Cytohistological Correlation of Palpable Breast Mass: A Study of 300 Cases

  • Aditi Dharmesh Vasavada Gotri Medical College, Vadodara.
  • Sheetal Kher Dept of Pathology GMERS Medical College Gotri.
Keywords: Breast FNAC, Five tire system, malignant lesion.


Background: The present study is aimed at correlation of cytological and histological findings of palpable breast mass and evaluate efficacy of FNAC as a first line of investigation modality in breast lump.Material Method: Total 378 female patients with breast lump were subjected to fine needle aspiration cytology examination and reported by using five tire system for  breast cytology. Out of 378 cases, in 300 cases cytological findings were correlated with histological diagnosis.Results: In present study, all benign, malignant and suspicious cases on cytology were well correlated with their histological diagnosis. The sensitivity, specificity and positive predictive value of FNAC for palpable breast lump are 97.7%, 98.8% and 97.7% respectively.Conclusion:  FNAC of breast lump is an effective, rapid, cost effective, though simple diagnostic procedure with excellent patient compliance.  It is giving high accuracy rates when practiced by and experienced hand; making it one of the most reliable modality for evaluation of palpable breast mass. DOI: 10.21276/APALM.1385


1. Globocan 2012 - Home [Internet]. [cited 2017 Jul 13]. Available from:

2. Mitra S, Dey P. Fine-needle aspiration and core biopsy in the diagnosis of breast lesions: A comparison and review of the literature. Cytojournal. 2016;13:18.

3. Panjvani SI. Utility of Fine Needle Aspiration Cytology in the Evaluation of Breast Lesions. J Clin Diagnostic Res. 2013;2777–9.

4. Khan A, Jamali R, Jan M, Tasneem M. Correlation of Fine Needle Aspiration Cytology and Histopathology Diagnosis in the Evaluation of Breast Lumps. Int J Med Students. 2014;2(2):40–3.

5. Ahmed I, Nazir R, Chaudhary MY, Kundi S. Triple assessment of breast lump. J Coll Physicians Surg Pak. 2007 Sep;17(9):535–8.

6. Bukhari MH, Akhtar ZM. Comparison of accuracy of diagnostic modalities for evaluation of breast cancer with review of literature. Diagn Cytopathol. 2009 Jun 1;37(6):416–24.

7. Goyal P, Sehgal S, Ghosh S, et al., “Histopathological Correlation of Atypical (C3) and Suspicious (C4) Categories in Fine Needle Aspiration Cytology of the Breast,” International Journal of Breast Cancer, 2013, Article ID 965498, 5 pages, 2013. doi:10.1155/2013/965498.

8. Ferguson CM, Powell RW. Breast masses in young women. Arch Surg. 1989 Nov;124(11):1338–41.

9. Murali U, Cunden SM. Clinico-pathological Correlation of Breast lumps in Mauritian women. IOSR J Dent Med Sci Ver I. 2015;14(7):2279–861.

10. Singh P, Chaudhry M, Nauhria S, Rao D. Cytomorphological patterns of breast lesions diagnosed on fine-needle aspiration cytology in a tertiary care hospital. Int J Med Sci Public Heal Int J Med Sci Public Heal Online. 2015;4(5).

11. Daramola AO, Odubanjo MO, Obiajulu FJ, Ikeri NZ, Banjo AAF. Correlation between Fine-Needle Aspiration Cytology and Histology for Palpable Breast Masses in a Nigerian Tertiary Health Institution. Int J Breast Cancer. 2015;2015.

12. Nasuti JF, Gupta PK, Baloch ZW. Diagnostic value and cost-effectiveness of on-site evaluation of fine-needle aspiration specimens: Review of 5,688 cases. Diagn Cytopathol. 2002 Jul;27(1):1–4.

13. Anderson L, Melamed MR. Koss’ apostrophe, Diagnostic Cytology and Its Histopathologic Bases. Pathology. 2006 Apr 1;38(2):193.

14. Yeoh GP, Chan KW. Fine needle aspiration of breast masses: an analysis of 1533 cases in private practice. Hong Kong Med J. 1998;4(3):283–8.

15. Srilakshmi HP, Chavda J. A Study Of Cyto-Histological Correlation Of Breast Lesions. 2013;4(September 2010):54–6.

16. Chauhan N, Pathak VP, Saini S, Singh Gaur D. Indian Medical Gazette Cytohistopathological Correlation in Palpable Breast Lesions. 2012;
Original Article

Most read articles by the same author(s)