A Study of Clinico-Histopathological Correlation of Leprosy in A Tertiary Care Hospital, KIMS, Hubballi, Karnataka
Keywords:
Histopathology, leprosy, granuloma, skin biopsy
Abstract
Background: Leprosy is a chronic infectious disease affecting mainly cutaneous and peripheral nervous system. Histopathology provides confirmatory information for suspected cases which can be missed in clinical practice or epidemiological studies and helps in exact typing. This study was conducted to know the correlation between clinical and histopathological diagnosis of Leprosy. Methods: This was both a retrospective study and prospective study, undertaken in the Department of Pathology, Karnataka Institute of Medical Sciences, Hubballi, over a period of 42 months from January 2013 to June 2016. Punch biopsies were taken from clinically diagnosed, clinically suspected cases of leprosy, relapse cases and lepra reactions and histopathological examinations were carried upon. Results: A total of 280 patients were studied. Of them 193 patients (68.92%) were males and rest 87 (31.08%) patients were females. The maximum incidence was seen in the age group of 21-40yrs with 127cases (45.36%). Maximum number of patient both clinically and histologically belonged to Borderline tuberculoid leprosy. Clinical and histopathological correlation was seen in 61 cases (33.70%). Conclusion: Correlation of clinical and histopathological features along with bacteriological index is more useful for accurate typing of leprosy than considering single parameter alone.References
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2. Gelber RH. Leprosy. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, eds. Harisson’s principles of internal medicine.18th ed. New York: Mc-Graw Hill, 2012:1359-67.
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4. Sharma A, Sharma RK, Goswsami KC, Bardwaj S. Clinico-Histopathological Correlation in Leprosy. JK Science 2008;10(3): 120-123.
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6. Dyavannanavar V, Belagatti S,Shashikant.Clinical and Histopathological Correlation in Leprosy: A Tertiary care hospital based study. International Journal of Healthcare Sciences 2015;3(1):265-269.
7. Banushree CS, Bhat RV, Udayashankar C. Clinicopathological correlation of Hansen’s disease: a retrospective study of skin biopsies. Indian Journal of Pathology and Oncology 2016; 3(3): 491-495.
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9. Kumar A, Negi SR, Vaishnav K. A study of Clinico-histopathological correlation of leprosy in a tertiary care hospital in western district of Rajasthan. J Res Med Den Sci 2014; 2(3): 43-8.
10. Mathur MC, Ghimire RBK, Shrestha P, Kedia SK .Clinicohistopathological Correlation in Leprosy. Kathmandu Univ Med J 2011;36(4): 248-51.
11. K N Shivaswamy, A L Shyamprasad, T K Sumathy, C Ranganathan,Agarwal V.Clinico histopathological correlation in leprosy. Dermatology Online Journal 2012;18 (9): 1-4.
12. Kumar R, Singhasivanon P, Sherchand JB, Mahaisavariya P, Kaewkungwal J, Peerapakorn Set al.Gender difference in socio-epidemiological factors for leprosy in the most hyper-endemic district of Nepal. Nepal Med Coll J 2004; 6(2): 98-105.
13. Rizvi AA, Sharma YK, Dash K,Tyagi N, Yadava R, Sadana D. An epidemiological and clinicohistopathologica lstudy of leprosy in semi-urban area under PimpriChinchwad Municipal Corporation in Pune district of Maharashtra.Med J DY Patil Univ 2015;8(5): 609-13.
14. Bijjaragi S, Kulkarni V, Suresh KK, Chatura KR and Kumar P. Correlationof clinical and histopathological classification of Leprosy in post elimination era. Indian J Lepr 2012;84 :271-275.
15. Premalatha P, Renuka IV, Meghana A, Devi SI, Charyulu PAVK, Sampoorna G. Utility of bacillary index in slit skin smears in correlation with clinical and histopathological alterations in hansen's disease: An attempt to revive a simple useful procedure. Ann Med HealthSci Res 2016; 6(3):181-4.
16. Nadia S, Rashmi J, Sohaib A, Rawat SDS, Thamarai NS, Meena H.Clinicopathological Correlation of Leprosy: A 4 years retrospective study from a tertiary referral centre in North India. Int J Med Res Health Sci. 2015; 4(2): 350-354.
17. Shenoi SD, Corre SK. Clinical and histopathological features in untreated macular lesions of leprosy – A study of 100 cases. Ind J Lepr 1988; 60(2): 202-5.
18. Thapa DP, Jha AK. Clinico-Histopathological Correlation in Leprosy:A Tertiary care hospital based study. Our Dermatol Online 2013; 4(3): 294-296.
19. Giridhar M, Arora G, Lajpal K and Chahal K S (2012). Clinicohistopathologicalconcordance in Leprosy - A Clinical, Histopathological and Bacteriological study of 100 cases. Indian J Lepr2012 ;84: 217-225
20. Kar PK, Arora PN, Ramasastry CV et al (1994). A clinico-Pathological study of Macular lesions in Leprosy. Indian J Lepr. 66: 435-442.
21. McDougall AC, Ponnighaus J and Fine PE (1987). Histopathological examination of skin biopsies from an epidemiological study of leprosy in northern Malawi. Int J Lepr Other Mycobact Dis. 55: 88-98.
2. Gelber RH. Leprosy. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, eds. Harisson’s principles of internal medicine.18th ed. New York: Mc-Graw Hill, 2012:1359-67.
3. Shivamurthy V, Gurubasavaraj H, Shashikala PS, Kumar P. Histomorphological study of leprosy. Afr J Med Health Sci 2013;12(2):68-73.
4. Sharma A, Sharma RK, Goswsami KC, Bardwaj S. Clinico-Histopathological Correlation in Leprosy. JK Science 2008;10(3): 120-123.
5. Manandhar U, Adhikari RC, Sayami G. Clinico-histopathological correlation of skin biopsies in leprosy. Journal of pathology of Nepal 2013; 3: 452-458.
6. Dyavannanavar V, Belagatti S,Shashikant.Clinical and Histopathological Correlation in Leprosy: A Tertiary care hospital based study. International Journal of Healthcare Sciences 2015;3(1):265-269.
7. Banushree CS, Bhat RV, Udayashankar C. Clinicopathological correlation of Hansen’s disease: a retrospective study of skin biopsies. Indian Journal of Pathology and Oncology 2016; 3(3): 491-495.
8. Gillis W, Rouge B. Survey of Newly Diagnosed Leprosy Patients in Native and Foreign Residents of Japan. International Journal of Leprosy 2000; 68(2): 172-176.
9. Kumar A, Negi SR, Vaishnav K. A study of Clinico-histopathological correlation of leprosy in a tertiary care hospital in western district of Rajasthan. J Res Med Den Sci 2014; 2(3): 43-8.
10. Mathur MC, Ghimire RBK, Shrestha P, Kedia SK .Clinicohistopathological Correlation in Leprosy. Kathmandu Univ Med J 2011;36(4): 248-51.
11. K N Shivaswamy, A L Shyamprasad, T K Sumathy, C Ranganathan,Agarwal V.Clinico histopathological correlation in leprosy. Dermatology Online Journal 2012;18 (9): 1-4.
12. Kumar R, Singhasivanon P, Sherchand JB, Mahaisavariya P, Kaewkungwal J, Peerapakorn Set al.Gender difference in socio-epidemiological factors for leprosy in the most hyper-endemic district of Nepal. Nepal Med Coll J 2004; 6(2): 98-105.
13. Rizvi AA, Sharma YK, Dash K,Tyagi N, Yadava R, Sadana D. An epidemiological and clinicohistopathologica lstudy of leprosy in semi-urban area under PimpriChinchwad Municipal Corporation in Pune district of Maharashtra.Med J DY Patil Univ 2015;8(5): 609-13.
14. Bijjaragi S, Kulkarni V, Suresh KK, Chatura KR and Kumar P. Correlationof clinical and histopathological classification of Leprosy in post elimination era. Indian J Lepr 2012;84 :271-275.
15. Premalatha P, Renuka IV, Meghana A, Devi SI, Charyulu PAVK, Sampoorna G. Utility of bacillary index in slit skin smears in correlation with clinical and histopathological alterations in hansen's disease: An attempt to revive a simple useful procedure. Ann Med HealthSci Res 2016; 6(3):181-4.
16. Nadia S, Rashmi J, Sohaib A, Rawat SDS, Thamarai NS, Meena H.Clinicopathological Correlation of Leprosy: A 4 years retrospective study from a tertiary referral centre in North India. Int J Med Res Health Sci. 2015; 4(2): 350-354.
17. Shenoi SD, Corre SK. Clinical and histopathological features in untreated macular lesions of leprosy – A study of 100 cases. Ind J Lepr 1988; 60(2): 202-5.
18. Thapa DP, Jha AK. Clinico-Histopathological Correlation in Leprosy:A Tertiary care hospital based study. Our Dermatol Online 2013; 4(3): 294-296.
19. Giridhar M, Arora G, Lajpal K and Chahal K S (2012). Clinicohistopathologicalconcordance in Leprosy - A Clinical, Histopathological and Bacteriological study of 100 cases. Indian J Lepr2012 ;84: 217-225
20. Kar PK, Arora PN, Ramasastry CV et al (1994). A clinico-Pathological study of Macular lesions in Leprosy. Indian J Lepr. 66: 435-442.
21. McDougall AC, Ponnighaus J and Fine PE (1987). Histopathological examination of skin biopsies from an epidemiological study of leprosy in northern Malawi. Int J Lepr Other Mycobact Dis. 55: 88-98.
Published
2019-04-30
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