ABO Blood groups and Malaria: Does it really matter?
Keywords:
malarial parasites, ABO blood group, malaria, parasite load
Abstract
Background: Malaria is most important parasitic disease affecting humans. The literature relating to malaria and the blood groups are sparse and have mixed response.Objectives: The study was undertaken to assess the distribution of ABO blood group and their relationship with malaria species and parasite load.Methods: In 200 malaria positive patients blood group analysis was done. Malaria parasite detection and load estimation was done using quantitative buffy coat (QBC) methodology using a fluorescent microscopy. ABO blood group was determined by agglutination test using antisera.Results: A total of 200 were included in the study of which 121 cases were positive for plasmodium vivax, 32 cases were positive for plasmodium falciparum and 47 patients had mixed infection. The results of blood groups showed, 63 malaria infected patients with A blood group, 50 with B blood group, 80 with O blood group and 7 with AB blood group. Maximum parasite load was noted in blood group O, followed by group A and B. The most common blood group infected with plasmodium vivax is blood group O, similarly with 3+and 4+ parasite load is blood group O.Conclusion: This study suggests significantly higher proportion of O blood group malaria patients infected with plasmodium vivax with higher parasite load.References
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2.Otajevvo FD. Prevalence of malaria parasitemia and its association with ABO blood grouping among students of Igbinedion university Okada, Nigeria. Br J Med Res 2013;3:1164-77.
3.Deepa, Vanamala A, Karuna R, Cecil R. ABO blood group and malaria related outcome. J vector borne Dis 48, March 2011:7-11.
4.Tewodros Z, Abraham D, Berhanu E. Association of ABO blood group and Plasmodium falciparum malaria in Dore Bafeno area, Southern Euthopia. Asian Pac J Trop Biomed 2011;1;289-294.
5.Singh G, Urhekar AD, Singh R. A study on correlation of malaria infection with A,B,O, RH blood group system. J Parasitol Vector Biol 2015;7:67-73.
6.Gayathri BN, Harendra KML, Gomathi N, Jeevan S, Reethesh PP. Relationship between ABO blood groups and malaria with clinical outcome in rural area of South India. Glob J Med. Public Health 2013;2:1-7.
7.Sule HA, Idachaba SO, Idoko T. Susceptibility of humans of the ABO blood groups to P falciparum infection among patients attending Ahmadu Bello University clinic (Sickbay), Samaru-Zaria, Kaduna state, Nigeria. Sch J App Med Sci 2014;2:1305-9.
8.Sharanya H, Ruchi S, Shrijeet C, Lavnish O. Relationship between malaria and ABO blood group type. Int J Sci Res 2016;5:1041-44.
9.Chandrika R, Jayaprakash S. Frequency of ABO and Rhesus (D) blood groups in Dakshina Kannada district of Karnataka: A study from rural tertiary care teaching hospital in South India. NUJHS 2014;4:57-60.
10.Singh N, Shukla MM, Uniyal VP. ABO blood groups among malaria cases from district Mandla, Mandya Pradesh. Indian J Malariol 1995;32:59-63.
11.Fry AF, Griffiths MJ, Auburn S, Diakite M, Forton JT, Green A, et al. Common variations in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria. Hum Mol Genet 2008;17:567-76.
Published
2017-12-18
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