Castleman Disease- An Uncommon And Intriguing Condition Revisited: A Report Of Two Cases
Keywords:
Lymph node, Castleman disease, Hyaline vascular, Mixed variant
Abstract
Castleman disease (CD) also called as angiofollicular hyperplasia or giant lymph node hyperplasia of unknown cause is a benign lymphoproliferative disorder. It is a localised (unicentric) or disseminated (multicentric) disease. This disease is uncommon with an incidence of 25 cases per million person per year. Castleman disease is a heterogeneous group of disorders with four characteristic histological variants. The etiology of this disease is poorly understood. We report two cases of CD, one presenting with a neck mass and the other presenting with para-aortic and mesenteric lymphadenopathy which were classified as hyaline vascular type and mixed type of CD respectively.DOI: 10.21276/APALM.1559References
1. Johkoh T, Muller NL, Ichikado K, et al. Intrathoracic multicentric Castleman disease: CT findings in 12 patients. Radiology 1998; 209: 477-481.
2. Castleman B, Iverson L, Menendez VP. Localized mediastinal lymph node hyperplasia resembling thymoma. Cancer 1956; 9: 822-830.
3. Castleman B, Towne VW. Case records of the Massachusetts General Hospital: Case No. 40231. N Engl J Med 1954; 250: 1001-1005.
4. Cervantes C E, Correa R. Castleman disease: A rare condition with endocrine manifestations. Cureus 2015; 7: e380.
5. Frizzera G, Banks PM, Massarelli G, Rosai J. A systemic lymphoproliferative disorder with morphologic features of Castleman’s disease. Pathological findings in 15 patients. Am J Surg Pathol 1983; 7: 211-231.
6. Saeed-Abdul-Rahman I, Al-Amri AM. Castleman disease. The Kor J Hematol. 2012;47:163-77.
7. Halac M, Ergul N, Sager S, Demir A, Buyukpinarbasli N, Sonmezoglu K. PET/CT findings in a multicentric form of Castleman’s disease. Hell J Nucl Med. 2007 Sep 3;10:172-4.
8. Chan KL, Lade S, Prince HM, Harrison SJ. “Update and new approaches in the treatment of Castleman’s disease,” J Blood Med 2016;7:145–158.
9. Hsu MY, Ng KK, Ko SF, Cheung YC, Lui KW, Wang JJ, Chan SC, Jung SM, Ng SH. Multicentric Plasma Cell Castleman’s disease associated with POEMS syndrome. Chin J Radiol 2009;34:113-7.
10. Gaba AR., Stein RS., Sweet DL, Variakojis D. Multicentric giant lymph node hyperplasia. Am J Clin Pathol. 1978;69:86–90.
11. Iyer S, Bhatti MI, Halliday M. Castleman's disease—A case report. Int J of Sur Case Reports. 2010; 31:25-6.
12. Menezes BF, Morgan R, Azad M. Multicentric Castleman's disease: a case report. J Med Case Reports. 2007; 1(1):78.
13. Mylona EE, Baraboutis IG, Lekakis LJ, Georgiou O, Papastamopoulos V, Skoutelis A. Multicentric Castleman's disease in HIV infection: a systematic review of the literature. AIDS Rev 2008;10(1):25-35.
14. Filliatre-Clement L, Busby-Venner H, Moulin C, Roth-Guepin G, Perrot A. Hodgkin lymphoma and Castleman disease: when one blood disease can hide another. Case Reports in Hematology 2017; Article ID 9423205 pg 1-3.
2. Castleman B, Iverson L, Menendez VP. Localized mediastinal lymph node hyperplasia resembling thymoma. Cancer 1956; 9: 822-830.
3. Castleman B, Towne VW. Case records of the Massachusetts General Hospital: Case No. 40231. N Engl J Med 1954; 250: 1001-1005.
4. Cervantes C E, Correa R. Castleman disease: A rare condition with endocrine manifestations. Cureus 2015; 7: e380.
5. Frizzera G, Banks PM, Massarelli G, Rosai J. A systemic lymphoproliferative disorder with morphologic features of Castleman’s disease. Pathological findings in 15 patients. Am J Surg Pathol 1983; 7: 211-231.
6. Saeed-Abdul-Rahman I, Al-Amri AM. Castleman disease. The Kor J Hematol. 2012;47:163-77.
7. Halac M, Ergul N, Sager S, Demir A, Buyukpinarbasli N, Sonmezoglu K. PET/CT findings in a multicentric form of Castleman’s disease. Hell J Nucl Med. 2007 Sep 3;10:172-4.
8. Chan KL, Lade S, Prince HM, Harrison SJ. “Update and new approaches in the treatment of Castleman’s disease,” J Blood Med 2016;7:145–158.
9. Hsu MY, Ng KK, Ko SF, Cheung YC, Lui KW, Wang JJ, Chan SC, Jung SM, Ng SH. Multicentric Plasma Cell Castleman’s disease associated with POEMS syndrome. Chin J Radiol 2009;34:113-7.
10. Gaba AR., Stein RS., Sweet DL, Variakojis D. Multicentric giant lymph node hyperplasia. Am J Clin Pathol. 1978;69:86–90.
11. Iyer S, Bhatti MI, Halliday M. Castleman's disease—A case report. Int J of Sur Case Reports. 2010; 31:25-6.
12. Menezes BF, Morgan R, Azad M. Multicentric Castleman's disease: a case report. J Med Case Reports. 2007; 1(1):78.
13. Mylona EE, Baraboutis IG, Lekakis LJ, Georgiou O, Papastamopoulos V, Skoutelis A. Multicentric Castleman's disease in HIV infection: a systematic review of the literature. AIDS Rev 2008;10(1):25-35.
14. Filliatre-Clement L, Busby-Venner H, Moulin C, Roth-Guepin G, Perrot A. Hodgkin lymphoma and Castleman disease: when one blood disease can hide another. Case Reports in Hematology 2017; Article ID 9423205 pg 1-3.
Published
2018-01-12
Issue
Section
Case Report
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
