Study of Interleukin-6 as an Indicator Biomarker in Perinatal Asphyxia

  • Tajuddin Mohd Delhi State Cancer Institute, Delhi, India
  • Iqbal R Kaur UCMS & GTB Hospital, Delhi, India
  • Bineeta Kashyap UCMS & GTB Hospital, Delhi, India
  • MMA Faridi UCMS & GTB Hospital, Delhi, India
  • N P Singh UCMS & GTB Hospital, Delhi, India
Keywords: IL-6, neonates, perinatal, asphyxia, 48 hours


Background: Birth asphyxia, though not always a recognizable cause, is a well documented contributor to perinatal and neonatal mortality. Four million babies are born asphyxiated annually resulting into 20% of all neonatal deaths. Perinatal asphyxia is the fifth largest cause of under-5 deaths Methods: Serum IL-6 levels were measured by ELISA in sera of thirty newborn babies ≥31 weeks of gestation with Apgar score <8 at 1 minute after birth with perinatal asphyxia (Study group) and 30 age and sex matched healthy controls (Control group), at birth (within 6 hours) and 48 hours after delivery. Result: The mean levels of IL-6 in the study and control groups were 158.09±63.76 pg/ml and 41.57±71.23 pg/ml at birth and 187.96±30.31 pg/ml and 24.54±58.74 pg/ml at 48 hours respectively. Rise in levels of IL-6 in study group when compared with the control was statistically significant both at birth and at 48 hours. The median IL-6 levels in the study group and control group were 196.40 pg/ml and 4.17 pg/ml respectively at birth. The median IL-6 levels in the study group at birth were 47 fold higher than levels of control group. Median IL-6 levels both at birth and at 48 hours were statistically not significant among the mild, moderate and severely asphyxiated neonates. Amongst 30 healthy neonates, IL-6 levels were statistically not significant both at birth and at 48 hours. Conclusion: IL-6 levels were significantly raised at birth and after 48 hours in asphyxiated neonates compared to gestational age and sex matched healthy neonates.

Author Biographies

Tajuddin Mohd, Delhi State Cancer Institute, Delhi, India
Department of Microbiology
Iqbal R Kaur, UCMS & GTB Hospital, Delhi, India
Department of Microbiology
Bineeta Kashyap, UCMS & GTB Hospital, Delhi, India
Department of Microbiology
MMA Faridi, UCMS & GTB Hospital, Delhi, India
Department of Pediatrics
N P Singh, UCMS & GTB Hospital, Delhi, India
Department of Microbiology


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Original Article