Hematological Profile of Sickle Cell Anemia Subjects in Central India: A Cross Sectional Analysis.
Keywords:
Hematological profile, Sickle Cell Anemia, steady state, Central India.
Abstract
Background: Sickle cell disease has high prevalence in Central India, ranging from 9.4-22.2% in different communities. Chronic normocytic normochromic hemolytic anemia is the typical finding in Sickle Cell Anemia (SCA). The hematological profile worsens during the complications. Thus knowledge of the average values of hematological parameters will be of utility to the clinicians.Methods: A cross sectional study was carried out in the Department of Pathology at a Medical Institute in Central India over the period of one and half years. Two ml of venous blood sample was collected in dipotassium ethylene diamine tetraacetic acid (K2 EDTA) bulb for complete blood count from SCA patients in steady state and analysed by automated hematology cell counter. All statistical analysis was done after recording the complete data of hematological parameters on Excel worksheet.Result: This study had lower average values of total hemoglobin, Red Blood Cell (RBC) count and hematocrit. Age wise increase in hemoglobin and hematocrit was noted till fourth decade. Higher values of Red Cell Distribution Width (RDW) and Reticulocyte count; and normal values of RBC indices, Platelet count, Total Leukocyte Count and Granulocyte % was seen.Conclusion: The average value of hematological parameters suggest moderate normocytic normochromic anemia in SCA patients in steady state. A larger scale work is recommended in this region for a baseline hematological profile for guiding the clinicians in management of these patientsDOI: 10.21276/APALM.1694References
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12. Castro O, Brambilla DJ, Thorington B, Reindorf CA, Scott RB, Gillette P, et al. The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell Disease. Blood 1994; 84(2): 643–649.
13. Hayes RJ, Beckford M, Grandison Y, Mason K, Serjeant BE, Serjeant GR. The haematology of steady state homozygous sickle cell disease: frequency distributions, variation with age and sex, longitudinal observations. Br J Haematol 1985; 59(2): 369–382.
14. Kulkarni RA, Gangane N, Sharma SM. Hematological Profile in Patients of Sickle Cell Anemia and Sickle Cell Trait in Relation to Blood Gas Analysis—Revisited. IJRTSAT, 2014; 10(1) 82–84.
15. Rao SS, Goyal JP, Raghunath SV, and Shah VB. Hematological profile of sickle cell disease from South Gujarat, India. Hematol Rep. 2012 May 10; 4(2): e8.
16. Davies S, Henthorn J, Brozovic M. Iron deficiency in sickle cell anaemia. J Clin Pathol.1983; 36: p.1012-1015.
17. Akinbami A, Dosunmu A, Adediran A, Oshinaike O, Adebola P, Arogundade O. Haematological values in homozygous sickle cell disease in steady state and haemoglobin phenotypes AA controls in Lagos, Nigeria. BMC Research Notes 2012, 5: 396.
18. West MS, Wethers D, Smith J, Steinberg M. Laboratory profile of sickle cell disease: a cross-sectional analysis. The Cooperative Study of Sickle Cell Disease. J Clin Epidemiol. 1992 Aug; 45(8): 893-909.
2. Quinn CT, Rogers ZR, Buchanan GR. Survival of children with sickle cell disease. Blood 2004; 103(11): 4023-27.
3. Shukla RM, Solanki BR. Sickle cell trait in Central India. Lancet 1985; 1: p.297-98.
4. Mohanty D, Pathare AV. Sickle cell Anemia – the Indian scenario. Indian J. Hematol Blood Transfus 1998; 16(1–1): 1–2.
5. Brown AK, Sleeper LA, Pegelow CH. The influence of infant and maternal sickle cell disease on birth outcome and neonatal course. Arch Pediatr Adolesc Med 1994; 148(11): 1156–1162.
6. O‟Brien RT, McIntosh S, Aspnes GT, Pearson HA. Prospective study of sickle cell anemia in infancy. J Pediatr 1976; 89(2): 205–210.
7. Schnog JB, Duits AJ, Muskiet FA, ten Cate H, Rojer RA, Brandjes DP. Sickle cell disease; a general overview. Neth J Med. 2004; 62(10): 364-74.
8. Kohchale SR, Raja IA. Hematological Profile of Sickle Cell Anemic Subjects from Gadchiroli District, Maharashtra. Int. J. of Life Sciences 2015; Special Issue A3: 153-156.
9. Swarnkar K, Kale A, Lakhkar B. Clinico-Epidemiological And Hematological Profile Of Sickle Cell Anemia With Special Reference To Penicillin Prophylaxis In A Rural Hospital Of Central India. The Internet Journal of Epidemiology 2010; 9(2).
10. Shrikhande AV, Dani AA, Tijare JR, Agrawal AK. Hematological profile of sickle cell disease in central India. Indian J Hematol Blood Transfus. 2007; 23(3-4): 92–98.
11. Gulbis B, Haberman D, Dufour D, Christophe C, Vermylen C, Kagambega F, et al. Hydroxyurea for sickle cell disease in children and for prevention of cerebrovascular events: the Belgian experience. Blood 2005; 105(7): 2685–2690.
12. Castro O, Brambilla DJ, Thorington B, Reindorf CA, Scott RB, Gillette P, et al. The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell Disease. Blood 1994; 84(2): 643–649.
13. Hayes RJ, Beckford M, Grandison Y, Mason K, Serjeant BE, Serjeant GR. The haematology of steady state homozygous sickle cell disease: frequency distributions, variation with age and sex, longitudinal observations. Br J Haematol 1985; 59(2): 369–382.
14. Kulkarni RA, Gangane N, Sharma SM. Hematological Profile in Patients of Sickle Cell Anemia and Sickle Cell Trait in Relation to Blood Gas Analysis—Revisited. IJRTSAT, 2014; 10(1) 82–84.
15. Rao SS, Goyal JP, Raghunath SV, and Shah VB. Hematological profile of sickle cell disease from South Gujarat, India. Hematol Rep. 2012 May 10; 4(2): e8.
16. Davies S, Henthorn J, Brozovic M. Iron deficiency in sickle cell anaemia. J Clin Pathol.1983; 36: p.1012-1015.
17. Akinbami A, Dosunmu A, Adediran A, Oshinaike O, Adebola P, Arogundade O. Haematological values in homozygous sickle cell disease in steady state and haemoglobin phenotypes AA controls in Lagos, Nigeria. BMC Research Notes 2012, 5: 396.
18. West MS, Wethers D, Smith J, Steinberg M. Laboratory profile of sickle cell disease: a cross-sectional analysis. The Cooperative Study of Sickle Cell Disease. J Clin Epidemiol. 1992 Aug; 45(8): 893-909.
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2018-01-28
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