrics. Australia. 2006, 19(3): 259-63.
5. Schmutz N, Henry E, Jopling J, Christensen D. Expected ranges for blood neutrophil
concentrations of neonates: The Manroe and Mouzinho charts revisited. J Perinatol.
2008, 28(4): 275-81.
6. Bhandari V, Wang C, Rinder C, Rinder H. Hematologic profile of sepsis in neonates: neutrophil
Cd 64 as a diagnostic marker. Pediatrics. Jan 2008, 121(1):129-34..
7. Bellig L, Ohning, B. Neonatal sepsis. http://emedicine.medscape.com/article/978352-overview. 2014.
8. Anwer K, Mustafa S. Rapid identification of neonatal sepsis. J Pak Med Assoc. 2000 Mar; 50(3):
94-8.
9. Resch B, Gusenleitner W, Muller WD. Procalcitonin and interleukin‐6 in the diagnosis of
Early onset sepsis of the neonate. Acta Paediatrica: Nurturing the child. Jan 2007.
https://doi.org/10.1111/j.1651-2227.2003.tb00534.x
10. Frakking FN, Brouwer N, Eijkelenburg NK, Merkus MP, Kuijpers TW, Offringa M., et al. Low mannose-binding lectin (MBL) levels in neonates with pneumonia and sepsis. British society for immunology, Clinical and Experimental Immunology. 2007; 150: 255-62.
11. Wahab Mohamed WA, Saeed MA. Mannose-binding lectin serum levels in neonatal sepsis
and septic shock. J Matern Fetal Neonatal Med. 2012 Apr, 25(4):411-4.
12. Dzwonek AB, Neth OW, Thiebaut R, Gulczynska E, Chilton M, Hellwig T. The role of mannose-binding lectin in susceptibility to infection in preterm neonates. Pediatric Research, 2008, 63(6):680.
13. Schlapbach LJ, Mattmann M, Thiel S, Boillat C, Otth M, Nelle M., et al. Differential role of the
lectin pathway of complement activation in susceptibility to neonatal sepsis. Clinical Infectious
Diseases, July 2010, 51(2):153-162.
Published
2018-10-26
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