Histopathological Profile of Pediatric Solid Malignant Neoplasm in Tertiary Care Centre

  • Syeda Ayesha Government Medical College & Hospital Aurangabad -431003, Maharashtra, India.
  • Bharat R Sonwane Government Medical College & Hospital Aurangabad -431003, Maharashtra, India.
Keywords: Solid pediatric neoplasm, Nephroblastoma, Bone tumors, Retinoblastoma


Background: There is rise in incidence of pediatric tumors all over the globe. In developing country like India childhood morbidity & mortality is mainly due to malnutrition & infections but there is significant rise in incidence of pediatric neoplasm which is now becoming a distinct & important entity to be dealt upon. Objectives: To study the incidence of solid pediatric malignant neoplasms, the age and sex distribution in cases of solid pediatric malignant neoplasms and various histopathological appearance and patterns of solid pediatric malignant neoplasms. Methods: An observational study of solid pediatric malignant neoplasms in childhood was done over a period of 2 years, from November 2016 to October 2018 in the age group of 0-14 years. The institutional ethical committee Government Medical College & Hospital, Aurangabad- Maharashtra India has given approval for this study. Result: Total 180 cases of solid pediatric neoplasm were studied. The total sample received during study period was 180 out of which 55 were malignant. Out of 55 malignant tumors 30 were observed among males and 25 were observed among females. Most of the malignant tumors were observed among 11-14 yrs age group, followed by those observed among 0-3 years.   Conclusion: It can be concluded from our study that common solid malignancies in pediatric age group excluding hemato-lymphoid malignancies include nephroblastoma, retinoblastoma, neoplasms of gonads & bone tumors. Male predominance is a salient feature of childhood tumors. Most common solid tumors of childhood originate from embryonal tissue and tumors of epithelial origin are rare. A larger pediatric population based study would provide us with greater insight details about solid pediatric neoplasms.

Author Biographies

Syeda Ayesha, Government Medical College & Hospital Aurangabad -431003, Maharashtra, India.
Department of Pathology
Bharat R Sonwane, Government Medical College & Hospital Aurangabad -431003, Maharashtra, India.
Department of Pathology


1. Bhalodia JN, Patel MM. Profile of pediatric malignancy: A three year study. National journal of community medicine. 2011; 2(1).
2. Shah Sh1, Pervez S, Hassan Sh: Frequency of malignant solid tumours in children; J Pak Med Assoc. 2000 Mar; 50(3):86-8.
3. Vinod K P (ed), Arvind B (ed), O P Ghai: Ghai Textbook of essential pediatrics, 8th edition, CBS Publishers 2013, pg 599.
4. Bryan E. H, Kenneth F, Barbara N, Meenakshi S: Pediatric Solid Malignant Neoplasms : A comparative analysis;; Indian Journal of Pathology & Microbiology-54(3), 2011.
5. Knutti R E- Maliganat tumors of Childhood : California Medicine J 1952 Jan;76(1) :27.
6. Vandana G, Maruti D. The Spectrum of Malignant Solid Childhood Tumors in the age group of 0-12 years. Paediatr Neonatal Nurs Open J. 2015;2(3):85-90.
7. Sharma S, Mishra K, Agarwal S, Khanna G. Solid tumors of childhood. The Indian Journal of Pediatrics. 2004 Jun 1;71(6):501-4.
8. Raipal S P, Imeet M, Reetu K, Geetanjali J, Isha D & Harsh M-Spectrum of Non Hematological Pediatric Tumours: A clinico pathological study of 385 cases; Indian J Med Pediatric Oncol 2014 apr-june; 35(2): 170-174
9. Chandrashekhar T. N, Ravindra B. P, Geetalakshmi U, Ramesh B K- Solid Malignant Tumors of Infancy and Childhood: A Histopathological Study- Scholars Journal of Applied Medical Sciences, 2015;3(1C) 8b:167-174.
10. Gupta N, Choudhary M, Pachar S, Prakash Dhaka J, Verma R. Solid malignant pediatric tumors: a histopathological study. International Journal of Contemporary Pediatrics. 2017 Mar; 4(2):442.
11. Banerjee CK, Walia BN, Pathak IC. Pattern of neoplasms in children. The Indian Journal of Pediatrics. 1986 Jan 1;53(1):93-7.
12. Das S, Chakraborty AK, Mukherjee K, Kundu BK, Haldar KK. Profile of malignant lesions amongst children in North Bengal. Indian pediatrics. 1994 Oct;31:1281.
13. Yeole BB, Advani SH, Sunny L. Epidemiological features of childhood cancers in greater Mumbai. Indian pediatrics. 2001 Nov 1;38:1270-7.
14. Monga T, Kuka AS, Singh N. Histopathological Profile of Solid Tumours of Childhood and Infancy in Northwest Punjab, India. Indian Journal of Pathology and Oncology. 2017 Apr; 4(2):166-73.
15. Nnadi G.I, Egejuru R.O, Uchendu O. J. Childhood malignant tumours in owerri; a histopathological review. Int. J of Forensic Med Invest 2017; 2(2)19-24.
16. Srushti M, Balachandra B, Krutika S. Andola, Sainath K. A. Clinical, cytological and histopathological spectrum of pediatric lesions with emphasis on pediatric tumors. IP Archives of Cytology and Histopathology Research
2019; 4(3):265-276.
Original Article