Study of relationship between Platelet Volume Indices and Hyperlipidemia
Keywords:
Platelet Volume Indices, Platelet, Hyperlipidemia, MPV
Abstract
Background: Mean platelet volume (MPV) correlates well with platelet activity as larger platelets tend to be metabolically and enzymatically more active than smaller platelets and secrete more prothrombotic factors. Studies have shown that there is a constant association of increased MPV with atherosclerotic diseases like coronary ischemic disease, myocardial infarction and cerebral infarct as well as with diabetes and hypertension. Hyperlipidemia, being a closely associated condition, is also expected to show changes in platelet size. We try to study the relationship between platelet volume indices and hyperlipidemia.Methods: 100 patients with deranged lipid profile on recent lab biochemical lab reports in OPD and indoor ward patients of Sassoon general hospital, Pune have been studied. Included cases have been segregated as separate groups for patients with deranged lipid profile along with atherosclerotic disease, diabetes or hypertension. The platelet parameters like platelet count and the platelet volume indices (PVI), including mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P‐LCR); were compared with 30 age matched controls.Results: Mean MPV (9.79 ±1.01), PDW (13.18 ± 2.44) and P-LCR (24.85 ± 7.14) of cases were significantly higher than the controls (mean MPV = 9.22 ± 0.91, mean PDW= 11.64 ± 1.75, mean P-LCR= 20.70 ± 7.07; p-value < 0.05). Also, hyperlipidemic patients having an associated disease had significantly higher PVI than the patients having hyperlipidemia in isolation.Conclusion: The estimation of these indices can be considered as an early, economical and rapid procedure for identification of complications in hyperlipidemic patients.References
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9. Martin JF. Bath PM, Burr ML. Influence of platelet size on outcome after myocardial infarc-tion. Lancet 1991;338:1409-11.
10. D’Erasmo E, Aliberti G, Celi FS, Romagnoli E, Vecci E, Mazzuoli GF. Platelet count, mean platelet volume and their relation to prognosis in cerebral infarction. J Intern Med 1990;227:11-4.
11. Sharpe PC, Trinick T. Mean platelet volume in diabetes mellitus. Q J Med 1993;86:739-42.
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14. Ranjith MP, Divya R, Mehta VK, Krishnan MG, Kamalraj R, Kavishkar A. Significance of platelet volume indices and platelet count in ischemic heart disease. J Clin Pathol 2009;62:830-3.
15. Jindal S, Gupta S, Gupta R, Kakkar A, Singh HV, Gupta K et al. Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology 2011;16:86-9.
16. Grotto HZ, Noronha JF. Platelet large cell ratio (P-LCR) in patients with dyslipidemia. Clin Lab Haematol 2004;26:347-9.
17. Bain BJ. Platelet count and platelet size in males and females. Scand J Haematol 1985;35:77-9.
18. Toryila JE, Amadi K, Adelaiye AB. Platelet count and mean platelet volume amongst elderly Nigerians. Science World J 2009;4:15-8.
19. Dogru T, Tasci I, Naharci MI, Sonmez A, Erdem G, Kilic S, et al. Mean platelet volume levels in metabolic syndrome. AJCI 2007;1:99-105.
20. Pathansali R, Smith N, Bath P. Altered megakaryocyte-platelet haemostatic axis in hypercholesterolaemia. Platelets 2001;12:292-7.
21. Ravindran R, Krishnan LK. Incresased platelet cholesterol and decreased percentagre volume of platelets as a secondary risk factor for coronary artery disease. Pathophysiol Haemost Thromb 2007;36:45-51.
22. Fuchs J, Beigel Y, Green P, Zlotikamien B, Davidson E, Rotenberg Z, et al. Big platelets in hyperlipidemia patients. J Clin Pharmacol 1992; 32:639-42.
23. Pizzulli L, Yang A, Martin JF, Luderitz B. Changes in platelet size and count in unstable angina compared to stable angina or non-cardiac chest pain. Eur Heart J 1998;19:80-4.
2. Lacoste L, Lam JY, Hung J, Letchacovski G, Solymoss CB, Waters D. Hyperlipidemia and coronary disease. Correction of the increased thrombogenic potential with cholesterol reduction. Circulation 1995;92:3172-7.
3. Saluja JG, Ajinkya MS, Khemani B. Comparative study of serum lipids and fibrinogen levels in diabetes mellitus and its clinical significance in Indian population. Bombay Hospital Journal 2000;42:466-70.
4. Castelli WP, Anderson K. A population at risk: prevalence of high cholesterol levels in hypertensive patients in the Framingham study. Am J Med 1986;80(2 suppl1):23-32.
5. Ames RP. Hyperlipidemia in hypertension: causes and prevention. Am Heart J 1991;122:1219-24.
6. Corash L, Tan H, Gralnick HR. Heterogeneity of human whole blood platelet subpopulations. I. Relationship between buoyant density, cell volume and ultrastructure. Blood 1977;49:71-87.
7. Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res.1983; 32:443-60.
8. Khandekar MM, Khurana AS, Deshmukh SD, Kakrani AL, Katdare AD, Inamdar AK. Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J Clin Pathol 2006;59:146-9.
9. Martin JF. Bath PM, Burr ML. Influence of platelet size on outcome after myocardial infarc-tion. Lancet 1991;338:1409-11.
10. D’Erasmo E, Aliberti G, Celi FS, Romagnoli E, Vecci E, Mazzuoli GF. Platelet count, mean platelet volume and their relation to prognosis in cerebral infarction. J Intern Med 1990;227:11-4.
11. Sharpe PC, Trinick T. Mean platelet volume in diabetes mellitus. Q J Med 1993;86:739-42.
12. Hilbert T, Lifshitz MS. Lipids and Dyslipo-proteinemia in Henry JB. Clinical diagnosis and management by laboratory methods. 21st ed. New York: W.B. Saunders co.2009.p.200-230.
13. Thompson CB, Diaz DD, Quinn PG, Lapins M, Kurtz SR, Valeri CR. The role of anticoagulation in the measurement of platelet volumes. Am J Clin Pathol 1983;80:327-32.
14. Ranjith MP, Divya R, Mehta VK, Krishnan MG, Kamalraj R, Kavishkar A. Significance of platelet volume indices and platelet count in ischemic heart disease. J Clin Pathol 2009;62:830-3.
15. Jindal S, Gupta S, Gupta R, Kakkar A, Singh HV, Gupta K et al. Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology 2011;16:86-9.
16. Grotto HZ, Noronha JF. Platelet large cell ratio (P-LCR) in patients with dyslipidemia. Clin Lab Haematol 2004;26:347-9.
17. Bain BJ. Platelet count and platelet size in males and females. Scand J Haematol 1985;35:77-9.
18. Toryila JE, Amadi K, Adelaiye AB. Platelet count and mean platelet volume amongst elderly Nigerians. Science World J 2009;4:15-8.
19. Dogru T, Tasci I, Naharci MI, Sonmez A, Erdem G, Kilic S, et al. Mean platelet volume levels in metabolic syndrome. AJCI 2007;1:99-105.
20. Pathansali R, Smith N, Bath P. Altered megakaryocyte-platelet haemostatic axis in hypercholesterolaemia. Platelets 2001;12:292-7.
21. Ravindran R, Krishnan LK. Incresased platelet cholesterol and decreased percentagre volume of platelets as a secondary risk factor for coronary artery disease. Pathophysiol Haemost Thromb 2007;36:45-51.
22. Fuchs J, Beigel Y, Green P, Zlotikamien B, Davidson E, Rotenberg Z, et al. Big platelets in hyperlipidemia patients. J Clin Pharmacol 1992; 32:639-42.
23. Pizzulli L, Yang A, Martin JF, Luderitz B. Changes in platelet size and count in unstable angina compared to stable angina or non-cardiac chest pain. Eur Heart J 1998;19:80-4.
Published
2014-07-20
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