Metaplastic carcinoma of the breast
A report of two cases
Keywords:
Breast, metaplastic carcinoma, heterogenous malignancy, triple negative tumors.
Abstract
Metaplastic carcinoma of the breast is a rare tumor which accounts for less than 1% of all the primary breast malignancies. It commonly occurs in women more than 50 years of age and are usually triple negative tumors with basal like subtype. Metaplastic carcinomas of breast have a very aggressive behaviour resulting in worse prognosis and a dismal disease free survival. However most metaplastic carcinomas express EGFR, therefore early and correct diagnosis benefits the patient to receive anti-EGFR drugs like cetuximab and geftinib. We are reporting two cases of metaplastic carcinomas, one with spindle cell differentiation and the other with squamous differentiation.References
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2. Tse GM, Tan PH, Putti TC, Lui PCW, Chaiwun B, Law BKB. Metaplastic carcinoma of the breast: a clinicopathological review. J Clin Pathol. 2006 Oct 1;59(10):1079–83.
3. Böler DE, Kara H, Sağlıcan Y, Tokat F, Uras C. Metaplastic carcinoma of the breast: A case series and review of the literature. J Oncol Sci. Elsevier; 2016 Aug 1;2(2–3):38–42.
4. (PDF) WHO Classification of tumors of the breast, 2012. 2012. p. 2–63.
5. Iqbal B, Kumar H, Kambale T, Baravkar A. Triple-negative metaplastic breast carcinoma with extensive squamous differentiation in a 55-year-old woman: A rare entity. Clin Cancer Investig J. Medknow Publications and Media Pvt. Ltd.; 2017;6(4):194.
6. Piscuoglio S, Ng CKY, Geyer FC, Burke KA, Cowell CF, Martelotto LG, et al. Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast. NPJ breast cancer. Nature Publishing Group; 2017;3:48.
Published
2019-10-01
Issue
Section
Case Report
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