Histopathological Interpretation Of Colonic Mucosal Biopsies With Clinical Correlation: A Study In A Tertiary Care Hospital Kerala
Keywords:
Colonoscopy, Colitis, Adenoma, Adenocarcinoma
Abstract
Background: Colon is the most common site for various diseases. Diseases affecting the colon may cause abdominal pain, constipation, diarrhea and bleeding per rectum. Colonoscopy is endoscopic examination of the colon with a flexible optic fibers, this method allows visual examination of colonic mucosa and provides opportunity for mucosal biopsies. This study was carried out to study and correlate histopathological spectrum of colonic mucosal biopsies with clinical findings.Methods: This two years study was conducted during the period of April 2015 to March 2017. 250 colonoscopic biopsies were included in the study. All biopsies were fixed in formalin, processed as per routine histopathology processing, stained with Hematoxylin & Eosin stains and studied.Results: Out of 250 colonoscopic biopsies, 152 were non-neoplastic and 98 were neoplastic. Non neoplastic lesions were found to affect the colon most commonly. Most of the cases with non-neoplastic lesions presented with colicky abdominal pain, diarrhea and constipation. Among neoplastic lesions, 44 cases were benign and 54 cases were malignant. Majority of cases with neoplastic lesions presented with bleeding per rectum and constipation.Conclusion: Non neoplastic lesions were found to affect the colon most commonly. This study emphasize the increase in incidence of ulcerative colitis and colorectal carcinomas. Histopathological interpretation on colonic mucosal biopsies has taken a cornerstone in the diagnosis and management of patients with colonic lesions.DOI:10.21276/APALM.1534References
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22.Sulegaon R, Shete S, Kulkarni D. Histological Spectrum of Large Intestinal Lesions with Clinicopathological Correlation. Journal of Clinical and Diagnostic Research. 2015,9(11): EC30-EC34
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24.Saidi HS, Karuri D, Nyaim EO: Correlation of clinical data, anatomical site and discuss stage in colorectal cancer. East Afr Med J:2008;85:259-62.
25.Caliskan C, Guler N, Karaca C, Makay O, Firat O, Korkut MA. Negativeprognostic factors in colorectal carcinoma: an analysis of 448 patients.Indian J Surg. 2010;72:243-48.
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28.Laishram RS, Kaiho N, Shimray R, Devi SB, Punyabati P, Sharma DC. Histopathological Evaluation of Colorectal Carcinomas status in Manipur, India. International Journal of Pathology:2010; 8(1):5-8.
29.Gurjeet K, Abdelhafid M, et al. Mismatch repair genes expression defects & association with clinicopathological characteristics in colorectal carcinoma. Indian J Med Res 2011;134(2):186-192.
30.Shyamal Kumar Halder et al. Epidemiological, Clinico-Pathological Profile and Management of Colorectal Carcinoma in a Tertiary Referral Center of Eastern India. JKIMSU, 2013; 2(1):45-50.
2.Boyle P, Langman JS. ABC of colorectal cancer: Epidemiology. BMJ 2000;321(7264):805–808
3.Cappell MS, Friedel D. The role of sigmoidoscopy and colonoscopy in the diagnosis and management of lower gastrointestinal disorders: endoscopic findings, therapy and complication. Med Clin North Am 2002 Nov;86:1253-88
4.Greene FL, Livstone EM, Troncale FJ. The role of fibreoptic colonoscopy in the diagnosis of colonic and rectal diseases. Comm Med.1973;37:439-42.
5.Chutkan RK, Waye JD. Endoscopy in Inflammatory bowel disease. In: KirsnerJB,ed. Inflammatory bowel disease.5th ed. Baltimare : Williams & Wilkins:2000:453-777
6.Siddique I, Mohan K, Hasan F, Memon A,Patty I, Al-Nakib B. Appropriateness of indication and diagnostic yield of colonoscopy : First report based on the 2000 guidelines of the American Society for Gastrointestinal Endoscopy. World J Gastroenterol 2005;11(44):7007-13.
7.Deshpande V, Hsu M, Kumarasinghe MP, et al. The clinical significance of incidental chronic colitis: a study of 17 cases. Am J SurgPathol 2010; 34(4):463-9.
8.Gill MK, Jain K, Manjari M, Kaur T. Expression of Her-2/neu in Colon Carcinoma and Its Correlation with the Histological Grades and the Lymph nodes status. Journal of Clinical and Diagnostic Research.2011 December, Vol-5(8): 1564-68.
9.Karve SH, Vidya K, Shivarudrappa A.S et al. The Spectrum of colonic lesions: A Clinico-pathological study of colonic biopsies. Indian Journal of Pathology and Oncology, October – December 2015;2(4);189-209
10.Azad S, Sood N, Sood A. Biological and Histological Parameters as Predictors of Relapse in Ulcerative colitis: A prospective study. Saudi J Gastroenteral 2011 May-Jan;17(3): 194-198.
11.Qayyum SA, Sawan SA. Profile of colonic Biopsies in King Abdul Aziz University Hospital, Jeddah. J Pak Med Assoc 2009;59(9):608-11.
12.Paudel SMR, Sharma VK. Ulcerative colitis- is it the clinical problem in Nepal? PMJN.2007;7(2):1-6.
13.Rajbhandari M, Karmacharya A, Khanal K, Dhakal P, Shrestha R. Histomorphological Profile of Colonoscopic Biopsies and Pattern of Colorectal Carcinoma in Kavre District. Kathmandu Univ Med J 2013;43(3):196-200.
14.Pandey MS, Pandey A et al. Histomorphological Profile of Colonoscopic Biopsies - A Two Year Study in a Tertiary Care Hospital in South India. International Journal of Science and Research (IJSR). 2016;5 (2): 1513-18
15.Badmapriya D, Kumar VS. Profile of Ulcerative colitis in South India Region: Karaikal. IJPBS 2011;1(2):47-51
16.Sood A, Vandana M, et al. Profile of Ulcerative Colitis in a North India Hospital. Journal of Indian Academy of Clinical Medicine 1998; 5(2):124-128.
17.Williams GT, Arthur JF, Bussey HJ, Morson BC. Metaplastic polyps and polyposis of the colorectum. Histopathology.1980;4(2):155-70.
18.Price AB, Morson BC. Inflammatory bowel disease: The surgical pathology of Crohn’s disease and ulcerative colitis. Hum Pathol.1975;6(1):7-29.
19.Sood A, Midha V, Sood N, Bhatia AS, Avasthi G. Incidence and prevalence of ulcerative colitis in Punjab, North India. Gut. 2003;52(11):1587-90.
20.Konishi F, Morson BC. Pathology of colorectal adenomas. A colonoscopic survey. J Clin Pathol. 1982;35(8): 830-41.
21.Tony J, Harish K, Ramachandran TM, Sunilkumar K, Thomas V. Profile of colonic polyps in a southern Indian population. Indian J Gastroenterol. 2007;26(3):127-29.
22.Sulegaon R, Shete S, Kulkarni D. Histological Spectrum of Large Intestinal Lesions with Clinicopathological Correlation. Journal of Clinical and Diagnostic Research. 2015,9(11): EC30-EC34
23.Yawe KT, Bakeri AA, Pindiga UH, et al. Clinicopathological pattern and challenges in the management of colorectal cancer in sub-saharan Africa. J Chinese Clin Med 2007;2:688-95.
24.Saidi HS, Karuri D, Nyaim EO: Correlation of clinical data, anatomical site and discuss stage in colorectal cancer. East Afr Med J:2008;85:259-62.
25.Caliskan C, Guler N, Karaca C, Makay O, Firat O, Korkut MA. Negativeprognostic factors in colorectal carcinoma: an analysis of 448 patients.Indian J Surg. 2010;72:243-48.
26.Rasool A, Bari S, Rashid S, Wani AH, Wani RA, Peer GQ. Outcome of patients with acute intestinal obstruction due to colorectal carcinoma. The internet journal of surgery. 2009;20(1).
27.Sudarshan V, Hussain N, Gahine R, Mourya J. Colorectal cancer in young adults in a tertiary care hospital in Chattisgarh, Raipur. Indian Journal of Cancer, 2013; 50(4): 337-40.
28.Laishram RS, Kaiho N, Shimray R, Devi SB, Punyabati P, Sharma DC. Histopathological Evaluation of Colorectal Carcinomas status in Manipur, India. International Journal of Pathology:2010; 8(1):5-8.
29.Gurjeet K, Abdelhafid M, et al. Mismatch repair genes expression defects & association with clinicopathological characteristics in colorectal carcinoma. Indian J Med Res 2011;134(2):186-192.
30.Shyamal Kumar Halder et al. Epidemiological, Clinico-Pathological Profile and Management of Colorectal Carcinoma in a Tertiary Referral Center of Eastern India. JKIMSU, 2013; 2(1):45-50.
Published
2017-10-27
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