Histomorphological Study of The Spectrum of Prostatic Lesions in Surgical Biopsy Specimens
Keywords:
Prostatic lesions, Prostatic adenocarcinoma, Prostatitis, TURP, Benign Prostatic Hyperplasia
Abstract
Background: Prostatism is one of the commonest health concerns in geriatric population with significant morbidity and mortality. The incidence of it increases with age. Histopathological evaluation plays a major role in the diagnosis and management of Prostate lesions. Aims and Objectives: To study the spectrum of prostate specimens encountered by the pathologists and to categorize them based on their histomorphological features and to correlate it with the clinical and other laboratory parameters. Material and methods: Hematoxylin and Eosin sections of 100 prostatic biopsies received in the department of Pathology of a tertiary care centre over a period of 18 months were studied. Relevant clinical and laboratory data were collected. Results: Out of 100 prostatic biopsies studied, 91 were TURP and 9 were core biopsies. Prostatic lesions was common in the age group of 61-70 years. 75% of cases were benign with or without prostatitis, 15% malignant and 10% cases were pre malignant. 25% cases were found to have associated prostatitis with the benign and malignant lesions. The most common microscopic feature in benign cases was fibromuscular hyperplasia. Conclusion: The present study shows that benign lesions are more common than the malignant ones. Among benign lesions, BPH was the most common entity. The most common age group affected was 7th decade.References
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2. Guadin PB, Sesterhenn IA, Wojno KJ, Mostofi FK, Epstein JI. Incidence and clinical significance of high-grade prostatic intraepithelial neoplasia in TURP specimens. Urology. 1997 Apr 1;49(4):558-63.
3. Khan M, Khan AL, Khan S, Nawaz H. Benign prostatic hyperplasia: mode of presentation and postoperative outcome. JPMA. 2005 Jan;55(1):20-3.
4. Puttusamy K, Parthiban R, Shariff S. Histopathological study of prostatic biopsies in men with prostatism. J Med Sci. 2016 Jan;2(1):12.
5. Josephine A. Clinicopathological study of prostatic biopsies. JCDR. 2014 Sep 1;8(9):FC04-06.
6. George E, Thomas S. A Histopathologic Survey Of Prostate Disease In The Sultanate Of Oman. Int J Pathol. 2004;3(2).
7. Chandanwale S, Jadhav SP, Anwekar CS, Kumar H, Buch CA, Chaudhari SU. Clinicopathological study of benign and malignant lesions of prostate. IJPBS. 2013 Jan 1;3(1):162-78.
8. Subathra K, Sangeetha N. Histopathological study of prostatic lesions and assessment with agnor index. Ind J Pharm Bio Sci. 2014 Apr 1;5(2):253-60.
9. Joshee A, Sharma KC. The histomorphological study of prostate lesions. IOSR-JDMS. 2015 Nov 1;14:85-9.
10. Bostwik DG, Amin MB,. Male reproductive system. In: Damjanov I, Linder J. editors. Anderson’s pathology. Vol.1, 10th Ed., Missouri: Mosby; 1996.p.2197-222.
Published
2019-10-01
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