Eccrine Angiokeratomatous Hamartoma: Report of a Case with Brief Review

  • Vijayashree Raghavan Chettinad Hospitals and Research Institute
  • Devi Subbarayan Chettinad Hospitals and Research Institute
  • Ramesh K Rao Chettinad Hospitals and Research Institute
Keywords: Eccrine Angiokeratomatous Hamartoma, Eccrine Angiomatous Hamartoma, Solitary Angiokeratoma, CD34, SMA, Cytokeratin


Eccrine angiokeratomatous hamartoma is a newly recognised vascular lesion of the skin, with the first case being reported only in 2006.  It has a distinctive histology with features derived from two well established vascular lesions affecting the skin: solitary angiokeratoma and eccrine angiomatous hamartoma. A 26 year old woman presented with a long standing painless warty lesion on her right ankle. Histological examination of the excised lesion showed a combination of two vascular lesions: superficial angiokeratoma and a deeper eccrine angiomatous hamartoma. Such a histological picture is consistent with the diagnosis of recently described eccrine angiokeratomatous hamartoma. Our case represents only second such case to be reported. Immunohistochemical analysis with CD34, smooth muscle actin and cytokeratin was done.   

Author Biographies

Vijayashree Raghavan, Chettinad Hospitals and Research Institute
Associate Professor, Department of Pathology
Devi Subbarayan, Chettinad Hospitals and Research Institute
Assistant Professor, Department of Pathology
Ramesh K Rao, Chettinad Hospitals and Research Institute
Professor and HOD, Department of Pathology


1. Kanitakis J, Ly A, Claudy A. Eccrine angiokeratomatous hamartoma: A new variant of eccrine hamartoma with angiokeratoma. J Am Acad Dermatol. 2006; 55: S104-6.

2. Imperial R, Helwig EB. Angiokeratoma. A clinicopathological study. Arch Dermatol. 1967; 95:166-75

3. Hyman AB, Harris H, Brownstein MH. Eccrine angiomatous hamartoma. N Y State J Med. 1968; 68:2803-6.

4. Nehls V, Drenckhahn D. Heterogeneity of Microvascular Pericytes for Smooth Muscle Type Alpha-Actin. J Cell Biol. 1991; 113:147-54.

5. Martinelli P, Tschen J. Eccrine angiomatous hamartoma: a case report and review of the literature. Cutis. 2003; 71:449-55.

6. Pelle M, Pride H, Tyler W. Eccrine angiomatous hamartoma. J Am Acad Dermatol. 2002; 47:429-35.

7. Kar S, Krishnan A, Gangane N. Eccrine Angiomatous Hamartoma: A Rare Skin Lesion with Diverse Histological Features. Indian J Dermatol. 2012; 57:225-7.

8. Smith V, Montesinos E, Revert A, Ramon D, Molina I, Jorda E. Eccrine angiomatous hamartoma: report of three patients. Pediatr Dermatol. 1996; 13:139-42.

9. Yi-Ting Lin, Chien-Ming Chen, Chih-Hsun Yang, Yea-Huey Chuang. Eccrine Angiomatous Hamartoma: A Retrospective Study of
15 Cases. Chang Gung Med J 2012; 35:167-77.

10. Shin J, Jang YH, Kim S, YC K. Eccrine Angiomatous Hamartoma: A Review of Ten Cases. Ann Dermatol. 2013; 25:208-21.

11. Natarajan K, Rai R, Sundararajan V, Venkatchala S. Eccrine angiomatous hamartoma in an adult. Indian J Dermatol Venereol Lepr. 2009; 75:193-4.

12. Ghosh SK, Bandyopadhyay D, Chatterjee G. Multiple Eccrine Angiomatous Hamartoma in a Young Boy: A Case Report. Turk Acad Dermatol 2008; 2 (2). Retrieved from

13. Naik V, Arsenovic N, Reed M. Eccrine angiomatous hamartoma: A rare multifocal variant with features suggesting trauma. Dermatology Online Journal. 2009; 15(9). Retrieved from:

14. Challa VR, Jona J. Eccrine angiomatous hamartoma: A rare skin lesion with diverse histological features. Dermatologica. 1977; 155:206-9.

15. Kandalgaonkar S1, Tupsakhare S, Patil A, Agrawal G, Gabhane M, Sonune S. Solitary Angiokeratoma of Oral Mucosa: A Rare Presentation. Case Rep Dent. 2013; 2013:812323.
Case Report