Histopathological Spectrum of Adult and Paediatric Meningiomas

  • Ishita Pant Department of Pathology, Institute of Human Behaviour and Allied Sciences, Delhi, India
  • Sujata Chaturvedi Department of Pathology, Institute of Human Behaviour and Allied Sciences, Delhi, India
  • Pragyan Sarma Department of Neurosurgery, GTB Hospital, University College of Medical Sciences, Delhi, India
  • Shelly Sehgal Department of Pathology, Swami Dayanand (SDN) Hospital, Delhi, India
Keywords: Adult meningiomas, Paediatric meningiomas, Histopathology, Spectrum of meningiomas


Introduction: Meningiomas are a group of neoplasms showing a spectrum of histopathological variants, mostly corresponding to World Health Organization (WHO) grade I. However, certain histologic variants correspond histologically to WHO grades II and III. In this study, the histopathological spectrum of the adult as well as paediatric meningiomas received in our department over the last 12 years is being revisited with the aim to analyse the various histopathological variants, to assess their grade as per WHO 2016 criteria, their epidemiology and localization. Material and methods: A retrospective analysis of the histopathology records and clinical case files was done in 336 cases of (adult and paediatric meningiomas) histopathologically diagnosed cases of intracranial and intraspinal meningiomas (WHO grade I, II and III) received over a period of 12 years (starting from 2009-2020) in our department. Results: The commonest grade in adults and children was WHO Grade I while the commonest histopathological variant in adults and children was Transitional meningioma.  Conclusion: As per WHO classification of CNS Tumours 2016, grade I meningiomas are associated with low risk of recurrence and aggressive behaviour, while WHO grade II and III meningiomas are associated with greater likelihood of recurrence and aggressive behaviour, highlighting the importance of accurate typing and grading of meningiomas on histopathology. 


Okonkwo DO, Laws ER. Meningiomas: Historical perspective. In JH Lee (Ed.) Meningiomas: Diagnosis, Treatment, and Outcome London: Springer 2009: 3-10

Cushing H, Eisenshardt L. Meningiomas: Their classification, Regional behaviour,

Life history and Surgical end results. Springfield, IL: CC Thomas; 1938

Kepes J. Meningiomas: Biology, Pathology and Differential Diagnosis. New York: Masson; 1982: 44-47

Perry A, Louis DN, Scheithauer BW. Meningiomas. In Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, WHO Classification of Tumours of the Central Nervous System , Lyon; IARC 2007: 164-172

Perry A, Louis DN, Budka H, von Deimling A, Rushing EJ, Mawrin C, Clause EB, Loeffler J, sadetzki S. Meningioma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK,WHO Classification of Tumours of the Central Nervous System , Lyon; IARC 2016: 232-245

Dolecek TA, Propp JM, Stroup NE, Kruchko C. CBTRUS statistical report: primary brain and central nervous system tumours diagnosed in the United States in 2005-2009. Neuro Oncol 2012; 14: 1-49

Louis DN, Ohgaki H, Otmar DW, Cavenee WK, Burger PC, Jouvet A. The 2007 WHO classification of tumors of the central nervous system. Acta Neuropathol 2007;114: 97-109

Germano IM, Edwards MS, Davis RL, Schiffer D. Intracranial meningiomas of the first two decades of life J Neurosurg 1994; 80: 447-453

Shah SR, Gonsai N, Makwana R. Histopathological study of meningioma in civil hospital, Ahmedabad. International Journal of Current Research and Review. 2013;5:76-82

Shrilakshmi S. Meningiomas:a clinicopathological study. Int J Med Res Health Sci. 2015;4: 827-831

Patty IS. Central Nervous System Tumours- A Clinicopathological study. J Dohuk Univ 2008; 11: 173-180

Fan MC, Fang KL, Wang C, Deng WS, Sun P, Tang WZ. Paediatric intracranial meningiomas: eightyear experience with 32 cases. Chinese Neurosurgical Journal 2017; 3: 21

Jaiswal S, Vij M, Mehrotra A, Jaiswal AK, Srivastava AK, Behari S. A clinicopthological and neuroradiological study of paediatric meningioma from a single centre. J Clin Neurosci. 2011;18: 1084–1089

Menon G, Nair S, Sudhir J, Rao BR, Mathew A, Bahuleyan B. Childhood and adolescent meningiomas: a report of 38 cases and review of literature. Acta Neurochir 2009;151: 239–244

Im SH, Wang KC, Kim SK, Oh CW, Kim DG, Hong SK. Childhood meningioma: unusual location, atypical radiological findings, and favourable treatment outcome. Childs Nerv Syst. 2001;17: 656–662

Greene S, Nair N, Ojemann JG, et al. Meningiomas in children. Pediatr Neurosurg.


Thomas BG, Moen BH, Torp SH. The histopathological spectrum of human meningiomas. Int J Clin Exp Pathol 2012;5:231-242.

Wiemels J, Wrensch M, Claus EB. Epidemiology and etiology of meningioma. J Neuro oncol 2010; 99: 307-314

Mubeen B,Makhdoomi R, Nayil K, et al. Clinicopathological characteristics of meningiomas: Experience from a tertiary care hospital in the Kashmir Valley. Asian J Neurosurg2019; 14:41-46

Engelhard HH. Progress in the diagnosis and treatment of meningiomas. Diagnostic imaging, preoperative embolization. SurgNeurol 2001; 155: 89-101

Zhang H, Rodiger LA, Shen T. Perfusion MR imaging for differentiation of benign and malignant meningiomas. Neuroradiology 2008; 50: 525-530

Khursheed N, Rumana M, Ramzan A, Abrar W. En-plaque spinal meningioma: A rare entity. Neurosurg 2013; 23: 61-63

Thuijs NB, Bernard MJ, Uitdehaag WJR, Van O, Paul van der V, Vandertop WP, Saskia. Pediatric meningiomas in The Netherlands 1974–2010: a descriptive epidemiological case study. Childs Nerv Syst 2012; 28: 1009-1015

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