Icthyosis Uteri with in Situ Carcinoma

Report of 2 Cases

  • Almas Iqbal Pathan Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune India
  • Jyoti Kiran Kudrimoti Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune India
  • Shaila Chandrakant Puranik Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune India
DOI: https://doi.org/10.21276/apalm.2166
Keywords: Dysplasia, CIN, pyometra, Hysterectomy

Abstract

Icthyosis uteri is a rare condition in which entire surface of the endometrium is replaced by stratified squamous epithelium. Two cases of Icthyosis uteri are reported for their rarity. The first case was of a 70 year old female with a history of lower abdominal pain and white PV (per vaginal) discharge since 3 months. The second case was of a 70 year old female with history of PV (per vaginal) spotting and breathlessness since 1 year. Gross examination of uterine cavity showed rough and irregular endometrial surface in the first case while in second case endometrium was atrophic. Microscopy of endometrium in both cases revealed total replacement of endometrial glands by stratified squamous epithelium with changes of in situ carcinoma or severe dysplasia. Cervix also showed severe dysplasia or CIN (cervical intra epithelial neoplasia) III in both the cases.

Author Biographies

Almas Iqbal Pathan, Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune India
Department of  Pathology
Jyoti Kiran Kudrimoti, Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune India
Department of Pathology
Shaila Chandrakant Puranik, Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune India
Department of Pathology

References

1. Patton WT, Squares GV. Ichthyosis uteri: a case report.Am J Obstet Gynecol. 1962;84:858– 860.
2. Chhanda B et al, Ichthyosis Uteri-A Case Report and Review of the Literature. Arch Pathol Lab Med. 2005;129:e124–e125
3. O Fadare. Dysplastic Ichthyosis Uteri-like changes of the entire endometrium associated with a squamous cell carcinoma of the uterine cervix. Diagn Pathol. 2006; 1: 8.
4. Kanchan M et al, Does "ichthyosis uteri" have malignant potential? : A case report of squamous cell carcinoma of endometrium associated with extensive ichthyosis uteri .Diagnostic Pathology.2008:3(4)
5. Nishu B et al, Ichthyosis Uteri Associated with Endometrial Adenocarcinoma: A Case Report,Journal of Clinical and Diagnostic Research. 2017 :11(6): ED24-ED25
6. Permeet K B et al, Primary endometrial squamous cell carcinoma with extensive squamous metaplasia and dysplasia, Indian Journal of Pathology and Microbiology. 2008 : 51( 2) : 267-268
7. Sathe P A et al, Ichthyosis Uteri, Journal of Postgraduate Gynecology & Obstetrics.2014:08
8. Rayapa R T et al, Dysplastic ichtyosis uteri of endometrium associated with squamous cell carcinoma insitu of cervix –does it have malignant potential, IOSR Journal of dental and medical sciences. 2014:13(6):64-67
9. Shailja P W, Kavita M. Ichthyosis uteri: An incidental finding with review of literature. Muller J Med Sci Res : 2014 : 5 (1) : 89-91
Published
2018-11-29
Issue
Vol 5 No 11 (2018)
Section
Case Report

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).