Histopathological Study of Tumor and Tumor Like Lesions of the Oral Cavity

  • Babai Halder Mamata Medical College, Rotary Nagar, Khammam-507002. Telangana. India
  • Nirvana Rasaily Halder Mamata Medical College, Rotary Nagar, Khammam-507002. Telangana. India
Keywords: oral cavity, benign lesion, malignant lesion, squamous cell carcinoma


Background: The oral cavity is one of the most common site for various tumor and tumor like lesions. Development of oral cavity lesions are strongly linked with smoking. Hemangioma is the commonest benign tumor. Inflammatory fibrous hyperplasia is the commonest non-neoplastic reactive lesion. Squamous cell carcinoma (SCC) is most common among malignant lesions. Aims & Objectives: To study the histopathological patterns & variations of oral cavity lesions. Materials and methods: A three year retrospective cross-sectional study by histopathological examination. Results: A total of 105 cases were subjected to histopathological examination. Among these, 28 cases (26.66%) were benign, 27 cases (25.71%) were malignant and 4 cases (3.80%) were pre-malignant lesions. Among the malignant lesions, SCC was most common (85.19% ), while inflammatory fibrous hyperplasia was most common among non- neoplastic lesions ( 45.65 %). Overall females were affected more than males (M: F=1: 1.1), though malignant lesions were more common in males. Malignant lesions were more common in older age group (mean age 52.26%), while non-neoplastic lesions were common in younger age group (mean age 37.87%). Malignant lesions were most common in tongue (11 cases, 40.74 %), while benign lesions were most common in gingiva (10 cases, 35.71 % ). Conclusion: A variety of benign and malignant tumors occur in oral cavity. However, the origin and nature of the oral cavity lesions cannot be confirmed by clinical examination alone. Hence, histopathological examination is essential to confirm the diagnosis and malignant potential of the oral cavity lesions.

Author Biographies

Babai Halder, Mamata Medical College, Rotary Nagar, Khammam-507002. Telangana. India
Department of Pathology
Nirvana Rasaily Halder, Mamata Medical College, Rotary Nagar, Khammam-507002. Telangana. India
Department of Pathology


1. Vogel DWT, Zbaeren P, Thoeny HC. Cancer of the Oral cavity and Oropharynx. Cancer Imaging 2010;10:62-72.

2. Schulman JD, Beach MM, Rivera-Hidalgo F. The prevalence of oral mucosal lesions in U.S. adults: data from the Third National Health and Nutrition Examination Survey, 1988-1994. J Am Dent Assoc 2004; 135:1279-86.

3. Mark W. Lingen and Vinay Kumar. Head & Neck (Oral Cavity), A Text Book of Robins and Cotran. Pathologic Basis of Disease. 7th ed. India: Elsevier; 2004. p.774-82.

4. Nikunj V.M, Kalpana K. Dave, R.N. Gonsai et al. Histopathological study of oral cavity lesions: A study of 100 cases. Int J Cur ResRev 2013;5(10):110-6.

5. Shafer. Benign and Malignant Tumors of Oral Cavity, A Text book of oral pathology, 4th edn. Harcourt Indian Pvt. Ltd. W.B. Saunder’s Co., 1993. p. 86-215.

6. Bouquot JE. Common oral lesions found during a mass screening examination. J Am Dent Assoc 1986;112:50-7.

7. PN Ramachandrau Naiv, Giou Pajarola. Types and incidence of human periapical lesions obtained with extracted teeth. Oral Surg Oral Med Oral Path Oral Radio Endod 1996;81:93-102.

8. Adelberto Mosquedo, Taylor Coustantino Ledeswa, Montes Silivia Caballero, et al. Odontogenic tumors in Mexico A collaborative retrospective study of 349 cases. Oral Surg Oral Med Oral Path Oral Radio Endod.1997;84:672-5.

9. Kramer IRH, Pindborg JJ, Shar M. Histological typing of odontogenic tumors. World Health Organization—international histological classification of tumors. 2nd ed. Berlin, Germany: Springer-Verlag; 1992.p.1–42.

10. Weber AL, Bui C, Kaneda T. Malignant tumors of the mandible and maxilla. Neuroimaging Clin N Am 2003;13(3):509–24.

11. Ayaz B, Saleem K, Azim W, Shaikh A. A clinincopathological study of oral cancers. Biomedica 2011;27:29-32.

12. Singh AD. Challenge of Oral Cancer in India. Indian J Radiol 1981;35(3):147-55.

13. Kashyap P, Sridhar P, Nalini P. Reactive lesions of the oral cavity: Contemp Clin Dent 2012;3(3):294.

14. Fang QG, Shuang S, Zhen NL, Zhang X, Liua FY, Zhong F et al. Squamous cell carcinoma of the buccal mucosa: Analysis of clinical presentation, outcome and prognostic factors. Mol Clin Oncol 2013;1:531-4.

15. Mehta NV, Dave KK, Gonsai RN, Goswami HM, Patel PS, Kadam TB.Histopathological study of oral cavity lesions. IJCRR 2013;5(10):110-6.

16. Dhanuthai K, Rojanawatsirivej S, Thosaporn W, Kintarak S, Subarnbhesaj A, Darling M et al. Oral cancer: A multicenter study. Med Oral Patol Oral Cir Bucal. 2018;23(1):e23-9.

17. Shah PY, Patel RG, Prajapati SG. Histopathological study of malignant lesions of oral cavity. Int J Med Sci Public Health 2017;6(3):472-8.

18. Kumar M, Nanavati R, Modi TG, Dobariya C. Oral cancer: Etiology and risk factors: A review. J Can Res Ther 2016;12:458-63.

19. Halboub ES, Abdulhuq M , Al-Mandili A.  Oral and pharyngeal cancers in Yemen:a retrospective study: EMHJ 2012;18(9):985-91.

20. Allon I, Kaplan I, Gal G, Chaushu G, Allon DM. The clinical characteris- . The clinical characteris The clinical characteristics of benign oral mucosal tumors. Med Oral Patol Oral Cir Bucal 2014;19(5):e438-43.

21. Jagtap SV, Warhate P, Saini N, Jagtap SS, Chougule PG. Oral premalignant lesions: a clinicopathological study. Int Surg J 2017;4:3477- 81.
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