Eccrine porocarcinoma of thigh : A rare adnexal tumour

  • Nikhil U Ningurkar Pathology department ACPM MC Dhule Maharashtra India
  • Nandkumar V Dravid Pathology department ACPM MC Dhule Maharashtra India
  • Dhiraj B Nikumbh Pathology department ACPM MC Dhule Maharashtra India
  • Arundhati S Gadre Pathology department ACPM MC Dhule Maharashtra India
  • Shivraj N Kanthikar Pathology department ACPM MC Dhule Maharashtra India
Keywords: Basal cell carcinoma, CK15, CK 7, eccrine porocarcinoma, EMA, immunohistochemistry.

Abstract

We report a rare case of eccrine porocarcinoma (EPC) in a 65 year old male patient. EPC arises from the intraepidermal portion of the eccrine sweat glands (acrosyringium). Previously the tumour was known as eccrine adenocarcinoma or malignant eccrine poroma with incidence predominantly in extreme of old age. The tumour arises most commonly on hands and feet. Rare sites like scalp, face, penis and abdomen are also reported in the literature. The distinction of porocarcinoma and basal cell carcinoma can be a diagnostic dilemma on a superficial biopsy. The histological features of high mitotic rate, tumour depth and lymphovascular invasion are bad prognostic markers. Immunohistochemistry for CK15, CK7, epithelial membrane antigen (EMA) and estrogen confirmed the diagnosis of EPC. This tumour is preferably treated with Moh’s surgery though few cases of metastasis are reported.DOI:10.21276/APALM.1713

Author Biography

Nikhil U Ningurkar, Pathology department ACPM MC Dhule Maharashtra India
Postgraduate student Pathology Department ACPM Medical College Dhule.

References

1) Mehregan AH, Hashimoto K, Rahbari H. Eccrine Adenocarcinoma A Clinicopathologic Study of 35 Cases. Arch Dermatol. 1983;119(2):104–114.

2) Robson A, Greene J, Ansari N, Kim B, Seed P T, McKee P H et al Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. Am J Surg Pathol. 2001;25:710–20.

3) Pinkus H, Mehregan AH. Epidermotropic eccrine carcinoma. Arch Dermatol. 1963;88:597-606.

4) Luz MA, Ogata DC, Motenergro MFG, Biasi LJ, Ribeiro LC Eccrine Porocarcinoma (Malignant Eccrine Poroma): A series of eight challenging cases. Clinics. 2010;65(7):739-42

5) Chang O, Elnawawi A, Rimpel B, Asarian A, Chaudhry N. Eccrine porocarcinoma of the lower extremity: A case report and review of literature. World Journal of Surgical Oncology. 2011;9:94.

6) Klenzner T, Arapakis I, Kayser G, Boedeker CC. Eccrine porocarcinoma of the ear mimicking basaloid squamous cell carcinoma. Otolaryngol Head Neck Surg. 2006;135:158-60.

7) Choi C-M, Cho H-R, Lew B-L, Sim W-Y. Eccrine Porocarcinoma Presenting with Unusual Clinical Manifestations: A Case Report and Review of the Literature. Annals of Dermatology. 2011;23(Suppl 1):S79-S83.

8) Shrestha P, Muramatsu Y, Kudeken W, Mori M, Takai Y, Ilg EC, et al. Localization of Ca(2+)-binding S100 proteins in epithelial tumours of the skin. Virchows Arch. 1998;432:53-59.

9) Mirza I, Kloss R, Sieber SC: Malignant eccrine spiradenoma. Arch Pathol Lab Med. 2002;126:591–594.

10) Ritter AM, Graham RS, Amaker B, Broaddus WC, Young HF. Intracranial extension of an eccrine porocarcinoma. Case report and review of the literature. J Neurosurg. 1999;90(1):138-40.

11) Grayson W, Loubser JS. Eccrine Porocarcinoma of the Penis. J Urol. 2003;169: 611-2.
Published
2018-02-27
Section
Case Report