Metastatic Breast Carcinoma to The Uterine Cervix - An Unusual Presentation

  • Maymol P Varghese Amala Institute of Medical Sciences, Thrissur
  • Sreeja Raju Amala Institute of Medical Sciences, Thrissur
  • Savithri MC Amala Institute of Medical Sciences, Thrissur
  • Joy Augustine Amala Institute of Medical Sciences, Thrissur
  • Mathew Varghese Amala Institute of Medical Sciences, Thrissur
Keywords: Lobular Carcinoma, Uterine Cervix, E-cadherin

Abstract

Uterine cervix involvement as a site of metastasis from a distant primary tumor is rare. Metastasis from breast carcinoma in a patient undergoing treatment is even rarer.  The present case report is of a 47-year-old lady with history of carcinoma breast on treatment and who was referred to our hospital with complaints of lower limb oedema, low backache and postmenopausal whitish discharge per vaginum. Per vaginal examination revealed a lesion arising in the cervix extending up to the anterior vaginal wall suggestive of a clinical diagnosis of carcinoma cervix. Subsequent biopsy from the lesion showed malignant cells arranged in Indian file pattern and focal alveolar pattern, hinting at a diagnosis of Invasive lobular carcinoma metastasis.  The neoplasm was positive for ER, PR and GATA-3 and negative for Her2/neu and E-cadherin confirming our diagnosis. Although rare, the poor outcome in such patients makes it even more important for its identification and the need for them to undergo careful routine gynecologic examination.

References

Pérez-Montiel D et al; Adenocarcinoma metastatic to the uterine cervix: a case series J Obstet Gynaecol Res.2012 ;38(3) 541–9

Cao AY et al; Tumor characteristics and the clinical outcome of invasive lobular carcinoma compared to infiltrating ductal carcinoma in a Chinese Population World J Surg Oncol 2012

Engelstaedter V and Mylonas I ; Lower genital tract metastases at time of first diagnosis of mammary invasive lobular carcinoma ;Arch Gynecol Obstet 2011;283(1) 93–5

Rajitha L et al;Metastatic lobular carcinoma of breast mimics primary cervix carcinoma: two case reports and a review of the literature. ecancer 2015;9:571

De Leeuw WJ, Berx G et al: Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situ: J Pathol (1997);183:404–411.

Published
2021-02-28
Section
Case Report