“A prospective study on effects of tobacco consumption on semen parameters”
Keywords:
Tobacco consumption, semen parameters, reactive oxygen species, male infertility
Abstract
Background Tobacco consumption in any form is a well known health hazard and a major cause of mortality. This may affect male reproductive function and conveniently evaluated by semen analysis. Thus semen parameters of the subjects with habits of consumption compared within cases and control groups. Methods: Subjects referred for semen analysis & volunteers were studied. Detailed history of personal, occupational and tobacco consumption was obtained. Semen analysis performed as per the WHO guideline 2010, 5th edition. We included tobacco smokers, chewers and non-addicted subjects. Tobacco consumers further stratified according to type, amount and duration of consumption and various semen parameters from these groups compared by using ANOVA and unpaired-t test. Result: Out of 157 subjects, 25 as control, 32- tobacco smokers, 87- tobacco chewers, 13 with both habits, further stratified according to amount and duration of consumption. There is significant reduced semen parameters of tobacco consumers obtained in relation to its amount of consumption were- sperm concentration, motility and morphology, while not affected with duration of consumption. Oligozoospermia was higher in tobacco consumers. Conclusion: Results of study found that tobacco consumption in men is associated with reduced sperm quality (including count, motility & morphology). This concludes tobacco consumption is one of the risk factor in male infertility and subfertility.DOI:10.21276/APALM.1681References
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16. Arabi M, Moshtaghi H, Influence of cigarette smoking on spermatozoa via seminal plasma. Andrologia.2005; 37: 119-124.
17. Patel K. A Study on Effects of Cigarette Smoking on Various Semen Parameters; Int J Sci Reserch. 2013;2(11):423-425.
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20. Osser S, Backman-Ramirez A ,Liedholm P. Semen quality of smoking and non smoking men in infertile couple in a Swedish. Acta Obste-Gynecol Scand.1992;71:215-218.
21. Said TM, Ranga G, Agarwal A. Relationship between semen quality and tobacco chewing in men undergoing infertility evaluation. Fertil Steril. 2005;84:649-653.
22. Parmar N, Gohel V, Sarvaiya J, Patel N, Vala N. Effect of tobacco chewing on semen parameters; Int J of Med Sci and Public Health. 2016 ;5(06): 1139-1142.
23. Sunanda P, Panda B, Dash C, Ray PK, Padhy RN, Routray P. Prevalence of abnormal spermatozoa in tobacco chewing sub-fertile males; J Hum Reprod Sci. 2014; 7(2): 136–142.
24. Patel K. A Study on Effects of Cigarette Smoking on Various Semen Parameters; Int J Sci Reserch. 2013:2(11):423-425.
25. Dikshit RK, Buch JG, Mansuri SM. Effect of tobacco consumption on semen quality of a population of hypofertile males. Fertil Steril. 1987;48(2):334-336.
26. Riesenfeld A, Oliva H. Effects of nicotine on the fertility, cytology and life span of male rats. Acta Anat (Basel). 1988;131:171-176.
27. Ernster VL, Grady DG, Greene JC, Walsh M, Robertson P, Daniels TE,et al. Smokeless tobacco use and health effects among baseball players.JAMA.1990;264:218-224.
28. Dai JB, Wang ZX, Qiao ZD. The hazardous effects of tobacco smoking on male Fertility; Asian Journal of Andrology. 2015; 17: 954-960.
29. Mostafa T. Cigarette smoking and male infertility. J Adv Res. 2010;1:179-186.
30. Dechanet C, Anahory T, Mathieu Daude JC, Quantin X, Reyftmann L. Effects of cigarette smoking on reproduction. Hum Reprod Update. 2011; 17: 76-95.
2. Gupta B. Burden of smoked and smokeless tobacco consumption in India- results from the global adult tobacco survey India 2009-2010, Asian Pacific Journal of Cancer Prevention. 2013; 14(5):3323-3329.
3. Jhanjee S, Lal R, Mishra A, Yadav D. Tobacco use and dental myths in India: need for specific intervention, Gerodontology. 2015; 33(4):573-574
4. Thankappan KR, Thresia CU. Tobacco use and social status in Kerala, Indian Journal of Medical Research. 2007;126(4):300–308.
5. Gaisamudre KB, Waghmare AR, Naghate GR, Muneshwar J, “Study On Effect Of Cigarette Smoking On Sperm Count And Seminal Malondialdehyde Levels Of Infertile Men”; Int J Med Res Health Sci. 2013;2(3):451-457.
6. Kunzle R, Mueller MD, Hanggi W, Birkhauser MH, Drescher H, Bersinger NA. Semen quality of male smokers and nonsmokers in infertile couples, Fertil Steril 2003; 79:287–291.
7. Saleh RA, Agarwal A, Sharma RK, Nelson DR, Thomas AJ Jr. Effect of cigarette smoking on levels of seminal oxidative stress in infertile men: a prospective study, Fertil Steril 2002;78:491–499.
8. Patel K, Mehta N., Mehta AU. A study on effects of tobacco chewing on various semen parameters, Ind J App Basic Med Sci. 2015;17(24): 67-74.
9. Agarwal A, Said TM. Oxidative stress, DNA damage and apoptosis in male Infertility: a clinical approach, BJU Int. 2005; 95(4): 503-507
10. Armstrong J, Rajaskrishnan SM, Chamulitrat W, Gatti P, Hellstrom WJ, Sikka SC. Characterisation of reactive oxygen species induced effects on human spermatozoal movement and energy metabolism. Free radic.Biol.Med.1999; 26:869-880
11. Aydos K, Guven MC, Can B, Ergun A. Nicotine toxicity to the ultrastructure of the testis in rats. BJU Int. 2001; 88:622-626.
12. Chia SE, Ong CN, Tsakok FM. Effects of Cigarette Smoking On Human Semen Quality. Arch Androl. 2009; 33: 163-168.
13. Christen AG, Glover ED, Smokeless tobacco: Seduction of youth. World Smoking Health.1981; 6: 20–24.
14. Gaur DS, Talekar M, Pathak VP. Effect of cigarette smoking on semen quality of infertile men.Singapore Med J. 2007; 48: 119-123.
15. Holzki G, Gall H, Hermann J, Cigarette smoking and sperm quality, Andrologia.1991; 23:141-144.
16. Arabi M, Moshtaghi H, Influence of cigarette smoking on spermatozoa via seminal plasma. Andrologia.2005; 37: 119-124.
17. Patel K. A Study on Effects of Cigarette Smoking on Various Semen Parameters; Int J Sci Reserch. 2013;2(11):423-425.
18. Vine MF, Margolin BH, Morrison HI, Hulka BS. Cigarette smoking and sperm density: a meta-analysis. Fertil Steril. 1994;61:35-43.
19. Ozgur K, Isikoglu M, Seleker M, Donmez L. Semen quality of smoking and nonsmoking men in infertile couples in a Turkish population.Arch Gynecol Obstet. 2005;
271:109-112.
20. Osser S, Backman-Ramirez A ,Liedholm P. Semen quality of smoking and non smoking men in infertile couple in a Swedish. Acta Obste-Gynecol Scand.1992;71:215-218.
21. Said TM, Ranga G, Agarwal A. Relationship between semen quality and tobacco chewing in men undergoing infertility evaluation. Fertil Steril. 2005;84:649-653.
22. Parmar N, Gohel V, Sarvaiya J, Patel N, Vala N. Effect of tobacco chewing on semen parameters; Int J of Med Sci and Public Health. 2016 ;5(06): 1139-1142.
23. Sunanda P, Panda B, Dash C, Ray PK, Padhy RN, Routray P. Prevalence of abnormal spermatozoa in tobacco chewing sub-fertile males; J Hum Reprod Sci. 2014; 7(2): 136–142.
24. Patel K. A Study on Effects of Cigarette Smoking on Various Semen Parameters; Int J Sci Reserch. 2013:2(11):423-425.
25. Dikshit RK, Buch JG, Mansuri SM. Effect of tobacco consumption on semen quality of a population of hypofertile males. Fertil Steril. 1987;48(2):334-336.
26. Riesenfeld A, Oliva H. Effects of nicotine on the fertility, cytology and life span of male rats. Acta Anat (Basel). 1988;131:171-176.
27. Ernster VL, Grady DG, Greene JC, Walsh M, Robertson P, Daniels TE,et al. Smokeless tobacco use and health effects among baseball players.JAMA.1990;264:218-224.
28. Dai JB, Wang ZX, Qiao ZD. The hazardous effects of tobacco smoking on male Fertility; Asian Journal of Andrology. 2015; 17: 954-960.
29. Mostafa T. Cigarette smoking and male infertility. J Adv Res. 2010;1:179-186.
30. Dechanet C, Anahory T, Mathieu Daude JC, Quantin X, Reyftmann L. Effects of cigarette smoking on reproduction. Hum Reprod Update. 2011; 17: 76-95.
Published
2018-03-22
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