A Study of p53 immunostaining in prostate carcinomas: Correlation with Gleason’s score

  • Roopa Urs A.N PK Das Institute of Medical Sciences, Vaniamkulam, Palakkad
  • Manjunath G V JSS Medical College, Mysore, India
  • Suchitha S JSS Medical College, Mysore
  • Hugara Siddalingappa Mandya Institute of medical Sciences, Mandya India
Keywords: Prostate cancer, Gleason’s score, p53


Background: Prostate cancer is the second most common cause of cancer and the sixth leading cause of cancer death among men worldwide. In view of the above, early diagnosis and effective treatment of the disease are immensely important. The increasing number of options for the treatment of prostate cancer has made the prognostic evaluation of the disease even more important. P53 is a tumor suppressor gene characterised by a highly proliferative pattern and an aggressive behaviour. The Objectives was to study the immunostaining patterns of p53 in prostate cancers and to compare the results with Gleason's score. Methods: Fifty cases of histopathologically proven prostate carcinomas diagnosed on needle biopsies and transurethral resection specimens was studied in JSS medical college and hospital, mysore for a period of 3 years and histopathological grade was assessed using Gleason grading system. Immunohistochemistry (IHC) for p53 was done on paraffin embedded wax sections. Result: p53 staining was positive in 47(94%) cases out of 50 cases, three (6%) cases were negative. Although there was an increase in positive p53 staining with increased Gleason’s score, it was not statistically significant (‘p’ value = 0.068). Conclusion: p53 is a tumor suppressor gene, that express high proliferative pattern. It can be used as a prognostic factor. The immunoreactivity of p53 marker with increased tumor grade can benefit patients with appropriate targeted treatment and increase their survival period.

Author Biographies

Roopa Urs A.N, PK Das Institute of Medical Sciences, Vaniamkulam, Palakkad
Department of Pathology
Manjunath G V, JSS Medical College, Mysore, India
Department of Pathology
Suchitha S, JSS Medical College, Mysore
Department of Pathology
Hugara Siddalingappa, Mandya Institute of medical Sciences, Mandya India
Department of Community Medicine


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