Mucinous Adenocarcinoma Of Colon Presenting As Cutaneous Metastases Over The Abdominal Wall: A Rare Entity On Cytology
Keywords:
Mucinous Adenocarcinoma, Cutaneous Metastases, Colon
Abstract
Skin metastases from colorectal carcinoma are rare and typically signify widespread disease with poor prognosis. We present two cases of a 55years old man and a 57 years old lady, both presenting with multiple skin nodules on the abdominal wall. FNAC smears of both the cases showed clusters and sheets of atypical cells with moderate amount of cytoplasm against a necrotic background. Nuclei were round to oval with coarse chromatin and prominent nucleoli. Well formed glandular structures were seen. Immunocytochemistry showed that cells were positive for Muc-1, and negative for vimentin and LCA. A diagnosis of adenocarcinoma presenting as cutaneous metastasis was given. Detailed history, showed that both the patients were known cases of adenocarcinoma colon post chemotherapy and radiotherapy. Colorectal carcinoma presenting as cutaneous metastases is rare and FNAC is a noninvasive and fast method for directing towards the diagnosis of cutaneous metastasis in the patients with a known malignancy without any complication. DOI: 10.21276/APALM.2017.1070References
1. Krathen RA, Orengo IF, Rosen T. Cutaneous metastasis: a meta-analysis of data. South Med J. 2003; 96:164-7.
2. Pereira WA, Humaire CR, Silva CS, Fernandes LH. Sister Mary Joseph's nodule: a sign of internal malignancy. An Bras Dermatol. 2011;86:S118–S120.
3. Helm TN, Lee TC. Metastatic carcinoma of the skin: treatment & medication [serial on the Internet] 2010 [cited 2010 Dez 18]. Available from: URL: http://emedicine.medscape.com/Article/1101058-Treatment.
4. Verardino GC, Silva RS, Obadia DL, Gripp AC, Alves Mde F. Rare cutaneous metastasis from a probable basaloid carcinoma of the colon mimicking pyogenic granuloma. An Bras Dermatol. 2011;86:537–540.
5. Krathen RA, Orengo IF, Rosen T. Cutaneous metastasis: A meta-analysis of data. South Med J. 2003;96:164–166.
6. Lo Russo G, Accarpio F, Spinelli G, Miele E, Borrini F, Cerbone L et al. Subcutaneous metastases from colon cancer: a case report. Journal of Medical Case Reports. 2012; 6:212
7. Gu Y, Tang R, Gong DQ, Qian YL. Reconstruction of the abdominal wall by using a combination of the human acellular dermal matrix implant and an interpositional omentum flap after extensive tumor resection in patients with abdominal wall neoplasm: a preliminary result. World J Gastroenterol. 2008;14:752–757.
2. Pereira WA, Humaire CR, Silva CS, Fernandes LH. Sister Mary Joseph's nodule: a sign of internal malignancy. An Bras Dermatol. 2011;86:S118–S120.
3. Helm TN, Lee TC. Metastatic carcinoma of the skin: treatment & medication [serial on the Internet] 2010 [cited 2010 Dez 18]. Available from: URL: http://emedicine.medscape.com/Article/1101058-Treatment.
4. Verardino GC, Silva RS, Obadia DL, Gripp AC, Alves Mde F. Rare cutaneous metastasis from a probable basaloid carcinoma of the colon mimicking pyogenic granuloma. An Bras Dermatol. 2011;86:537–540.
5. Krathen RA, Orengo IF, Rosen T. Cutaneous metastasis: A meta-analysis of data. South Med J. 2003;96:164–166.
6. Lo Russo G, Accarpio F, Spinelli G, Miele E, Borrini F, Cerbone L et al. Subcutaneous metastases from colon cancer: a case report. Journal of Medical Case Reports. 2012; 6:212
7. Gu Y, Tang R, Gong DQ, Qian YL. Reconstruction of the abdominal wall by using a combination of the human acellular dermal matrix implant and an interpositional omentum flap after extensive tumor resection in patients with abdominal wall neoplasm: a preliminary result. World J Gastroenterol. 2008;14:752–757.
Published
2017-02-19
Issue
Section
Case Report
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
