Extra-oral verruciform xanthoma: an uncommon entity
Keywords:
Verruciform xanthoma, Papilloma, Foamy macrophages, Papillary dermis,
Abstract
Verruciform xanthoma (VX) is an uncommon benign condition, which frequently affects the oral mucosa in adults. Only few cases of VX of anogenital region and skin have been reported. Clinically, it presents as a white or yellowish-white sessile or pedunculated, papillary or verrucous mucosal growth and is usually less than 2 cm in size. Although it is considered a benign entity, it has clinical importance as it needs to be differentiated with wart like growths i.e. verrucous carcinoma, condyloma acuminatum, seborrheic keratosis and due to its strong association with more serious diseases like epidermolysis bullosa, epithelial dysplasia, pemphigus vulgaris, solar keratosis and discoid lupus erythematosus. The etiology of this lesion is unknown, however is thought to be reactive rather than a neoplastic process secondary to epithelial damage induced by different associated conditions. We present two cases of VX and discuss their clinical and histopathological findings and possible correlation with a postulated etiopathogenesis.References
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2. Mohsin SK, Lee MW, Amin MB, et al. Cutaneous verruciform xanthoma: a report of five cases investi-gating the etiology and nature of xanthomatous cells. The American Journal of Surgical Pathology.1998; 22:479-87.
3. Shafer WG. Verruciform xanthoma. Oral Surg. 1971;31:784-9
4. Zegarelli DJ, Zegarelli-Schmidt EG, Zegarelli EV. Verruciform xanthoma: further light and electron mi-croscopic studies, with the addition of a third case. Oral Surg. 1975; 40: 246–56.
5. Kanitakis J, Euvrard S, Butnaru AC, Claudy A. Verru-ciform xanthoma of the scrotum in a renal transplant patient. British Journal of Dermatology 2004; 150:155-77.
6. Sibaud V, Marit G, Deminiere C, et al. Multiple verru-ciform xanthomas of the oral mucosa associated with graft versus host disease. Ann Dermatol Venereol. 2006; 133:995-9.
Published
2014-01-28
Issue
Section
Case Report
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