Gallbladder Carcinoma and Its Mimics

  • Praneeta Jaswant Singh Department of Pathology, K.D. medical College Hospital and Research Center, Akbarpur, Mathura, Uttar Pradesh, India. 281406
  • Sheetal G Gole Department of Pathology, World College of Medical Science & Research & Hospital, Gurawar, Jhajjar, Haryana, India
Keywords: Incidental gallbladder carcinoma, eumycetoma, biliary intraepithelial neoplasia, dysplasia, gallstone disease, India


Background: Symptomatic gallstone disease is most common indication for routine cholecystectomy. Gallstones cause various histological changes in gallbladder ranging from metaplasia to dysplasia and gallbladder carcinoma. Aims: Study was conducted to evaluate histopathological lesions in gallbladder diseases, correlate clinical and histopathological diagnoses in cholecystectomies and to know prevalence of incidental gallbladder carcinoma in our region.Material and method: All cholecystectomy specimens received in histopathology laboratory during study period of one year were included. Detailed gross and microscopic examination was done in each case. Slides were stained by Hematoxylin and Eosin stain. Results: Total 290 cholecystectomy specimens were studied over a period of one year. Clinically suspicion of gallbladder carcinoma was raised in five cases due to preoperative and intraoperative findings of thickened gallbladder wall with adherence to surrounding structures and presence of gallstones. On microscopy, three cases of these were reported as xanthogranulomatous cholecystitis, one as nonspecific chronic cholecystitis and one was rare case of eumycetoma of gallbladder. On histopathological examination suspicion of gallbladder carcinoma was raised in three cases of dysplasia and final diagnosis was biliary intraepithelial neoplasia-3 in two cases and biliary intraepithelial neoplasia-1 in one case. Histopathologically two cases (0.69%) were reported as gallbladder carcinoma and clinically there was no suspicion of gallbladder carcinoma in both cases. However in one case suspicion of gallbladder carcinoma was raised intraoperatively while one case was of incidental gallbladder carcinoma (0.34%).Conclusion: Gallstones disease can mimic gallbladder carcinoma clinically while incidental gallbladder carcinoma can occur in grossly normal looking gallbladder.DOI: 10.21276/APALM.1611

Author Biographies

Praneeta Jaswant Singh, Department of Pathology, K.D. medical College Hospital and Research Center, Akbarpur, Mathura, Uttar Pradesh, India. 281406
Associate professorDepartment of pathology
Sheetal G Gole, Department of Pathology, World College of Medical Science & Research & Hospital, Gurawar, Jhajjar, Haryana, India
Associate Professor, Department of Pathology


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Original Article