Clinico-Pathological Analysis of Thymic Epithelial Tumours
An Institutional Study
Keywords:
Anterior mediastinum, Thymic epithelial tumours, Myasthenia gravis, Masaoka staging
Abstract
Background: Thymic epithelial tumours are anterior mediastinal neoplasms and they exhibit a spectrum of histomorphological features. Methods: In this study we analysed the clinico-pathological spectrum of thymic epithelial tumors at our institution. It is a retrospective and descriptive study done at our Department of Pathology, Amala Institute of Medical Sciences, Thrissur, Kerala over a period of ten years from August 2008 to August 2018. Histological sections of each case were meticulously analysed. Immunohistochemistry was done if needed. Result: In this study 17 cases of thymic epithelial tumors were analysed. A male preponderance of 58.8% was observed. Age ranged from 24 to 73 years with a mean age range of 54.4 years. Most common histological subtype of thymoma was Type B and Type AB. 4 cases were associated with myasthenia gravis. Masaoka Stage I was commonly observed. Conclusion: Thymic epithelial tumors are a unique group of anterior mediastinal neoplasms which also pose a diagnostic challenge. This study highlights the significance of clinico-pathological correlation and staging of thymic neoplasms.References
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large Indian experience. Indian J Cancer 2014 Apr-Jun;51(2):109-12.
13. Weis C-A, Yao X, Deng Y, et al. The Impact of Thymoma Histotype on Prognosis in a
Worldwide Database. Journal of Thoracic Oncology. 2015;10(2):367-372.
14 Nakagawa K1, Asamura H, Matsuno Y, Suzuki K, Kondo H, Maeshima A, Miyaoka
E, Tsuchiya R. Thymoma: a clinicopathologic study based on the new World Health
Organization classification. J ThoracCardiovascSurg 2003 Oct;126(4):1134-40.
15. Rajan A, Wakelee H, Giaccone G. Novel Treatments for Thymoma and Thymic
Carcinoma. Frontiers in Oncology. 2015;5:267.
2. Harris K, Elsayegh D, Azab B, Alkaied H, Chalhoub M. Thymoma calcification: Is it clinically meaningful? World Journal of Surgical Oncology. 2011;9:95.
3. Zhang Z, Cui Y, Jia R, Xue L, Liang H. Myasthenia gravis in patients with thymoma affects survival rate following extended thymectomy. Oncology Letters. 2016;11(6):4177-4182.
4. Wilkins KB, Sheikh E, Green R, et al. Clinical and Pathologic Predictors of Survival in Patients WithThymoma. Annals of Surgery. 1999;230(4):562.
5. Li X, Wang M, Sun D. Sclerosingthymoma: A rare case report and brief review of literature. NA., ed. Medicine. 2018;97(16):e0520.
6. Sperling B, Marschall J, Kennedy R, Pahwa P, Chibbar R. Thymoma: a review of the clinical and pathological findings in 65 cases. Canadian Journal of Surgery. 2003;46(1):37-42.
7. Shamsuddin F, Khadilkar UN, Saha D, SreedharanS, A clinicopathologicstudy of
mediastinal lesions with special emphasis on thymoma. Int J Res Med Sci
2015;3 (8) :1902-10.
8. Sperling B, Marschall J, Kennedy R, Pahwa P, Chibbar R. Thymoma: a review of the
clinical and pathological findings I n 65 cases. Canadian Journal of Surgery. 2003;46(1):37-42.
9. Lewis JE, Wick MR, Scheithauer BW, Bernatz PE, Taylor WF.Thymoma: a
clinicopathologic review. Cancer. 1987;60(11):2727-43.
10.Masaoka A, Monden Y, Nakahara K, Tanioka T. Follow-up study of thymomas with
special reference to their clinical stages. Cancer. 1981;48(11):2485-92.
11.Chen G, Marx A, Chen WH, et al. New WHO classification predicts prognosis of thymic epithelial tumors: A clinicopathologic study of 200 thymoma cases from China. Cancer .2002;95(2):420-9.
12. Rathod S , Munshi A , Paul S , Ganesh P , Prabhash K , Agarwal JP . Thymoma : First
large Indian experience. Indian J Cancer 2014 Apr-Jun;51(2):109-12.
13. Weis C-A, Yao X, Deng Y, et al. The Impact of Thymoma Histotype on Prognosis in a
Worldwide Database. Journal of Thoracic Oncology. 2015;10(2):367-372.
14 Nakagawa K1, Asamura H, Matsuno Y, Suzuki K, Kondo H, Maeshima A, Miyaoka
E, Tsuchiya R. Thymoma: a clinicopathologic study based on the new World Health
Organization classification. J ThoracCardiovascSurg 2003 Oct;126(4):1134-40.
15. Rajan A, Wakelee H, Giaccone G. Novel Treatments for Thymoma and Thymic
Carcinoma. Frontiers in Oncology. 2015;5:267.
Published
2018-11-29
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Section
Original Article
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