Clinical and Histopathological Correlation in Hansen’s Disease

  • Muruganantham Arunagirinathan GOVERNMENT VELLORE MEDICAL COLLEGE AND HOSPITAL, VELLORE. TAMIL NADU, INDIA.
  • Vennila Muniswamy GOVERNMENT VELLORE MEDICAL COLLEGE & HOSPITAL, VELLORE.
  • Sivaraman Jeevirathinam GOVERNMENT VELLORE MEDICAL COLLEGE & HOSPITAL, VELLORE.
Keywords: Clinical diagnosis, Histopathological diagnosis, Leprosy, Fite Faraco stain, agreement, disagreement.

Abstract

BACKGROUND: The  present  study  was  carried out  to  correlate  clinical  diagnosis  of  new  leprosy  cases  with  that  of  histopathological  diagnosis  of  skin  biopsies  stained  with  Haematoxylin  and  Eosin  followed  by  Fite  Faraco  stain.METHOD: Skin  biopsies of  70 newly  diagnosed  leprosy  patients  were  fixed  in  10% formalin  and  routine  histopathological  examination done  followed  by  special  stain ( Fite  Faraco )  to  evaluate  the  bacterial  index. RESULTS: From  this  study  it  was  observed  that,  the  commonest  age  group  affected  by  leprosy  was  31  to  50  years,  males  are  twice  more  commonly  affected  than  females ( M:F = 1.9 : 1 )  and  the  most  commonest  clinically  diagnosed  spectrum  was  Tuberculoid leprosy  ( TT ).  The  commonest  histopathologically  diagnosed  spectrum  was  Indeterminate  leprosy( IL ). It  was  observed  that  there  was  complete  agreement  between  clinical  diagnosis  and  histopathological  diagnosis  in  62.85%  cases  and  disagreement was  observed  in  37.15%  cases.CONCLUSION: In  case  of  confirmed   discrepancy,  the  more  advanced  findings ( ie.  towards  the  lepromatous  pole )  should  be  given  greater  weightage  and  the  case  is  to  be  classified  and  treated  accordingly. DOI: 10.21276/APALM.1462

Author Biographies

Muruganantham Arunagirinathan, GOVERNMENT VELLORE MEDICAL COLLEGE AND HOSPITAL, VELLORE. TAMIL NADU, INDIA.
DEPARTMENT OF PATHOLOGY, ASSISTANT  PROFESSOR.
Vennila Muniswamy, GOVERNMENT VELLORE MEDICAL COLLEGE & HOSPITAL, VELLORE.
DEPARTMENT  OF  PATHOLOGY,ASSISTANT  PROFESSOR
Sivaraman Jeevirathinam, GOVERNMENT VELLORE MEDICAL COLLEGE & HOSPITAL, VELLORE.
DEPARTMENT  OF  PATHOLOGY,ASSISTANT  PROFESSOR

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Published
2017-08-31
Issue
Vol 4 No 4 (2017)
Section
Original Article

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