Gliosarcoma with Chondrosarcomatous Differentiation
A Case Report
Keywords:
Chondrosarcoma, Glioblastoma, Gliosarcoma, PTEN, TERT
Abstract
Gliosarcoma (GS) is a variant of IDH wild type of glioblastoma (WHO grade IV). It is characterized by biphasic tissue pattern showing glial and mesenchymal components. The glial component is usually similar to glioblastoma and the sarcomatous component is usually spindle cell type. Rarely the sarcomatous component can show additional lines of mesenchymal differentiation like cartilage, bone, smooth muscle, skeletal muscles etc. These tumours are more firm and discrete because of the high content of reticulin and collagen in the sarcomatous component. Originally these tumours were thought to arise from sarcomatous transformation of proliferating blood vessels or dedifferentiation of an advanced glioma. The recent studies show that both glial and sarcomatous component show identical mutations in p53, PTEN and TERT genes and suggest a monoclonal origin from a common stem cell. There is no significant difference in prognosis between glioblastoma and gliosarcoma. Here we report a case of gliosarcoma with chondrosarcomatous differentiation in a 52 year old gentleman. The case is presented here for its rarity.References
1. Burger PC, Giangaspero F, Ohgaki H, Biernat W. In: Louis DN, Ohgaki H, Wiestler DO, Cavenee WK editors. WHO Classification of Tumours of the Central Nervous System, Revised 4th edition. Lyon: IARC Press; 2016. p. 48–9.
2. Barut F, Kandemir NO, Ozdamar SO, Gul S, Bektas S, Gun BD et al. Gliosarcoma with chondroblastic osteosarcomatous differentation: report of two case with clinicopathologic and immunohistochemical features. Turk Neurosurg 2009; 19:417-22.
3. Ravisankar S, Chander RV, Devadoss PK. Pediatric gliosarcoma with fibrosarcomatous differentiation: Report of a rare case. Indian J Pathol Microbiol 2012;55:521-4.
4. Barresi V, Cerasoli S, Morigi F, Cremonini AM, Volpini M, Tuccari G. Gliosarcoma with features of osteoblastic osteosarcoma: a review. Arch Pathol Lab Med 2006;130:1208–11.
5. Feigin IH, Gross SW: Sarcoma arising in glioblastoma of the brain. Am J Pathol 31:633–653,1955.
6. Yao K, Qi, X.-L, Mei, X, Jiang T. Gliosarcoma with primitive neuroectodermal, osseous, cartilage and adipocyte differentiation: a case report. Int J Clin Exp Pathol 2015; 8; 2079–84.
7. Alatakis S, Stuckey S, Siu K, McLean C. Gliosarcoma with osteosarcomatous differentiation: a review of radiological and pathological features. J Clin Neurosci 2004;11:650–6.
8. Machuca TN, Prevedello DM, Pope LZ, Haratz SS, Araujo JC, Torres LF. Gliosarcoma: report of four cases with immunohistochemical findings. Arq Neuropsiquiatr 2004;62:608-12.
9. Brat DJ, Perry A. Astrocytic and Oligodendroglial Tumors. In: Practical Surgical Neuropathology: A Diagnostic approach. Philadelphia: Churchil Livingstone Elsevier;2010. p. 70.
10. Winkler PA, Buttner A, Tomezzoli A, Weis S. Histologically repeatedly confirmed gliosarcoma with long survival: review of the literature and report of a case. Acta Neurochir 2000;142:91- 5.
2. Barut F, Kandemir NO, Ozdamar SO, Gul S, Bektas S, Gun BD et al. Gliosarcoma with chondroblastic osteosarcomatous differentation: report of two case with clinicopathologic and immunohistochemical features. Turk Neurosurg 2009; 19:417-22.
3. Ravisankar S, Chander RV, Devadoss PK. Pediatric gliosarcoma with fibrosarcomatous differentiation: Report of a rare case. Indian J Pathol Microbiol 2012;55:521-4.
4. Barresi V, Cerasoli S, Morigi F, Cremonini AM, Volpini M, Tuccari G. Gliosarcoma with features of osteoblastic osteosarcoma: a review. Arch Pathol Lab Med 2006;130:1208–11.
5. Feigin IH, Gross SW: Sarcoma arising in glioblastoma of the brain. Am J Pathol 31:633–653,1955.
6. Yao K, Qi, X.-L, Mei, X, Jiang T. Gliosarcoma with primitive neuroectodermal, osseous, cartilage and adipocyte differentiation: a case report. Int J Clin Exp Pathol 2015; 8; 2079–84.
7. Alatakis S, Stuckey S, Siu K, McLean C. Gliosarcoma with osteosarcomatous differentiation: a review of radiological and pathological features. J Clin Neurosci 2004;11:650–6.
8. Machuca TN, Prevedello DM, Pope LZ, Haratz SS, Araujo JC, Torres LF. Gliosarcoma: report of four cases with immunohistochemical findings. Arq Neuropsiquiatr 2004;62:608-12.
9. Brat DJ, Perry A. Astrocytic and Oligodendroglial Tumors. In: Practical Surgical Neuropathology: A Diagnostic approach. Philadelphia: Churchil Livingstone Elsevier;2010. p. 70.
10. Winkler PA, Buttner A, Tomezzoli A, Weis S. Histologically repeatedly confirmed gliosarcoma with long survival: review of the literature and report of a case. Acta Neurochir 2000;142:91- 5.
Published
2019-02-15
Issue
Section
Case Report
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
