A Study of Hematological Changes in Dengue Patients at A Tertiary Care Hospital, Bhavnagar, Gujarat
Keywords:
Dengue fever, Thrombocytopenia, Leucopenia
Abstract
Background: Dengue is one of the most common arthropod-borne viral (arboviral) illness in humans. It is transmitted by mosquitoes of the genes aedes-principally aedes aegypti. Present study focuses on the haematological changes in serologically proven dengue positive patients in tertiary care hospital. Methods: Retrospective observational study was conducted amongst NS1antigen/IgM dengue positive dengue patients in a tertiary care hospital for a period of 6 months.Complete hemogram of one hundred patients was studied and analysed. Result: Out of the 100 patients studied, 65% patients were in 12-30 years age groups and 75% were males. Leucopoenia was noticed in 36% of cases. Thrombocytopenia at presentation was seen in 94 % of cases. Raised liver serum transaminases, predominantly SGOT were found in 16 out of 20 patients. Conclusion: Fever associated with thrombocytopenia, leucopoenia and elevated liver transaminases should prompt a clinician on the possibility of dengue infection. Platelet transfusions have a little role in management of dengue patients.References
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15. Ali N, Usman M, Syed N, Khurshid M. Haemorrhagic manifestations and utility of haematological
parameters in dengue fever tertiary care centre experience at Karachi. Scand J Infect Dis. 2007;
39:1025-8.
16. Gawoski JM, Ooi WW. Dengue fever mimicking plasma cell leukemia. Arch Pathol Lab Med. 2003;
127(8):1026-7.
17. Roberto da Justa Pires Neto, Saulo Lacerda Borges de Sá et al. Dengue infection in children and
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Observational study in Chennai, south India. Indian J Med Res. 2010;132(6):738–740.
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investigations and early diagnosis of dengue fever in adults: a descriptive study in Sri Lanka.
Southeast Asian J Trop Med Public Health. 2005;36(3):686-92.
24. Babaliche P, Doshi D. Catching Dengue Early: Clinical Features and Laboratory Markers of Dengue
Virus Infection. J Assoc Physicians India. 2015;63(5):38-41.
2. Jain A, Shah AN, Patel P et al. A clinico-hematological profile of dengue outbreak among
healthcare professionals in a tertiary care hospital of Ahmedabad with analysis on economic
impact. Nat J Comm Med. 2013;4:286-90.
3. Gubler DJ. The global emergence/ resurgence of arboviral disease as public health problem. Arch
Med Res. 2002;33:330-42.
4. Deshwal R, Qureshi MI, Singh R. Clinical and Laboratory Profile of Dengue Fever. japi. 2015;63:30-
32.
5. Shah GS, Islam S, Das BK. World health Organization. Dengue and dengue haemorrhagic fever.
kumj. (2006);4:40-43.
6.Moideen JCA, Sathikali AS, Syed S. Clinical and hematological parameter in adult dengue patients.
mimj. 2017;4(3):306-309.
7. Vulavala S, Reddy Y, Kamarthy P. Study of clinical and laboratory profile of dengue fever patients.
Ejpm. 2016;3(11):613-616.
8. Ministry of Health & Family Welfare: Guidelines for Clinical Management of Dengue Fever, Dengue
Hemorrhagic Fever and Dengue Shock Syndrome. New Delhi, India: Govt of India; 2008:2-14.
9. World Health Organization (WHO) and the Special Programme for Research and Training in
Tropical Diseases(TDR). Dengue: guidelines for diagnosis, treatment,prevention and control– New
Edition. Geneva, Switzerland. World Health Organisation. 2009:10-14.
10. Chavan SA , Padhiyar R, Kamtalwar S, Darole P. Study of clinical and laboratory predictors of in
hospital outcome in dengue fever in Mumbai city. IJRTSAT. 2016;19(2)304-308.
11. Kumar R, Shanker S, Ranjan R. A clinical and biochemical study of dengue fever in Kosi region of
Bihar, India. IJAM. 2017;4(4):964-967.
12. Narayanan M, Aravind MA, Thilothammal N, Prema R, Sargunam CS, Ramamurty N. Dengue Fever
Epidemic in Chennai - A Study of Clinical Profile and Outcome. Indian Pediatr. 2002;39:1027-1033.
13. Kalayanarooj S, Vaughn DW, Nimmannitya S et al. Early Clinical and Laboratory Indicators of
Acute Dengue Illness. IJID. 1997;176:313–21
14. Choudhary S, B.R Shivkumar , Adisesha S, Y.A. Manjunatha , M.M. Priyadarshini. Haematological
changes in dengue fever. njbms. 2003;III(4 ):289-293.
15. Ali N, Usman M, Syed N, Khurshid M. Haemorrhagic manifestations and utility of haematological
parameters in dengue fever tertiary care centre experience at Karachi. Scand J Infect Dis. 2007;
39:1025-8.
16. Gawoski JM, Ooi WW. Dengue fever mimicking plasma cell leukemia. Arch Pathol Lab Med. 2003;
127(8):1026-7.
17. Roberto da Justa Pires Neto, Saulo Lacerda Borges de Sá et al. Dengue infection in children and
adolescents in northeast Brazil. Rev. Soc. Bras. Med. Trop. 2013;46(6):765-768.
18.Lei HY, Yeh TM, Liu HS, Lin YS, Chen SH, Liu CC. Immuno pathogenesis of dengue virus infection. J
Biomed Sci. 2001;8:377-388.
19.Schexneider KI, Reddy EA. Thrombocytopenia in dengue fever. Curr Hematol Rep. 2005; 4:145-
148.
20.Bhaskar M, Moorthy S, Kumar NS, Arthur P. Dengue haemorrhagic fever among adults – An
Observational study in Chennai, south India. Indian J Med Res. 2010;132(6):738–740.
21.Seneviratne SL, Malavige GN, Silva HJ. Pathogenesis of liver involvement during dengue viral
infections. Trans R Soc Trop Med Hyg. 2006;100:608-614.
22.Silva EM, Conde JN, Allonso D, Nogueira ML, Mohana-Borges R. Mapping the Interactions of
Dengue Virus NS1 Protein with Human Liver Proteins Using a Yeast Two-Hybrid System:
Identification of C1q as an Interacting Partner. PLoS One. 2013;8:e57514.
23.Kularatne SA, Gawarammana IB, Kumarasiri PR. Epidemiology, clinical features, laboratory
investigations and early diagnosis of dengue fever in adults: a descriptive study in Sri Lanka.
Southeast Asian J Trop Med Public Health. 2005;36(3):686-92.
24. Babaliche P, Doshi D. Catching Dengue Early: Clinical Features and Laboratory Markers of Dengue
Virus Infection. J Assoc Physicians India. 2015;63(5):38-41.
Published
2018-12-17
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