Histomorphological Study Of Ovarian Tumors: At A Tertiary Care Centre

  • Rashmi K Patil Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India
  • Bhumika Jeevanraj Bhandari Belagavi institute of medical sciences, Belagavi, Karnataka
  • Shreekant K Kittur Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India
  • Rekha M Haravi Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India
  • Aruna S Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India
  • Meena N Jadhav Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India
Keywords: Ovarian tumors, Surface epithelial, Serous cystadenoma, Endometroid.

Abstract

Background: Ovarian tumors account for about 30% of female genital tract tumors and is fourth leading cause of cancer deaths in females. This study was conducted to evaluate the frequency and distribution of histological types of ovarian tumors.  Methods: This was a retrospective seven years observational study based on histomorphological evaluation of 151 ovarian tumours received in department of pathology. Statistical analysis was done and chi-square test was used to see the association. Results: Out of 151 cases, 149 were primary ovarian tumors and two were metastatic tumors to ovary. There were 124 benign tumors, one was borderline and 26 were malignant. Most common age group affected was 31 to 45 years. Benign tumors were common in 16 to 30 years age group, whereas malignant tumors in 46-60 years. For all age group, benign tumors were more common than malignant tumors. Surface epithelial tumors (72.2%) were the most common followed by germ cell tumors (19.9%) and then sex cord stromal tumors (6.6%). Serous cystadenoma (41.93%) was the most common benign tumor followed by mucinous cystadenoma (32.25%). Serous cystadenocarcinoma (38.46%) was the most common malignant tumor. Most common germ cell tumor was mature cystic teratoma (73.3%) and granulosa cell tumor (50%) was the most common sex cord stromal tumor.Conclusion: Diagnosis of neoplastic ovarian lesions requires correlation between clinical, gross and microscopy features as the morphologic diversity of ovarian tumors poses many challenges. In difficult cases, immunohistochemistry and molecular diagnosis may be often required.

Author Biographies

Rashmi K Patil, Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India
Associate professor, Department of Pathology
Bhumika Jeevanraj Bhandari, Belagavi institute of medical sciences, Belagavi, Karnataka
Post graduate, Department of Pathology
Shreekant K Kittur, Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India
Professor and head, department of pathology
Rekha M Haravi, Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India
Associate professor, Department of Pathology
Aruna S, Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India
Associate professor, Department of Pathology
Meena N Jadhav, Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India
Associate professor, Department of Pathology

References

1) Sharma I, Sarma U, Dutta UC. Pathology of ovarian tumour- A hospital based study. International journal of medical science and clinical invention 2014;1(6):284-6.

2)Basu P, De P, Mandal S, Ray K, Biswas J. Study of 'patterns of care' of ovarian cancer patients in a specialized cancer institute in Kolkata, eastern India. Indian J Cancer 2009;46:28-33.

3) Nishal AJ, Naik KS, Modi J. Analysis of spectrum of ovarian tumours: a study of 55 cases. Int J Res Med Sci 2015;3(10):2714-7.

4) Kuladeepa AVK, Muddegowda PH, Lingegowda JB, Doddikoppad MM, Basavaraja PK, Hiremath SS. Histomorphological study of 134 primary ovarian tumours. Adv Lab Med Int 2011;1(4):69-82.

5) Sen U, Sankaranarayanan R, Mandal S, Romana AV, Parkin DM, Siddique M. Cancer patterns in Eastern India. The first report of Kolkata Cancer Registy. Int J Cancer 2002;100(1):86-91.

6) Singh S, Saxena V, Khatri SL, Gupta S, Garewal J, Dubey K. Histopathological evaluation of ovarian tumors. Imperial journal of Interdisciplinary Research 2016;2(4):435-9.

7) Jha R, Karki S. Histological pattern of ovarian tumors and their age distribution. Nepal Med Coll J 2008;10(2):81-5.

8) Tejeswini V, Reddy ES, Premalatha P , Vahini G. Study of morphological patterns of ovarian neoplasms. Journal of Dental and Medical Sciences 2013:10(6):11-6.

9) Modi D, Rathod GB, Delwadia KN, Goswami HM. Histopathological pattern of neoplastic ovarian lesions. International Archives of Integrated Medicine 2016;3(1):51-7.

10) Ahmad Z, Kayani N, Hasan SH, Muzaffar S, Gill MS. Histological pattern of ovarian neoplasms. J Pak Med Assoc 2000;50(12):416-9.

11) Mondal SK, Banyopadhyay R, Nag DR, Roychowdhury S, Mondal PK, Sinha SK. Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: A 10-year
study in a tertiary hospital of eastern India. J Cancer Res Ther 2011;7:433-7.

12) Malli M, Vyas B, Gupta S, Desai H. A histological study of ovarian tumors in different age groups. Int J Med Sci Public Health 2014;3:338-41.

13) Yogambal M, Arunalatha P, Chandramouleeshwari K, Palaniappan V. Ovarian tumours- Incidence and distribution in a tertiary referral center in south India. Journal of Dental and Medical Sciences 2014:3(2):74-80.

14) Guppy AE, Nathan PD, Rust n GJ. Epithelial ovarian cancer: A review of current management. Clin oncol 2005;17:399-411.

15) Gupta N, Bisht D, Agarwal AK, Sharma VK. Retrospective and prospective study of ovarian tumours and tumour-like lesions. Indian J Pathol Microbiol 2007;50:525-7.

16) Danish F, Khanzada MS, Mirza T, Aziz S, Naz E, Khan MN. Histomorphological spectrum of ovarian tumors with immunohistochemical analysis of poorly or undifferentiated malignancies. Gomal J Med Sci 2012;10(2):209-15.

17) Pilli GS, Suneeta KP, Dhaded AV, Yenni VV. Ovarian tumours: a study of 282 cases: J Indian Med Assoc 2002;100:423-4.

18) Mankar DV, Jain GK. Histopathological profile of ovarian tumours: A twelve year institutional experience. Muller J Med Sci Res 2015;6:107-11.

19) Swamy GG, Satyanarayana N. Clinicopathological analysis of ovarian tumours- A study on five years samples. Nepal Med Coll J 2010;12(4):221-3.

20) Yasmin S, Yasmin A, Asif M. Clinicohistological Pattern of Ovarian Tumors in Peshawar Region. J Ayub Med Coll Abbotabad 2008;20(4):11-3.
Published
2017-12-18
Section
Original Article