A Rare Case Report of Invasive Ocular Surface Squamous Neoplasm of Conjunctiva

  • Noopur Subhash Patil MIMSR Medical College, Latur (MH) -India
  • Shivraj N Kanthikar MIMSR Medical College, Latur (MH) -India
  • Prashant B Chege MIMSR Medical College, Latur (MH) -India
  • Sheela N Kulkarni MIMSR Medical College, Latur (MH) -India
Keywords: Ocular surface neoplasia, HPV, Squamous cell carcinoma


Ocular surface neoplasm(OSSN) represent a rare but broad spectrum of disease, including mild dysplasia on one end of the spectrum and invasive Squamous cell carcinoma(SCC) on the other. Thus, the diagnosis completely depends on histopathological examination of the lesion. The incidence of ocular surface neoplasia is strongly associated with factors like solar ultraviolet radiation, HIV and human papilloma virus(HPV) infections. Most lesions occur at the limbus within the interpalpebral fissure particularly the nasal side. Their importance lies in the fact that they mimic benign lesions like pterygium or even chronic conjunctivitis and thus can be misinterpreted and inadequately treated. Red eye and ocular irritation are the most common presenting symptoms. No tumor related deaths or metastasis are generally seen. Surgery with intra-operative control of surgical margins and adjunctive chemotherapy, immunotherapy and cryotherapy result in good tumor control rates, with promising results in aggressive, recurrent and large tumors.

Author Biographies

Noopur Subhash Patil, MIMSR Medical College, Latur (MH) -India
Dept of Pathology
Shivraj N Kanthikar, MIMSR Medical College, Latur (MH) -India
Dept of Pathology
Prashant B Chege, MIMSR Medical College, Latur (MH) -India
Dept of Pathology
Sheela N Kulkarni, MIMSR Medical College, Latur (MH) -India
Dept of Pathology


1. Gichuhi S, Ohnuma S, Sagoo M, Burton M. Pathophysiology of ocular surface squamous neoplasia. Experimental Eye Research. 2014; 129:172-182
2. Patel S, Pokharel B, Shah A, Goda M, Thapa S. Clinico-Pathological Study of Ocular Surface Squamous Neoplasia in a Tertiary Care Centre of Western Region of Nepal. Journal of Universal College of Medical Sciences. 2019;7(1):9-13.
3. Asadi-Amoli F, Ghanadan A. Survey of 274 patients with conjunctival neoplastic lesions in Farabi Eye Hospital, Tehran 2006–2012. Journal of Current Ophthalmology. 2015;27(1-2):37-40.
4. Tunc M, Char D, Crawford B, Miller T. Intraepithelial and invasive squamous cell carcinoma of the conjunctiva: analysis of 60 cases. British Journal of Ophthalmology. 1999;83(1):98-103.
5. Viswamithra P, Bhaskara N. Ocular surface squamous neoplasia. Journal of Dr NTR University of Health Sciences. 2014;3(3):185.
6. Sethi H.S, Naik M, Joshi M, Gupta V S. Ocular surface squamous neoplasia (OSSN). DOS Times- Vol. 20, No. 6 December,2014:65-70.
7. Saegusa M, Takano Y, Hashimura M, Okayasu I, Shiga J. HPV type 16 in conjunctival and junctional papilloma, dysplasia, and squamous cell carcinoma. Journal of Clinical Pathology. 1995;48(12):1106-1110.
8. Mittal R, Rath S, Vemuganti G. Ocular surface squamous neoplasia – Review of etio-pathogenesis and an update on clinico-pathological diagnosis. Saudi Journal of Ophthalmology. 2013;27(3)
9. Guech-Ongey M, Engels E, Goedert J, Biggar R, Mbulaiteye S. Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United States. International Journal of Cancer. 2008;122(11):2590-2593.
10. Templeton A. Tumors of the eye and adnexa in Africans of Uganda. Cancer. 1967;20(10):1689-1698.
Case Report