Concurrent Benign Brenner Tumor and Mucinous Cystadenoma of an Ovary in a Postmenopausal Woman: A Case Report

  • Samrita Samaddar Department of Pathology, V.N. Desai Municipal General Hospital, Santacruz East, Mumbai, Maharashtra, India
  • Abhijit Gajendra Bhanji Department of Pathology, V.N. Desai Municipal General Hospital, Santacruz East, Mumbai, Maharashtra, India
  • Vivek Sreekumaran Nair Department of Pathology, V.N. Desai Municipal General Hospital, Santacruz East, Mumbai, Maharashtra, India
Keywords: Mucinous cystadenoma, Brenner tumor, epithelial tumor, ovarian tumors


Ovarian cancer is the most fatal gynecologic malignancy. The surface epithelial tumor is the most common type of ovarian cancer. Among these, mucinous tumors account for 10-15% of ovarian tumors. Surgical pathologists find that mucinous ovarian tumors are among the most challenging ovarian neoplasms to interpret. Sometimes, other types of surface epithelial cancers coexist with mucinous tumors. Because of this, it's critical to diagnose mucinous tumors accurately. On the other hand, the association of Brenner tumors with other neoplasms is rare. Ovarian Brenner tumor has always been discussed by pathologists as an enigmatic tumor because of its rarity and disputed histogenesis. Here, we report a rare case of mucinous cystadenoma of the ovary with a Brenner component in a 68-year-old postmenopausal woman.


Alan HD, Lauren N, Neri L, Ashley SR. Current Diagnosis and Treatment Obstetrics and Gynecology. McGraw Hill; 2013. p. 848–9.

Berek JS. Berek & Novak’s gynecology essentials. Baltimore, MD: Wolters Kluwer Health; 2020.

Chen VW, Ruiz B, Killeen JL, Cote TR, Wu XC, Correa CN. Pathology and classification of ovarian tumors. Cancer. 2003;97.

Hemalatha AL, Konanahalli P. Bilateral malignant Brenner tumor of ovary. J Obstet Gynecol India. 2005;55:81–2.

Sridevi S, Rao V, Kumar S, Bhagyalakshmi A. Mucinous cystadenoma with Brenner tumor: A Case Report. J Evid Based Med Healthc. 2015;2(4):455–8.

Zaloudek CJ, Garg K. Diagnostic histopathology of tumors. 4th ed. Fletcher CDM, editor. China: Saunders; 2013.

Juan R. Rosai and Ackerman’s Surgical Pathology. 2017. p. 1374–90.

Kato H, Kanematsu M, Furui T, Morishige K, Hirose Y. Ovarian mucinous cystadenoma coexisting with benign brenner tumor: MR imaging findings. Abdom Imaging. 2013;38:412–6.

Jung SE, Lee JM, Rha SE, Byun JY, Jung JI, Hahn ST. CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. Radiographics. 2002;22:1305–25.

Green GE, Mortele KJ, Glickman JN, Benson CB. Brenner tumors of the ovary: sonographic and computed tomographic imaging features. J Ultrasound Med. 2006;25:1245–51.

Ioffe OB, Simsir A, Silverberg SG. Pathology. In: Js PGO, Hacker NF, editors. Practical Gynaecologic Oncology. Lippincott Williams & Wilkins Company; 2000. p. 213–4.

Waxman M. Pure and mixed Brenner tumor of the ovary: clinicopathologic and histogenetic observations. Cancer. 1979;43:1830–9.

Philip B, Clement RH. Ovarian Surface Epithelial-Stromal Tumors. NY: Raven Press; 2009.

Pradhan P, Mohanty L, Pradhan D, Pujari S, Kar A. Benign brenner tumor of ovary with mucinous cystadenoma: a case report. Asia J Pharm Health Sci. 2017;7:1643–6.

Nazari F, Dehghani Z. Coexistence of benign brenner tumor with mucinous cystadenoma in an ovarian mass. Iran J Pathol. 2020;15(4):334–7.

Case Report