Chronic Disseminated Histoplasmosis in a Young Immunocompetant Patient of Hypobetalipoproteinemia: A rare Presentation

  • Rakesh Kumar Gupta G. B. Pant Institute of Post Graduate Medical Education and Research
  • Vineeta Vijay Batra G. B. Pant Institute of Post Graduate Medical Education and Research, New Delhi
  • Puja Sakhuja Dept of Pathology, G. B. Pant Institute of Post Graduate Medical Education and Research, New Delhi
  • Amol Dahale Department of Gastroenterology, G. B. Pant Institute of Post Graduate Medical Education and Research, New Delhi
  • Amarender Singh Puri Department of Gastroenterology, G. B. Pant Institute of Post Graduate Medical Education and Research, New Delhi
Keywords: Histoplasmosis, Immunocompetant, Hypobetalipoproteinemia,

Abstract

Disseminated histoplasmosis is commonly found in immunocompromised patients in association with acquired immunodeficiency syndrome in endemic regions but is rare in other parts of the world. We herein describe a case of subacute disseminated histoplasmosis in a young 20-year-old lady presenting with the chief complaints of pyrexia of unknown origin, loose stools and generalized body swelling with a previous diagnosis of hypobetalipoproteinemia. Supraclavicular lymph node, bone marrow aspiration and colonic biopsy revealed numerous yeast forms of fungus histoplasma. This case illustrates that DH should be ruled out in immunocompetent non-endemic patients presenting with chronic fever even in the absence of respiratory symptoms. 

Author Biographies

Rakesh Kumar Gupta, G. B. Pant Institute of Post Graduate Medical Education and Research
Senior resident Department of Pathology
Vineeta Vijay Batra, G. B. Pant Institute of Post Graduate Medical Education and Research, New Delhi
Professor, Dept of Pathology, Academic Block, G. B. Pant Institute of Post Graduate Medical Education and Research, New Delhi
Puja Sakhuja, Dept of Pathology, G. B. Pant Institute of Post Graduate Medical Education and Research, New Delhi
Professor, Dept of Pathology
Amol Dahale, Department of Gastroenterology, G. B. Pant Institute of Post Graduate Medical Education and Research, New Delhi
Senior resident, Department of Gastroenterology
Amarender Singh Puri, Department of Gastroenterology, G. B. Pant Institute of Post Graduate Medical Education and Research, New Delhi
Professor, Department of Gastroenterology

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Published
2015-05-10
Section
Case Report