Study of Serum Homocysteine Level in Young Patients with Myocardial Infarction and Cerebrovascular Stroke
Keywords:
Homocysteine, Myocardial Infarction, Ischemic stroke, coronary artery disease
Abstract
Background: Nowadays, vascular disease is the leading cause of death and disability. India too is facing epidemic of cardiovascular and cerebrovascular disease. The established risk factors for heart disease and stroke account for one half to three fourth of cases. The remainders are the result of other factors that promote atherosclerosis. Elevated blood levels of homocysteine have been linked to increased risk of premature coronary artery disease, stroke and thromboembolism, even among people who have normal cholesterol levels. Hence screen for homocysteine is recommended in patients with premature atherosclerotic disease and unexplained venous thrombosis. Methods: The present study was performed to correlate the levels of serum homocysteine levels in young patients (</=40 yrs) with myocardial infarction and ischemic cerebrovascular stroke. Thirty cases were studied along with assessment of their risk factor. Result: It was observed that serum homocysteine levels were significantly raised in coronary artery disease and ischemic stroke patients. Conclusion: Increase levels of homocysteine is an important factor that assesses risk independently for coronary artery disease and ishchemic stroke.References
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[2] Braunwald-6th edition. Heart disease. A textbook of cardiovascular medicine.
[3] Donald W.J. Homocysteine and vitamins in cardiovascular disease. Clinical Chemistry. 1998; 44(8): 1833–1843
[4] Eikelboom JW et al. Homocysteine and cardiovascular disease. A critical review of the epidemiological evidence. Annals of Internal Medicine.131:363-375, 1999.
[5] Qujeq D, Omran TS, Hosini L. Correlation between total homocysteine, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the serum of patients with myocardial infarction. Clin Biochem. 2001; 34(2)97-101.
[6] A meta analysis. Homocysteine and risk of ischemic heart disease and stroke: JAMA 2002; 288:2015.
[7] Schwartz SM, Siscovick DS, Malinow MR, Rosendaal FR. MI in young women in relation to total plasma homocysteine. Circulation 1997 July 15:96(2):412-7.
[8] Jun-Hyun Y, Chin-Sang C, Soo-Sang K et al: Relation of plasma homocysteine to cerebral infarction and cerebral atherosclerosis: Stroke. 1998 Dec;29:2478–2483.
[9] Saikat D, Salil K.P, Hirak M et al. Homocysteine and cerebrovascular accidents; JIMA 2009; 107(6): 345-6.
Published
2019-12-01
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