Rare Incidental Detection Of Bombay Blood Group In A Patient Of Marfans Syndrome With Subsequent Clustering And Unusual Inheritance Pattern In Four Individuals Of Same Family In South West Region Of Punjab
Keywords:
rare blood group, Bombay Blood Group
Abstract
The Bombay Blood Group (Oh) is characterized by absence of normal ABH antigens and presence of corresponding antibodies in serum. This blood group is suspected when a sample doesn’t show any reaction to anti-A and anti-B antibodies just like a normal O group would do but shows agglutination in reverse grouping or during antibody screening. Present case report highlights a case of 25 year old female who was incidentally detected having Bombay blood group and on further evaluation, one sibling and two first degree cousins were also detected having Bombay blood group. Such a clustering of Bombay blood group cases in a single-family is very rare and has never been reported in Punjab as per literature.References
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2. Das S, Kumar HRA. Bombay Blood A Rare Entity. Journal of Clinical Biomedical Science. 2011;1(3):122–5.
3. Khan M. Bombay Blood Group: A Case Report. The Pacific Journal of Science and Technology. 2009 May;10(1):333–7.
4. Bombay Blood Group in a Turkish Family: Serological and Molecular Analysis. Aytac R et al. Indian Journal of Hematology and Blood Transfusion. 2015;31(3):396–7.
5. Kelly RJ, Rouquier S, Giorgi D, Lennon GG, Lowe JB. Sequence and expression of a candidate for the human secretor blood group a-(1,2)-fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates withthe nonsecretor phenotype. J Biol Chem. 1995;270:4640–9.
6. Larsen RD, Ernst LK, Nair RP, Lowe JB. Molecular cloning, sequence, and expression of a human GDP-L-fucose: b-D- galactoside 2-a-L-fucosyltransferase cDNA that can form the H blood group antigen. Proc Natl Acad Sci USA. 1990; 87:6674–8.
7. Saran RK. Transfusion Medicine: Technical Manual. Directorate General of Health
Services, Ministry of Health and Family Welfare, Government of India; 2003.
8.Aust CH et al. A family of Bombay blood type with suppression of blood group substance A1. The American Journal Of Clinical Pathology. 1962; 37(6):579-83.
9. Rıza Aytaç Çetinkaya, Soner Yılmaz, Davut Gül, Sebahattin Yılmaz, İsmail Yaşar Avcı,, Can Polat Eyigün Bombay Blood Group in a Turkish Family: Serological and Molecular Analysis. Indian Journal of Hematology and Blood Transfusion. 2015; 31(3): 396–7.
Published
2020-01-31
Issue
Section
Case Report
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