A study of Giant Cell Lesions of Bone
Keywords:
Osteoclast, Giant cell, Malignant
Abstract
Introduction:Giant cell lesions of bone include true giant cell tumors & numerous benign osteoclasts and pseudo-anaplastic-appearing giant cells containing variants.Many times it is difficult to differentiate between true giant cell tumor and other tumor like conditions.Aims:To study histopathology of various giant cell rich tumor and tumor like conditions of bone.Methods and Material: Retrospective analysis of 50 cases of giant-cell rich lesions of bone diagnosed and treated at Smt. N.H.L. Municipal Medical College Ahmedabad, Gujarat during 1st January 2002 to 1st January 2003 included in the study. Patients’ clinical, radiological details, histopathological examination were studied using structured proforma. The cases were classified in different categories according to age groups, types of tumour, benign versus malignant category.Results: The most common giant cell containing benign tumor is giant cell tumor (19 cases) followed by Aneurysmal bone cyst (5), Most of the giant cell containing tumors of bone are found in younger age group and are located in epiphysis The common giant cell containing malignant tumor is osteogenic sarcoma (7 cases) followed by Talangiectatic O.S (01). The majority of cases found in age between 15 - 28 years and most common sites are epiphysis of long bones.Conclusion:The most common giant cell rich benign bone tumor is giant cell tumor and most common giant cell rich malignant bone tumor is osteosarcoma commonly occurs in younger age groups in the epiphysis region long bonesDOI:10.21276/APALM.1524References
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13)Kumavat PV, Gadgil NM, Chaudhari CS, Rathod UK, Kshirsagar GR, Margam SS. Bone Tumors and Tumor-like lesions: A study in A Tertiary Care Hospital, Mumbai. Ann Lab Med 2017;4(1):A-11-18
14) Bamanikar SA, Pagaro PM, Kaur P, Chandanwale SS, Bamanikar A, Buch AC. Histopathological Study of Primary Bone Tumours and Tumour-Like Lesions in a Medical Teaching Hospital. JKIMSU 2015;4(2):46-55.
2) Chakarun CJ, Forrester DM, Gottsegen CJ, Patel DB, White EA, Matcuk GR, Jr, Giant Cell Tumor of Bone: Review, Mimics, and New Developments in Treatment, RadioGraphics 2013; 33:197–211.
3) Athanasou NA, Bansal M, Forsyth R, et al. Giant cell tumour of bone. In: Fletcher CD, Bridge JA, Hogendoorn PC, eds. WHO Classification of tumour of soft tissues. Lyon, France: IARC Press 2013; 321-324
4) Flanagan AM, Tirabosco R, Gikas PD. Osteoclast-rich lesions of bone: a clinical and molecular overview. In: D ominique H eymann editor. Bone Cancer, 2nd ed. San Diego, USA: Elsevier; 2015. p. 257-272.
5) Gupta R, Seethalakshmi V, Jambhekar NA, et al. Clinicopathologic profile of 470 giant cell tumours of bone from a cancer hospital in western India. Ann Diagn Pathol 2008;12(4):239-248.
6) Cowman RW, Singh G. Giant cell tumor of bone: a basic science perspective. Bone 2013;52:238-246
7) Horvai A. Bones, joints and soft tissue tumours. In: Kumar V, Abbas AK, Fausto N, Aster JC, editors. Robbins and cotran; Pathologic Basis of disease. 9th ed. Philadelphia: Elsevier, Saunders; 2015. p.1180-1224.
8) Rosenberg A.E., Nielsen G.P. Giant cell containing lesions of bone and their differential diagnosis. Diagn Histopathol 2001;7(4):235-246
9) Goldenberg RR, Campbell CJ, Bonfiglio M. Giant-cell tumour of bone. An analysis of 218 cases. J Bone Joint Surg Am 1970;52(4):619-663.
10) BalkeM, Schremper L, Gebert C, Ahrens H, Streitbuerger A, Koehler G et al. Giant cell tumor of bone: treatment and outcome of 214 cases. J Cancer Res Clin Oncol 2008;134:969–978.
11) Zheng MH, Robbins P, Xu J, Huang L, Wood DJ, Papadimitriou JM. The histogenesis of giant cell tumour of bone: a model of interaction between neoplastic cells and osteoclasts. Histol Histopathol 2001;16(1):297-307.
12) Modi VM, Modi MB, Jetly DH, Mehta SP, Kundariya M, et al. Primary Giant Cell-Rich Lesions of Bone with Role of Denosumab - Histopathological Study with Clinico-Radiological Correlation. Int Clin Pathol J 3(1): 00066. DOI: 10.15406/icpjl.2016.03.00066
13)Kumavat PV, Gadgil NM, Chaudhari CS, Rathod UK, Kshirsagar GR, Margam SS. Bone Tumors and Tumor-like lesions: A study in A Tertiary Care Hospital, Mumbai. Ann Lab Med 2017;4(1):A-11-18
14) Bamanikar SA, Pagaro PM, Kaur P, Chandanwale SS, Bamanikar A, Buch AC. Histopathological Study of Primary Bone Tumours and Tumour-Like Lesions in a Medical Teaching Hospital. JKIMSU 2015;4(2):46-55.
Published
2017-10-27
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