Immunohistochemical Expression of IGF-1R In cutaneous and Mucocutaneous Sqamous Cell Carcinoma

  • Muhammad Abdelrahman Abdelfattah Muhammad Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
  • Doaa Abdallah Shaban Department of Pathology, Faculty of Medicine, Port said University, port said, Egypt
  • Azza H. M. Zidan Lecturer of pathology, faculty of medicine, Suez Canal university, Ismailia, Egypt
  • Mohamed O El-Okda Lecturer of pathology, faculty of medicine, Suez Canal university, Ismailia, Egypt
Keywords: squamous cell carcinoma, insulin-like growth factor-1 receptor, immunohistochemistry, cancer, tyrosine kinase.


Background: IGF-1R is a transmembrane receptor belongs to class of tyrosine kinase receptors, found in many tumors and is often associated with an aggressive phenotype. IGF-1R is important for regulation of growth, differentiation and apoptosis, as such, could be a pre¬ferred target for therapeutic interventions. Aim:Investigate the expression pattern of IGF-1R in different histological grades of cutaneous and mucocutaneous squamous cell carcinoma and correlate with clinicopathological prognostic factors. Materials: Forty-eight specimens of cSCC were stained immunohistochemically with IGF-1R monoclonal antibody and correlated with different clinicopathologic factors. Results: All tumors showed a degree of positivity of IGF-1R cytoplasmic and membranous expression, however; with variable degrees. High grade tumors had significantly higher IGF-1R expression than low grade tumors. IGF-1R expression showed a strong positive correlation with the tumor grade (P<0.001). Also, IGF-1R expression showed a significant relation with the depth of invasion of SCC (P<0.001). Conclusion: IGF-1R expression is significantly associated with high grade in cutaneous and mucocutaneous squamous cell carcinoma and also associated with tumors showing deeper invasion; therefore, IGF-1R may have a role pathogenesis and progression of cutaneous and mucocutaneous squamous cell carcinoma.


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Original Article