Synchronous Mucinous Tubular and Spindle Cell Carcinoma of the Kidney and Papillary Carcinoma of the Thyroid
Keywords:
Mucinous tubular spindle cell carcinoma, kidney tumors, classic papillary thyroid carcinoma, nephrectomy
Abstract
A 55 year old female, presented with flank pain and fullness since 2 years. On examination, a 10x10cm, ballotable lump was present in the right flank. CT Abdomen showed a 9.5x8.8 cm, exophytic mass lesion in the right kidney with patchy arterial enhancement and heterogenous enhancement in the venous phase. Whole body PET CT showed well defined, metabolically active masses in the right kidney, thyroid and cervical lymph nodes. Nephrectomy specimen received, showed a tumor measuring 12x7x6.5 cm creamy-white, fleshy, replacing the kidney. Histopathology revealed an unusual renal neoplasm with tubule formation merging with bland spindle cells and a focal myxoid stroma. Tumor cells were immunoreactive for CK7, EMA, vimentin and were negative for PAX8, CD10 & AMACR. The diagnosis of Mucinous Tubular and Spindle cell carcinoma (MTSCC) was established. FNAC of the thyroid nodules showed a classic papillary thyroid carcinoma.References
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3. Ferlicot S, Allory Y, Comperat F, et al. Mucinous tubular spindle cell carcinoma: a report of 15 cases and a review of literature. Virchows Arch. 2005; 447(6):978-983.
4. Thway K, du Parcq J, Larkin JM, et al. Metastatic renal mucinous tubular and spindle cell carcinoma. Atypical behavior of a rare, morphologically bland tumor. Ann Diagn Pathol. 2012; 16:407-410. PMID:21684183
5. Simon RA, di Sant’agnese PA, Palapattu GS, et al. Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid differentiation. Int J Clin Exp Pathol. 2008; 1:180-184. PMID:18784804
6. Cossu-Rocca P, Eble JN, Delahunt B, et al. Mucinous tubular spindle cell carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome Y that are prevalent in papillary renal cell carcinoma. Mod Pathol. 2006; 19: 488-493.
7. Rakozy C, Schmahl GE, Bogner S, Storkel S. Low-grade tubular-mucinous renal neoplsms: morphologic, immunohistochemical and genetic features. Mod Pathol. 2002; 15:1162-1171. PMID:12429795
8. Park SY, Kang GH, Black J, et al. Mucinous tubular spindle cell carcinoma of the kidney occurring in a patient with pulmonary adenocarcinoma. The Korean Journal of Pathology. 2008; 42:54-59.
9. Chien-Chang Li, Chen-Hui Lee, Yee-Jee Jan, et al. Renal mucinous tubular and spindle cell carcinoma with an aorto-caval mass mimicking metastatic lymphadenopathy. Journal of the Chinese Medical Association. 2012;75:240-242
Published
2020-03-07
Issue
Section
Case Report
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