Reactive Thrombocytosis – Aetiology And Relationship with Different Hematological Parameters, ESR, CRP in Infections
Keywords:
C-reactive protein, erythrocyte sedimentation rate, mean platelet volume, platelet count
Abstract
Background: The measurements of platelet count, mean platelet volume (MPV), WBC are routinely available nowadays. The aim of this study was to determine aetiology and relationship of these parameters whether they were associated with the known markers of disease activity, erythrocyte sedimentation rate (ESR) and C- reactive protein (CRP) in infections. Methods: This descriptive study was done on 500 patients with platelet count > 450,000/ μl and the cause being reactive. Platelet count, WBC, MPV, ESR, and CRP were measured at the time of hospitalization. Result: Most common cause of reactive thrombocytosis was Infections (28.8%), Tissue damage (16.4%), Iron deficiency anemia (16.2%), Malignancy (9.6%) and Inflammation (9.4%). In infections, bacterial infections (88%) were found to be more common. There was low degree of positive correlation between reactive thrombocytosis and WBC (r = 0.124, P >0.05) , ESR ( r = .147, P= 0.07) , MPV ( r = .077, P >0.05) in infections. There was significant negative correlation between reactive thrombocytosis and CRP in infections (r = -.199, P= 0.017). Conclusion: This study demonstrated a higher level of platelet count and lower MPV in all the patients having reactive thrombocytosis irrespective of it’s etiology. There was low degree of positive correlation between platelet count and WBC, ESR and MPV in infections and a significant negative correlation with CRP. We propose that platelet parameters may be considered as reliable markers for assessment of disease activity.References
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5. Nagai T, Komatsu N, Sakata Y, Miura Y, Ozawa K. Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. Intern Med 2005; 44: 1090-1092.
6. Baynes RD, Bothwell TH, Flax H et al - Reactive thrombocytosis in pulmonary tuberculosis. J Clin Pathol 1987; 40:676-679.
7. MC Donald TP. A comparison of platelet size, Platelet count 35s incorporation as assay for thrombopoietin. Br J Hematol 1978;38:257-67.
8. Omar M, Jogessar VR, Kamder MC. Thrombocytosis associated with tuberculosis peritonitis tubercle 1983; 64: 295-6.
9. Shaw AC. Serum C-reactive protein concentration in patient with viral or bacterial infection. J Clin Pathol. 1991; 44:546-599.
10. Peltola H, Holmberg C. Rapidity of C-reactive protein concentration in detecting potential septicaemia. Pediatr Infect Dis 1983; 2:374-6.
11. Mc Carthy PL, Frank AL, Ablow RC, Master SJ, Dolan TF Jr. C-reactive protein test in differentiation of bacterial and viral pneumonia. J Pediatr 1978; 92:454-6.
12. Rose PE, Johnson SA, Meakin M, Mackie PH, Stuart J. Serial study of C-reactive protein during infection in leukaemia. J Clin Pathol 1981; 34:263-6.
13. Rowe IF, Worsley AM, Donnelly P, Catvsky D, Goldman JM, Pepys HB. Measurement of serum C-reactive protein concentration after bone marrow transplantation for leukaemia. J Clin Pathol 1984; 37:263-66.
14. Van der Lelie, Von dem Borne et al. Platelet volume analysis for differential diagnosis of thrombocytosis. J Clin Pathol 1986; 39:129-133.
15. Zareifar S and Farahmand Far M. Changes in plateletcount and MPV during infections and inflammatory disease and their correlation with ESR and CRP. J Clin Lab Anal. 2014 may; 28(3) 245-248.
16. Schattner A, Kadi J, Dubin I. Reactive thrombocytosis in acute infectious disease. European journal of internal medicine Feb 19, 2019; volume 63, 42-45.
2. Vannucchi AM, Barbui T. Thrombocytosis and Thrombosis. Hematology Am Soc Hematol Educ Program.2007;363-70
3. Schafer AI. Thrombocytosis. N Engl J Med. 2004;350:1211-9
4. Levine SP. Thrombocytosis. Wintrobe’s Clinical Hematology A Waverly Company. 9thed, 1993;2:1648-55,1836-1923.
5. Nagai T, Komatsu N, Sakata Y, Miura Y, Ozawa K. Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. Intern Med 2005; 44: 1090-1092.
6. Baynes RD, Bothwell TH, Flax H et al - Reactive thrombocytosis in pulmonary tuberculosis. J Clin Pathol 1987; 40:676-679.
7. MC Donald TP. A comparison of platelet size, Platelet count 35s incorporation as assay for thrombopoietin. Br J Hematol 1978;38:257-67.
8. Omar M, Jogessar VR, Kamder MC. Thrombocytosis associated with tuberculosis peritonitis tubercle 1983; 64: 295-6.
9. Shaw AC. Serum C-reactive protein concentration in patient with viral or bacterial infection. J Clin Pathol. 1991; 44:546-599.
10. Peltola H, Holmberg C. Rapidity of C-reactive protein concentration in detecting potential septicaemia. Pediatr Infect Dis 1983; 2:374-6.
11. Mc Carthy PL, Frank AL, Ablow RC, Master SJ, Dolan TF Jr. C-reactive protein test in differentiation of bacterial and viral pneumonia. J Pediatr 1978; 92:454-6.
12. Rose PE, Johnson SA, Meakin M, Mackie PH, Stuart J. Serial study of C-reactive protein during infection in leukaemia. J Clin Pathol 1981; 34:263-6.
13. Rowe IF, Worsley AM, Donnelly P, Catvsky D, Goldman JM, Pepys HB. Measurement of serum C-reactive protein concentration after bone marrow transplantation for leukaemia. J Clin Pathol 1984; 37:263-66.
14. Van der Lelie, Von dem Borne et al. Platelet volume analysis for differential diagnosis of thrombocytosis. J Clin Pathol 1986; 39:129-133.
15. Zareifar S and Farahmand Far M. Changes in plateletcount and MPV during infections and inflammatory disease and their correlation with ESR and CRP. J Clin Lab Anal. 2014 may; 28(3) 245-248.
16. Schattner A, Kadi J, Dubin I. Reactive thrombocytosis in acute infectious disease. European journal of internal medicine Feb 19, 2019; volume 63, 42-45.
Published
2020-09-07
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