The Relationship Between Serum Levels Of CA- 125 and Interleukin -6 with the Degree of Differentiation in Ovarian Neoplasms
Keywords:
Ovarian neoplasm, CA-125, Interleukin-6
Abstract
Background: To study the serological correlation between serum levels of CA -125 and IL-6 with various histo morphological features of ovarian neoplasm. Methods: Prospective study of two year duration from 2016 to 2018.Total of 40 women presented clinically with pelvic mass lesion were included. These patients undergoing concomitant serological analysis of CA -125 and IL-6. In each case, age, parity, marital life, radiological finding, histological type, degree of differentiation, extra ovarian tissues involvement was determined. Result: Most of the ovarian neoplasm belongs to benign category 19/40 (47.5%) then malignant tumors 15/40 (37.5%). Surface epithelial tumours (80%) were common histopathological findings with raised CA-125 and Interleukin-6 levels. Most of the patient present with abdominal pain in their late reproductive age group (41-60 years). There is significant correlation ( p-value=.000) in rise of levels of CA-125 and Interleukin-6 levels in patients with benign and malignant ovarian lesion. Levels of both the biomarkers are near normal levels in benign cases and levels were raised in malignant cases. Conclusion: Amongst the ovarian neoplasm benign tumor were more common than malignant with predominance histological type is surface epithelial tumors. Serum levels of CA –125 and IL-6 were associated with histological grade in primary ovarian neoplasms, especially in high-grade malignant tumors, suggesting that high serological levels of these biomarkers are associated with lesions of more aggressive biological behavior.References
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17. 17. Ahmad Z, Kayani N, Hasan SH, Muzaffar S, Gill MS. Histological pattern of ovarian neoplasm. J Pak Med Assoc 2000; 50: 416-9.
18. Rathi V et al Study Of Histopathological Spectrum Of Ovarian Lesions, Vikram University,Ujjain,2005.
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24. Outwater EK, Siegelman ES, Kim B, Chiowanich P, Blasbalg R, Kilger A. Ovarian Brenner tumours: MR imaging characteristics. Magn Reson Imaging 1998;16:1147–53
25. Herbst AL. The Epidemiology of Ovarian Carcinoma and the Current Status of Tumour Markers to Detect Disease. Am JObstet Gynecol 1994;170:1099–107.
26. Di Bonito L, Patriarca S, Delendi M, Alberico S. Ovarian tumours: anatomohistopathological contribution to their interpretation. Eur J Gynaecol Oncol 1988; 9: 324-30.
27. Chakrabortti DK, Lee CMS. Epidemiological study ovarian neoplasms. J Obstet gynaecol India 1990; 40:582 -6.
28. Greggi S, Parazzini F, Paratore MP, Chatenoud L, Legge F, Mancuso S et al. Risk factors for ovarian cancer in central Italy. Gynecol Oncol 2000; 79:50-4.
29. Salazar-Martinez E, Lazeano-Pance EC, Gonzalez Lira-Lira G, Escudero- De Los Rios P, Salmeron-Castro J, Hernandez-Avila M. Cancer Res 1999; 59:3658-62.
30. Yen ML, Yen BL, Bai CH, Lin RS. Risk factors for ovarian cancer in Taiwan: a case control study in a low incidence population. Gynecol Oncol 2003; 89: 318-24.
31. Zhang M, Lee AH, Binns CW. Reproductive and dietary risk factors for epithelial ovarian cancer in China. Gynecol Oncol 2004; 92: 320-6
32. KOLWIJICK, E. et al. Preoperative CA-125 level in 123 patients with borderline ovarian tumors: a retrospective analysis and review of the literature. Int J Gynecol Cancer, v. 19, n. 8, p. 1335-8, 2009.
33. OSMAN, N. et al. Correlation of serum CA125 levels with stage, grade and survival of patients with epithelial ovarian cancer. J Clin Oncol, v. 25, n.18, suppl. 16006, 2007.
2. Adelmen S, Benson CD, Hertzler JH, surgical lesion of the ovary in infancy & childhood, surggynecolobstate 1975, 141 : 219-222
3. Gupta N, Bisht D, Agrawal AK, Sharma UK, Comoarative study of ovarian cyst and tumour, J Pak Medical association December 2000,50(12);416-419.
4. Scully RE, Clement PB, Young RH, Miscellaneous primary tumours, secondary tumours, and non-neoplastic lesions of ovary. In : Mills SE, Carter D, Greenson JK, Oberman HA, Renter V, Stoler MH edts. Sternberg's diagnostic surgical pathology, 4th edn. Philadelphia : Lippincott Williams and Wilkins; 2004.p.2617
5. Zurawski VR, Jr, Orjaseter H, Andersen A, Jellum E. Elevated serum CA 125 levels prior to diagnosis of ovarian neoplasia: relevance for early detection of ovarian cancer. Int J Cancer. 1988;42:677–680. [PubMed]
6. Lidor YJ, Xu FJ, Martinez-Maza O, Olt GJ, Marks JR, Berchuck A, et al.Constitutive production of macrophage colony-stimulating factor and interleukin-6 by human ovarian surface epithelial cells. Exp Cell Res.1993;207(2):332–9. doi:10.1006/excr.1993.1200.
7. Watson JM, Berek JS, Martinez-Maza O. Growth inhibition of ovarian cancer cells induced by antisense IL-6 oligonucleotides. Gynecol Oncol.1993;49(1):8–15. doi:10.1006/gyno.1993.1077.
8. Lo CW, Chen MW, Hsiao M, Wang S, Chen CA, Hsiao SM, et al. IL-6 transsignaling in formation and progression of malignant ascites in ovarian cancer. Cancer Res. 2011;71(2):424–34. doi:10.1158/0008-5472.can-10-1496.
9. Friedman, EL, Hayes, DF, Kufe, DW. Reactivity of monoclonal antibody DF3 with a high molecular weight antigen expressed in human ovarian carcinomas. Cancer Res. 1986;46:5189–5194.
10. Bast, RC Jr, Knauf, S, Epenetos, A et al, Coordinate elevation of serum markers in ovarian cancer but not in benign disease. Hybridoma. 1987;6:228.
11. Gruhn JG. A selected historical survey pathology emphasizing neoplasms. In: Roth LM, Czernobilsky B (eds). Tumours and Tumour-like Conditions of the Ovary (Chapter 13). Churchill Livingstone: New York, 1985.
12. Graham H. Eternal Eve. The History of Gynaecology and Obstetrics. Doubleday and Company, Inc.: New York, 1951.
13. Pilli GS, Suneeta KP, Dhaded AV, Yenni VV. Ovarian tumours: a study of 282 cases. J Indian Med Assoc 2002; 100: 420, 423-4, 447.Morgagni GB. The Seats and Causes of Diseases (English Translation by Benjamin Alexander). Miller A, Cadell T and Johnson and Payne: London, 1769.
14. Ahmad Z, Kayani N, Hasan SH, Muzaffar S, Gill MS. Histological pattern of ovarian neoplasm. J Pak Med Assoc 2000; 50: 416-9.
15. Oumachigui, Narasimhan KL, Reddy KS, et al. A clinicopathologic study of ovarian tumours in children. J Obstet Gynecol. 1991;140:441–5.
16. Pilli GS, Suneeta KP, Dhaded AV, Yenni VV. Ovarian tumours: a study of 282 cases. J Indian Med Assoc 2002; 100: 420, 423-4, 447.
17. 17. Ahmad Z, Kayani N, Hasan SH, Muzaffar S, Gill MS. Histological pattern of ovarian neoplasm. J Pak Med Assoc 2000; 50: 416-9.
18. Rathi V et al Study Of Histopathological Spectrum Of Ovarian Lesions, Vikram University,Ujjain,2005.
19. Koonings PP, Campbell K, Mishell DR Jr, Grimes DA. Relative frequency of primary ovarian neoplasms: a10 year review. Obstet Gynaecol 1989; 74: 921-26
20. Rafiq B, Kokab H, Rao SI. Ovarian tumours. Professional Med J 2005;12(4):397–403.
21. R Jha& S Karki , Nepal Medical College,Journal 2008:109(2)81-85.
22. Levi1 F, Vecchia CL, Randimbison L, Te VC. Borderline ovarian tumours in Vaud. Switzerland: incidence, survival and second neoplasms. Br J Cancer 1999;79(1):4–6
23. Burkholz KJ, Wood BP, Zuppan C. Best Cases from the AFIP: Borderline papillary serous tumour of the right ovary. Radiographics 2005;25:1689–92.
24. Outwater EK, Siegelman ES, Kim B, Chiowanich P, Blasbalg R, Kilger A. Ovarian Brenner tumours: MR imaging characteristics. Magn Reson Imaging 1998;16:1147–53
25. Herbst AL. The Epidemiology of Ovarian Carcinoma and the Current Status of Tumour Markers to Detect Disease. Am JObstet Gynecol 1994;170:1099–107.
26. Di Bonito L, Patriarca S, Delendi M, Alberico S. Ovarian tumours: anatomohistopathological contribution to their interpretation. Eur J Gynaecol Oncol 1988; 9: 324-30.
27. Chakrabortti DK, Lee CMS. Epidemiological study ovarian neoplasms. J Obstet gynaecol India 1990; 40:582 -6.
28. Greggi S, Parazzini F, Paratore MP, Chatenoud L, Legge F, Mancuso S et al. Risk factors for ovarian cancer in central Italy. Gynecol Oncol 2000; 79:50-4.
29. Salazar-Martinez E, Lazeano-Pance EC, Gonzalez Lira-Lira G, Escudero- De Los Rios P, Salmeron-Castro J, Hernandez-Avila M. Cancer Res 1999; 59:3658-62.
30. Yen ML, Yen BL, Bai CH, Lin RS. Risk factors for ovarian cancer in Taiwan: a case control study in a low incidence population. Gynecol Oncol 2003; 89: 318-24.
31. Zhang M, Lee AH, Binns CW. Reproductive and dietary risk factors for epithelial ovarian cancer in China. Gynecol Oncol 2004; 92: 320-6
32. KOLWIJICK, E. et al. Preoperative CA-125 level in 123 patients with borderline ovarian tumors: a retrospective analysis and review of the literature. Int J Gynecol Cancer, v. 19, n. 8, p. 1335-8, 2009.
33. OSMAN, N. et al. Correlation of serum CA125 levels with stage, grade and survival of patients with epithelial ovarian cancer. J Clin Oncol, v. 25, n.18, suppl. 16006, 2007.
Published
2019-08-08
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