A cytopathological study of malignant thyroid lesions and its implications in a referral center.

  • Shifa Syed Ibrahim Assistant Professor,Department of Pathology,Madurai Medical College,Madurai
  • Sharnila Thilagavathy Narayanan Madurai Medical College, Madurai.
  • Meenakumari Gopalakrishnan Madurai Medical College, Madurai.
Keywords: Papillary, Insular, Anaplastic, Medullary.


Background: Fine needle aspiration [FNA] is the well-established diagnostic modality. It has a positive predictive value of 99% in diagnosing malignant thyroid lesions. The incidence of various thyroid malignancies in our department was evaluated using FNA and they were compared to those available in the literature.Methods: During our study period, cases those were referred to our lab for FNAC thyroid were retrieved from the records. From that, malignant cases reported during our study period were enumerated and reexamined. The prevalence of malignant cases, its age and sex incidence was calculated. Increase in the incidence of undifferentiated thyroid carcinoma cases in our setup was recognized and our experience was compared with those available in the literatures.Result: During our study period, 339 thyroid cases were reported. The incidence of papillary carcinoma was 26.3% and anaplastic carcinoma was 58% in our study. Peak age incidence was around 50-60 years. Female predominance was noted in all age groups except in the 50-60 year category where male predominated. When the tumor was staged based TNM classification, anaplastic carcinoma presented with a higher stage.Conclusion: Thyroid FNAC has a high predictive value in the diagnosis of malignancies. The incidence of undifferentiated carcinoma was higher in our setup. The reason for the increase in the incidence needs further evaluation. DOI: 10.21276/APALM.1063 

Author Biographies

Shifa Syed Ibrahim, Assistant Professor,Department of Pathology,Madurai Medical College,Madurai
Assistant Professor, Department of Pathology
Sharnila Thilagavathy Narayanan, Madurai Medical College, Madurai.
Professor, Department of Pathology
Meenakumari Gopalakrishnan, Madurai Medical College, Madurai.
Professor,Department of Pathology


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Original Article