Study to Evaluate the Histopathological Spectrum of Hepatic Lesions in Liver Biopsies in a Tertiary Care Hospital
Keywords:
Hepatic lesions, Histopathological spectrum, Liver biopsy
Abstract
Background: Liver is affected by a wide spectrum of various primary and secondary diseases. These diseases can be diagnosed with the help of either clinical, biochemical or radiological examinations. But, liver biopsy remains the mainstay in diagnosis as well as management of various liver diseases.Methods: A prospective study which included 65 liver biopsies. The sections were examined and the histopathological findings were recordedResult: Out of 65 liver biopsies, 4.6% were inadequate for histopathological study. The various histopathological findings included secondary tumour deposits (40.0%), primary hepatic tumours (12.3%), hepatitis (16.9%), cirrhosis (12.3%), extrahepatic biliary atresia (6.15%), secondary biliary cirrhosis (3.0%), glycogen storage disease (1.5%), cystic hydatid disease (1.5%) and fatty liver (1.5%). Conclusion: The histopathological study of liver biopsy forms the cornerstone in the diagnosis and management of various hepatic diseases.DOI:10.21276/APALM.1667References
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2. Theise N.D. Liver and Gall Bladder. In: Kumar V., Abbas A.K., Aster J.C. Robbins and Cotran Pathologic Basis of Disease.9th ed. South Asia: Elsevier. 2015:821-80.
3. Chawla N., Sunila S. Spectrum of histopathological findings in liver biopsy. Indian Med Gaz. 2013:363-67.
4. Parekh P.J., Majithia R., Diehl D.L., Baron T.H. Endoscopic ultrasound-guided liver biopsy. Endosc Ultrasound. 2015;4(2):85-91.
5. Uchida T., Kao H., Quispe-Sjogren M., Peters R.L. Alcoholic foamy degeneration: A pattern of acute alcoholic injury of the liver. Gastroenterology. 1983;84:683-92.
6. Ohnishi K., Iida S., Iwana S., Goto N., Nomur F., Takashi A., et al. The effect of chronic habitual alcohol intake in the development of liver cirrhosis and hepatocellular carcinoma in relation to hepatitis B surface antigen carriage. Cancer. 1982;48:672-77.
7. Desmet V.J., Rosai J. Liver. In: Rosai and Ackerman’s surgical pathology.10th ed. Milan: Elsevier. 2012:857-965.
8. Umesh B.R., Gayathri B.N., Harendra Kumar M.L. Spectrum of liver pathology at autopsy. Int J Res Rev. 2015;2(3):79-86.
9. Kringsholm B., Christoffersen P. Liver pathology in fatal drug addiction. Forensic Sci Int. 1982;20(2):141-51.
10. Passarino G., Ciccone G., Siragusa R., Tappero P., Mollo F. Histopathological findings in 851 autopsies, with toxicological and virological correlations. Am J Forensic Med Pathol. 2005;26(2):106-16.
11. Gall E.A. Posthepatic, post necrotic and nutritional cirrhosis: A Pathologic analysis. Am J Pathol. 1960;36:241-70.
12. MacSween R.N.M., Scott A.R. Hepatic cirrhosis: A Clinicopathological review of 520 cases. J Clin Pathol. 1973;26:936-42.
13. Zafrani E.S. Nonalcoholic fatty liver disease. An emerging pathological spectrum.Virchows Arch. 2004;444:3.
14. Bedossa P., Poitou C., Veyrie N., Bouillot J., Basdevant A., Paradis V., Tordjman J., Clement K. Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients. Hepatology. 2012;56(5):1751-59.
Published
2018-03-22
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