Seroprevalence of Hepatitis E IgG antibodies among Voluntary Blood Donors in a tertiary hospital

  • Chinnadurai Peermohd Luck Associate Professor, Department of Pathology,Tagore medical college and hospital, Chennai, Tamilnadu, India
  • Srirangramasamy Jamuna Rani Associate Professor, Department of Pathology,Tagore medical college and hospital, Chennai, Tamilnadu, India
  • Duraipandian Jeyakumari Professor, Department of Microbiology, Tagore Medical college and Hospital, Rathinamangalam, Chennai-600127, Tamilnadu, India
  • Madasamy Balamurugan Professor and HOD, Department of Pathology, Tagore Medical college and Hospital, Rathinamangalam, Chennai-600127, Tamilnadu, India
  • Aruna V Padmavathi Assistant Professor, Department of Pathology, Tagore Medical college and Hospital, Rathinamangalam, Chennai-600127, Tamilnadu, India
  • Kolsamma Nasrin Assistant Professor, Department of Pathology, Tagore Medical college and Hospital, Rathinamangalam, Chennai-600127, Tamilnadu, India
Keywords: Hepatitis E, parenteral transmission, blood transfusion, maternal mortality, HEV IgG

Abstract

Background: Transfusion safety is a major concern in medical practice. Hepatitis E is a potential threat among transfusion-transmitted infections. In resource poor settings and in endemic countries, parenteral transmission can occur at an increased rate and leads to subclinical infection. Currently Hepatitis E virus screening is not mandatory in many countries. This can possibly endanger the population.Methods: We aimed at estimating the seroprevalence of HEV antibodies (IgG) among healthy blood donors in Chennai, South India. A prospective study was conducted among 142 blood donors from January 2016 to November 2016 in a tertiary care teaching hospital. Serum anti HEV IgG antibody was detected by Enzyme Linked Immuno Sorbent Assay (ELISA).Results: Out of 142 samples, 19/142 (13.38%) showed positivity for IgG antibodies for HEV.Conclusion: This study showed the importance of screening for HEV, as there is increased rate of positivity among the blood donors in our study population.  DOI: 10.21276/APALM.1370

Author Biographies

Chinnadurai Peermohd Luck, Associate Professor, Department of Pathology,Tagore medical college and hospital, Chennai, Tamilnadu, India
Associate Professor Pathology
Srirangramasamy Jamuna Rani, Associate Professor, Department of Pathology,Tagore medical college and hospital, Chennai, Tamilnadu, India
Associate Professor Pathology
Duraipandian Jeyakumari, Professor, Department of Microbiology, Tagore Medical college and Hospital, Rathinamangalam, Chennai-600127, Tamilnadu, India
Professor, Department of Microbiology,
Madasamy Balamurugan, Professor and HOD, Department of Pathology, Tagore Medical college and Hospital, Rathinamangalam, Chennai-600127, Tamilnadu, India
Professor and HOD, Department of Pathology
Aruna V Padmavathi, Assistant Professor, Department of Pathology, Tagore Medical college and Hospital, Rathinamangalam, Chennai-600127, Tamilnadu, India
Assistant Professor, Department of Pathology
Kolsamma Nasrin, Assistant Professor, Department of Pathology, Tagore Medical college and Hospital, Rathinamangalam, Chennai-600127, Tamilnadu, India
Assistant Professor, Department of Patholog

References

1. Khuroo MS, Khuroo MS, Khuroo NS. Transmission of Hepatitis E Virus in Developing Countries. Viruses. 2016 Sep 20;8(9).
2. Irshad M, Sharma Y, Dhar I, Singh J, Joshi Y-K. Transfusion-transmitted virus in association with hepatitis A-E viral infections in various forms of liver diseases in India. World J Gastroenterol. 2006 Apr 21;12(15):2432–6.
3. Pallavi P, Ganesh CK, Jayashree K, Manjunath GV. Seroprevalence and trends in transfusion transmitted infections among blood donors in a university hospital blood bank: a 5 year study. Indian J Hematol Blood Transfus Off J Indian Soc Hematol Blood Transfus. 2011 Mar;27(1):1–6.
4. Juhl D, Baylis SA, Blümel J, Görg S, Hennig H. Seroprevalence and incidence of hepatitis E virus infection in German blood donors. Transfusion (Paris). 2014 Jan;54(1):49–56.
5. Arankalle VA, Chobe LP. Retrospective analysis of blood transfusion recipients: evidence for post-transfusion hepatitis E. Vox Sang. 2000;79(2):72–4.
6. Khuroo MS, Kamili S, Yattoo GN. Hepatitis E virus infection may be transmitted through blood transfusions in an endemic area. J Gastroenterol Hepatol. 2004 Jul;19(7):778–84.
7. Hewitt PE, Ijaz S, Brailsford SR, Brett R, Dicks S, Haywood B, et al. Hepatitis E virus in blood components: a prevalence and transmission study in southeast England. Lancet Lond Engl. 2014 Nov 15;384(9956):1766–73.
8. Anti Hepatitis E Virus Seropositivity in a Group of Blood Donors (PDF Download Available) [Internet]. [cited 2017 Jan 24]. Available from: https://www.researchgate.net/publication/237261115_Anti_Hepatitis_E_Virus_Seropositivity_in_a_Group_of_Blood_Donors
9. Bortoliero AL, Bonametti AM, Morimoto HK, Matsuo T, Reiche EMV. Seroprevalence for hepatitis E virus (HEV) infection among volunteer blood donors of the Regional Blood Bank of Londrina, State of Paraná , Brazil. Rev Inst Med Trop Sao Paulo. 2006 Apr;48(2):87–92.
10. Takahashi M, Tamura K, Hoshino Y, Nagashima S, Yazaki Y, Mizuo H, et al. A nationwide survey of hepatitis E virus infection in the general population of Japan. J Med Virol. 2010 Feb;82(2):271–81.
11. Daniel HDJ, Warier A, Abraham P, Sridharan G. Age-wise exposure rates to hepatitis e virus in a southern Indian patient population without liver disease. Am J Trop Med Hyg. 2004 Nov;71(5):675–8.
12. Gajjar MD, Bhatnagar NM, Sonani RV, Gupta S, Patel T. Hepatitis E seroprevalence among blood donors: A pilot study from Western India. Asian J Transfus Sci. 2014 Jan;8(1):29–31.
13. Mateos ML, Camarero C, Lasa E, Teruel JL, Mir N, Baquero F. Hepatitis E virus: relevance in blood donors and other risk groups. Vox Sang. 1998;75(4):267–9.
14. Meng XJ, Wiseman B, Elvinger F, Guenette DK, Toth TE, Engle RE, et al. Prevalence of antibodies to hepatitis E virus in veterinarians working with swine and in normal blood donors in the United States and other countries. J Clin Microbiol. 2002 Jan;40(1):117–22.
15. Dalton HR, Stableforth W, Thurairajah P, Hazeldine S, Remnarace R, Usama W, et al. Autochthonous hepatitis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease. Eur J Gastroenterol Hepatol. 2008 Aug;20(8):784–90.
16. Ijaz S, Arnold E, Banks M, Bendall RP, Cramp ME, Cunningham R, et al. Non-travel-associated hepatitis E in England and Wales: demographic, clinical, and molecular epidemiological characteristics. J Infect Dis. 2005 Oct 1;192(7):1166–72.
17. Mansuy JM, Legrand-Abravanel F, Calot JP, Peron JM, Alric L, Agudo S, et al. High prevalence of anti-hepatitis E virus antibodies in blood donors from South West France. J Med Virol. 2008 Feb;80(2):289–93.
18. Anand AC, Singh KJ, Sharma P, Kumar S, Gupta RM. Incidence of Hepatitis E Virus Infection in Recipients of Blood or Blood Products Transfusion. Med J Armed Forces India. 2010 Jul;66(3):204–7.
19. Gotanda Y, Iwata A, Ohnuma H, Yoshikawa A, Mizoguchi H, Endo K, et al. Ongoing subclinical infection of hepatitis E virus among blood donors with an elevated alanine aminotransferase level in Japan. J Med Virol. 2007 Jun 1;79(6):734–42.
20. art22532.pdf [Internet]. [cited 2017 Jan 21]. Available from: http://www.eurosurveillance.org/images/dynamic/EE/V21N30/art22532.pdf
21. Original Article (Ravinder) - Vol1Issue3_41OA.pdf [Internet]. [cited 2017 Jan 21]. Available from: http://aimdrjournal.com/pdf/Vol1Issue3_41OA.pdf
22. Retrospective serological analysis of hepatitis E patients: a long-term follow-up study. [Internet]. [cited 2017 Jan 24]. Available from: http://www.medscape.com/medline/abstract/10607264
23. Bajpai M, Gupta E. Transfusion-transmitted hepatitis E: Is screening warranted? Indian J Med Microbiol. 2011 Oct 1;29(4):353.
Published
2017-10-30
Issue
Vol 4 No 5 (2017)
Section
Original Article

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).