A Review of Triple Negtive Marker of IHC in Medullary Carcinoma Breast
An Uncommon Substype with Good Prognosis
Keywords:
Medullary carcinoma breast, BIRADS II, triple negative IHC markers
Abstract
Medullary carcinoma of the breast is an uncommon variant of invasive ductal carcinoma, which constitutes nearly 5% of all breast cancers in men and women. These tumours are often associated with favourable prognosis despite showing aggressive behaviour. In this study a patient presented with history of breast lump aged 48 years in left breast since one year .In mammography it was described as BIRADS II and fine needle aspiration cytology showed suspicious for malignancy .Histopathology report showed medullary carcinoma breast lesion. Immunochemistry was also done for ER , PR and Her-2neu and it showed negative for ER ,PR and HER 2 Neu.References
1. J. Huober, S. Gilber , A Goldrich , A ,S Coates , G Viale , K.N Price , M.M Regan , Prognosis of medullar breast cancer . Analysis of 13 international breast cancer study group trials . Annals of Oncology 2012, 23 pg 2843-2851 .
2. Jagtap . S , Saini .N , Jagtap .S , Saini. S . Medullary carcinoma of breast , Case report . International J of health care and biomedical research , Volume 03 , issue 04 , 2015 , pg 55-58
3 N. Sajjan , V. BR , M. Srinivasa . Cytomorphological study of medullary carcinoma breast in comparison to infiltration Ductal carcinoma . Journal of cytology , 2018 , 35, 195-98
4. Tavasolli FA, Devilee P. World health organization classification of tumours, Pathology and genetics of tumours of breast and female genital organs. Lyon: IARC press; 2003.
5. . Saad RS, Silverman JF. Breast. In: Bibbo M, editor. Comprehensive Cytopathology. 2nd ed. Elsiever; 1997. p. 713‑72.
6. Gattuso P, Reddy V, David O, Spitz D, Haber M. Infiltrating carcinoma: Pathological types. In Differential Diagnosis in Surgical Pathology. 2nd ed.US Saunders, Elsevier ; 2010. p. 170-214.
7. Howat A, Coghill S. Malignant breast tumours. In: Winifred G, editor. Diagnostic cytopathology, 3rd ed. US Elsevier US;Churchill Livingstone; 2010. p. 279-302.
8. Marginean F, Rakha AE, Ho BC, Ellis IO, Lee AH. Histological features of medullary carcinoma and prognosis in triple negative basal like carcinomas of the breast. Modern Pathology 2010;23:1357‑63.
9. Kuroda H, Tamaru J, Sakamoto G, Ohnisi K, Itoyama S. Immunophenotype of lymphocytic infiltration in medullary carcinoma of the breast. Virchows Arch 2005;446:10‑4.
10. Ridolfi RL, Rosen PP, Port A, Kinne D, Mike V. Medullary carcinoma of the breast: A clinicopathological study with 10 year follow‑up. Cancer 1977;40:1365‑85.
11. Santosh T, Bal AK, Patro MK, Choudhaury A. Medullary Breast Carcinoma: A Case Report and Review of Literature. J Cancer Science There 2015;7: 142‑145.
2. Jagtap . S , Saini .N , Jagtap .S , Saini. S . Medullary carcinoma of breast , Case report . International J of health care and biomedical research , Volume 03 , issue 04 , 2015 , pg 55-58
3 N. Sajjan , V. BR , M. Srinivasa . Cytomorphological study of medullary carcinoma breast in comparison to infiltration Ductal carcinoma . Journal of cytology , 2018 , 35, 195-98
4. Tavasolli FA, Devilee P. World health organization classification of tumours, Pathology and genetics of tumours of breast and female genital organs. Lyon: IARC press; 2003.
5. . Saad RS, Silverman JF. Breast. In: Bibbo M, editor. Comprehensive Cytopathology. 2nd ed. Elsiever; 1997. p. 713‑72.
6. Gattuso P, Reddy V, David O, Spitz D, Haber M. Infiltrating carcinoma: Pathological types. In Differential Diagnosis in Surgical Pathology. 2nd ed.US Saunders, Elsevier ; 2010. p. 170-214.
7. Howat A, Coghill S. Malignant breast tumours. In: Winifred G, editor. Diagnostic cytopathology, 3rd ed. US Elsevier US;Churchill Livingstone; 2010. p. 279-302.
8. Marginean F, Rakha AE, Ho BC, Ellis IO, Lee AH. Histological features of medullary carcinoma and prognosis in triple negative basal like carcinomas of the breast. Modern Pathology 2010;23:1357‑63.
9. Kuroda H, Tamaru J, Sakamoto G, Ohnisi K, Itoyama S. Immunophenotype of lymphocytic infiltration in medullary carcinoma of the breast. Virchows Arch 2005;446:10‑4.
10. Ridolfi RL, Rosen PP, Port A, Kinne D, Mike V. Medullary carcinoma of the breast: A clinicopathological study with 10 year follow‑up. Cancer 1977;40:1365‑85.
11. Santosh T, Bal AK, Patro MK, Choudhaury A. Medullary Breast Carcinoma: A Case Report and Review of Literature. J Cancer Science There 2015;7: 142‑145.
Published
2019-10-01
Issue
Section
Case Report
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
