A Study of Serum Iron Profile in Patients with Chronic Kidney Disease

  • Indira Shastry American University of Antigua College of Medicine, West Indies
  • Sushma Belurkar Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
Keywords: Chronic Kidney Disease, Serum Iron, TIBC, Ferritin

Abstract

Background: Even though anemia and iron deficiency can increase the morbidity and mortality in patients with chronic kidney disease (CKD), an iron overload can be dangerous as well. Aim: Identify the number of CKD patients with iron deficiency, iron overload, acute phase reaction and anemia of chronic disease in a tertiary care hospital. Material and methods: The study was conducted in Kasturba medical college, Manipal. 154 patients with CKD were selected for the study irrespective of their treatment status with hematinics and/or erythropoietin. Results: The mean total serum iron levels were 61μg/dl, Total Iron Binding Capacity (TIBC) 216.43 μg/dl, serum ferritin 539.68 μg/dl, and transferrin saturation of 32.18% respectively. When the serum iron profile of individuals was analyzed, majority (54.25%) of the patients were found to have acute phase reaction and most of them were in advanced stage of renal failure. Normal serum iron profile was found in 37.2% patients, iron overload in 2.2%, anemia of chronic disease in 5.3% and iron deficiency in 1% cases. These findings were statistically significant with the P value of 0.001. Conclusion: Most common type of serum iron profile found in the study population was acute phase reaction (54%) and majority of them were in stage 5 renal failure. Hence, before beginning an iron therapy, all the patients with anemia in chronic kidney disease should be evaluated for body iron status to prevent iron overload.

Author Biographies

Indira Shastry, American University of Antigua College of Medicine, West Indies
Department of Pathology
Sushma Belurkar, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
Department of Pathology

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Published
2020-07-02
Section
Original Article