Impact of Haemodialysis on Coagulation Profile in Chronic Kidney Disease

  • Veena Raja Department of Pathology, SRM Medical College Hospital and Research Centre, SRM IST, Potheri, Chengalpattu - 603203
  • Shivashekar Ganapathy Department of Pathology, SRM Medical College Hospital and Research Centre, SRM IST, Potheri, Chengalpattu - 603203
  • Suresh Kumar Karthikean Department of Forensic Medicine, ACS Medical College and Hospital Chennai - 600077
  • Pradhiksha Das Prakash
Keywords: Chronic kidney disease, Coagulation Profile, Hemodialysis, Bleeding disorders, thrombocytopenia


Background Chronic kidney disease (CKD) with its high prevalence, morbidity and mortality is an important public health problem. Considering the nature of the haemodialysis process, it has a considerable impact on the coagulation profile. To find out the variations in Platelet count, Prothrombin time (PT), International Normalised Ratio (INR) and Activated Partial Thromboplastin Time (aPTT) before and after haemodialysis patients. Materials and Methods: This prospective observational study of Coagulation profile and platelet count in pre and post hemodialysis patients with chronic renal failure was conducted on 150 CKD patients in the Department of Pathology, SRM Medical College Hospital & Research Centre. p value <0.05 was considered to be statistically significant. Results In this study, there was significant reduction in platelet count from mean 2.29 cells/ in pre dialysis to 2.03 cell/ in post dialysis. There was a significant prolongation in both PT and aPTT values in post dialysis Conclusion These findings expose CKD patients to higher risk of bleeding disorders, which may have a role in increasing the rate of patient mortality and morbidity. In the light of this study, there is a need for nephrologist to monitor the coagulation profile and platelet count of CKD patients on dialysis, and treat any derangements in the same, so as to improve outcome for these patients.


Habib A, Ahmad R, Rehman S. Hematological changes in patients of chronic renal failure and the effect of hemodialysis on these parameters. Int J Res Med Sci. 2017;5(11):4998–5003

Pahim H, Megalamane S. Platelet Indices and Basic Coagulation Profile of Type 2 Diabetic Patients undergoing Haemodialysis in Rural Population. J Clin Diagnostic Res. 2017;11(10):9–12

Gautam R, Patil PM. Hematological Changes in Pre and Post Hemodialysis in Patients With Chronic Renal Failure. J Evid Based Med Health. 2018;5(25):1914–9

Hakim YAH, Abbas AA, Khalil A, Hameeda T, Mustafa IA. The Effect of Hemodialysis on Hemoglobin Concentration, Platelets count and White Blood Cells Count in End Stage Renal Failure. Int J Med Res Heal Sci. 2016;5(5):22–35

Jalal DI, Chonchol M, Targher G. Disorders of hemostasis associated with chronic kidney disease. Semin Thromb Hemost. 2010;36(1):34–40

Chakravarti A, Ukey A, Bajaj P, Saragade P. A Study of Hematological Profile in Patients of Chronic Renal Failure Undergoing Hemodialysis at a Tertiary Health Care Institute. MVP J Med Sci. 2017;4:107–12

Kovesdy CP, Alrifai A, Gosmanova EO, Lu JL, Canada RB, Wall BM, et al. Age and outcomes associated with BP in patients with incident CKD. Clin J Am Soc Nephrol. 2016;11(5):821–31

Pandian J, Amitkumar K, Swaminathan A. Assessment of impact of hemodialysis on hematological parameters among patients with chronic kidney disease. Comp Clin Path. 2017;26(1):213–8

Daugirdas JT, Bernardo AA. Hemodialysis effect on platelet count and function and hemodialysis-associated thrombocytopenia. Kidney Int. 2012;82(2):147–57

Matsuo T, Wanaka K. Heparin-Induced Thrombocytopenia and Hemodialysis. J Blood Disord Transfus. 2011, S2

Abdullah Khader Alghythan and Abbas H. Alsaeed. Hematological changes before and after hemodialysis. Sci Res Essays. 2012;7(4):490–7

Khan MZ, Akhtar SZ, Pervez SN, Khan MS, Malik A. Coagulation profile in pre and post hemodialysis. Int J Applied Res. 2015;7(1):33–6

Khalid A, Zafar L. Effect of Haemodialysis on Mean Prothrombin Time and Activated Partial Thromboplastin Time in Patients of End Stage Renal Disease. J Rawalpindi Med Col. 2015;19(3):247–9.

Mandi SP, Ghosh K, Chakraborty S, Pal M, Koley S, Comparative study of standard coagulation profile in non-dialyzed and post-dialyzed patients suffering from chronic kidney disease. Journal of Drug Delivery & Therapeutics. 2016;6(3):78-83

Original Article