Splenic lymphoma with villous lymphocytes; a case report with review of literature
Splenic lymphoma with villous lymphocytes (SLVL) is a rare low-grade B cell non-hodgkin's lymphoma with distinct clinical and morphologic features.
We report a case in a 55 year old man with the diagnosis of Chronic lymphocytic leukemia. On examination patient had no peripheral lymphadenopathy, but had splenomegaly of 2cm below costal margin. Laboratory investigations revealed WBC count 27.9x109/l with an absolute lymphocyte count of 22.3x109/l. Peripheral smear examination showed 80% lymphoid cells, 36% of which showed villous morphology, R-O nucleus, opened up chromatin and no nucleolus. Bone marrow aspirate and biopsy also showed involvement by these villous lymphocytes. These cells were negative for all cytochemical stains including tartrate-resistant acid phosphatase. On flow cytometric immuno-phenotyping these lymphoid cells were highly positive for CD19, CD20, FMC-7, moderately positive for CD10 and negative for CD5, CD23, CD25, CD103 and surface immunoglobulins (SIg) . Based on these findings a diagnosis of SLVL was suggested
Full Text:FULL TEXT PDF
Melo JV, Hegde U, Parreira A, Thompson I, Lampert IA, Catovsky D. Splenic B cell lymphoma with circulating villous lymphocytes: Differential diagnosios of B cell leukaemias with large spleens. J clin pathol 1987; 40: 642-51.
Mulligan S, Matutes E, Dearden C, Catovsky D. Splenic lymphoma with villous lymphocytes: natural history and response to therapy in 50 cases. Br J Haematol 1991;78:206-9.
Berger F, Felman P, Thieblemont C, Pradier T, Baseggio l, Bryon PA et al. Non-malt marginal zone B-cell lymphomas: a description of clinical presentation and outcome in 124 patients. Blood 2000;95:1950-6.
Swerdlow SH, Campo E, Harris NL, et al (Editors). WHO classification of tumours of hematopoietic and lymphoid tissues. Lyon, France: International Agency for Research on Cancer Press; 2008.
Bociek RG. Splenic marginal zone lymphoma: villous, not necessarily villainous. Oncology (Williston Park). 2012;26:208-10.
Armitage JO, Weisenburger DD. New approach to classifying non-hodgkin's lymphomas: clinical features of the major histologic subtypes. Non-hodgkin's lymphoma classification project. J clin oncol 1998;16:2780-95.
Gupta R, Naseem S, Sukumaran S, Kashyap R, Kaur S, Paul L. Splenic lymphoma with villous lymphocytes. Indian J Pathol Microbiol 2008;51: 113-5.
Matutes E, Morilla R, Owusu-ankomah K, Houlihan A, Catovsky D. The immunophenotype of splenic lymphoma with villous lymphocytes and its relevance to the differential diagnosis with other B cell disorders. Blood 1994;83:1558-62.
Bethel KJ, Sharpe RW. Pathology of hairy-cell leukaemia. Best Pract Res Clin Haematol. 2003;16:15-31.
Cawley JC. The pathophysiology of the hairy cell. Hematol Oncol Clin North Am 2006;20:1011-21.
Thieblemont C, Felman P, Callet-Bauchu E, Traverse-Glehen A, Salles G, Berger F et al. Splenic marginal zone lymphoma: a distinct clinical and pathological entity. Lancet oncol 2003;4:95-103.
- There are currently no refbacks.
Annals of Pathology and Laboratory Medicine (APALM) is licensed under a Creative Commons Attribution 4.0 International License. Based on a work at APALM