A Comparative Analysis of Relationship Between Hypothyroidism and Platelet Parameters Including Platelet Indices, Platelet Distribution Width, Plateletcrit and P-LCR
Keywords:
Platelet parameters, Hypothyroidism, Mean platelet volume, Platelet distribution width, Cardiovascular complications
Abstract
Background: Patients with hypothyroidism are at increased risk of haemorrhage and there is a tendency to develop thromboembolic complications. MPV which is an indicator of platelet activity can act as an individual independent risk factor for cardiovascular complications. Identification of changes in these parameters using automated cell counters are proved to be cost effective and routinely done during clinical practice. This study is aimed to evaluate the influence of hypothyroidism on platelet indices including platelet count, MPV, PDW, plateletcrit and P-LCR and to compare the results with age matched normal euthyroid subjects. Methods: Prospective cross-sectional study was conducted for a period of 8 months between 60 hypothyroid subjects and 60 normal adults as a control group. Demographic details were compared between the groups. Fasting blood sample was collected to determine thyroid profile. Complete blood count (CBC) including platelet indices and peripheral smear examination were done. Results: Male: female ratio was 1:8.6 %, The median age was 43 with a range of 34–52 years. Among the baseline data actual difference was not statistically significant. On comparing with control group T3 and T4 values showed statistically significant decrease (p<0.00 and 0.006), and TSH value shows statistically significant increase in (p<0.00) values. Statistically significant increase was noted in MPV (p<0.03, t value 2.165) and platelet distribution width (p<0.02, t value 2.334). Significant p values were not found in platelet count (p<0.22, t value 1.238) P-LCR (p<0.48, t value 0.697) and PCT p <0.24, t value 1.188) among the groups. Conclusion: Our results suggest that MPV and PDW are the reliable markers among the platelet parameters, can be used as a CVD risk evaluation parameters in hypothyroid patients.References
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14. Dincel O, Bayraktar C. Evaluation of platelet indices as a useful marker in papillary thyroid carcinoma. Bratisl Lek Listy. 2017;118(3):153-5.
15. Oncel M, Kiyici A, Oncel M, Sunam GS, Sahin E, Adam B. Evaluation of Platelet Indices in Lung Cancer Patients. Asian Pac J Cancer Prev. 2015;16(17):7599-602.
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2. Shah S.N., Joshi S.R. Thyroid as an endocrine organ. JAPI 2000; 48: 7-8.
3. Monika H, Alois G, Arnulf F et.al. Altered Platelet Plug Formation in Hyperthyroidism and Hypothyroidism. The Journal of Clinical Endocrinology & Metabolism 2007; 92: 3006–3012
4. Singh V, Catlett, Joseph P. Hematologic Manifestations of Thyroid Disease. The Endocrinologist. 1998; 8: 2
5. Francesco S, Maria L G, Gianluca N, et al. Hypothyroidism and platelet parameters evaluation: a preliminary study. Endocrine Abstracts 2015; 37: 965
6. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: A systematic review and meta-analysis. J ThrombHaemost. 2010; 8:148–56.
7. Dorgalale A, Mahmoodi M, Varmaghani B. Effect of Thyroid Dysfunctions on Blood Cell Count and Red Blood Cell Indices Iran J Ped Hematol Oncol. 2013; 3(2): 73–77.
8. Ren et al. No associations exist between mean platelet volume or platelet distribution width and thyroid function in Chinese. Medicine 2016; 95:40
9. Iddha M.A, Macharia B.N, Ng’wena A.G. Thryroid Hormones and Hematological Indices Levels in Thyroid Disorders Patients at Moi Teaching and Referral Hospital. ISRN Endocrinology. 2013;1-10
10. Sahbaz A, Cicekler H, Aynioglu O, Isik H, Ozmen U. Comparison of the predictive value of plateletcrit with various other blood parameters in gestational diabetes development. J ObstetGynaecol. 2016; 36(5):589-93.
11. Jung DH, Lee HR, Lee YJ, et al. The association between coronary artery calcification and mean platelet volume in the general population. Platelets 2011; 22: 567
12.Slavka G, Perkmann T, Haslacher H, et al. Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease. Arterioscler Thromb Vasc Biol. 2011;31: 1215–8.
13. Erikci AA, Karagoz B, Ozturk A et al. The effect of subclinical hypothyroidism on platelet parameters. Hematology 2009;14(2):115-7.
14. Dincel O, Bayraktar C. Evaluation of platelet indices as a useful marker in papillary thyroid carcinoma. Bratisl Lek Listy. 2017;118(3):153-5.
15. Oncel M, Kiyici A, Oncel M, Sunam GS, Sahin E, Adam B. Evaluation of Platelet Indices in Lung Cancer Patients. Asian Pac J Cancer Prev. 2015;16(17):7599-602.
16. Erdal U, Seyit M C, Efe S et al. Evaluation of Hemocytometer Parameters as Potential Biomarkers in Benign Multinodular Goiter and Papillary Thyroid Carcinoma. Iranian Red Crescent Medical Journal. 2017; 19: 12
17. Yeom E, Byeon H, Lee SJ. Effect of diabetic duration on hemorheological properties and platelet aggregation in streptozotocin-induced diabetic rats. Sci Rep. 2016; 6:21913.
Published
2018-12-27
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